What is Hapacol 650 and how does it work?

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1. Mechanism of action of Hapacol 650

The ingredient Paracetamol in Hapacol 650 is effective in reducing pain and fever. When the drug enters the body, it will act on the thermoregulatory center in the hypothalamus to create a cooling process, and also increase thermogenesis due to vasodilation along with increased peripheral blood flow. That will lower the body temperature of the person with a fever. However, the drug Hapacol 650 also quite rarely has the effect of lowering body temperature in the normal state. In addition, Paracetamol also helps reduce pain by raising each person's pain threshold.
When using antipyretic drug Hapacol 650 at therapeutic dose, the drug has antipyretic and analgesic effect equivalent to Aspirin, but Paracetamol has little impact on cardiovascular and respiratory systems. At the same time, it does not change the acid base balance in the body. In addition, Hapacol 650 does not cause irritation, scratch or stomach bleeding.
Drug Hapacol 650 put into the body has the ability to absorb quickly and almost completely absorbed through the gastrointestinal tract. The half-life of the drug is about 1.25 to 3 hours and the drug is metabolised in the liver, followed by renal elimination.

2. Indications and contraindications for the use of Hapacol 650

What is Hapacol 650? Hapacol 650 is effective in the treatment of pain symptoms in cases such as headache, migraine, toothache, pain due to flu, sore throat, pain due to arthritis, pain after injection, sore throat,. .. In addition, the drug also helps reduce fever for patients who have a cold or are related to an increase in body temperature that causes fever.
However, the drug is also contraindicated in cases of hypersensitivity to one of the components of the drug. Or patients with glucose-6 phosphate dehydrogenase deficiency should not use Hapacol 650.

3. Dosage and how to use Hapacol 650

Hapacol 650 is used for adults and children over 12 years old with a dose of 1 tablet once and can be taken 3 to 4 times a day. The interval between two doses is usually 4 to 6 hours. Do not take more than 6 pills of Hapacol 650 a day.
For patients with severe renal failure with creatinine clearance less than 10ml/min, the interval between oral doses must be at least 8 hours.
Using Hapacol 650 should pay attention to the maximum dose in 24 hours should not exceed 4 grams and the interval between two doses. The drug should not be used when new symptoms appear or the fever is higher than 39.5 degrees and the fever lasts more than 3 days or the fever recurs. Do not use the drug in case of severe pain and duration of more than 5 days.
The dosage of the drug above is for reference only. Therefore, if you use the drug to improve the health of your eyes, you need to learn carefully and consult a doctor.
If you forget to take your medicine, use it as soon as you remember. However, if the missed dose is close to the next dose, you should skip the missed dose and take the next dose. You should note that you should not double the dose, because this can cause bad symptoms affecting health.
In case of drug overdose, the drug will not help improve the symptoms of the disease immediately. Instead, it can cause poisoning or serious side effects. If you suspect you have overdosed on sodium hyaluronate, call your doctor or seek medical attention immediately.
How to handle drug overdose is as follows:
Overdose with Paracetamol can be caused by taking a single dose or taking repeated large doses of about 7.5 to 10 grams a day, or it can be due to the use of Paracetamol. continuous long-term drug use. Symptoms may include vomiting, abdominal pain, along with cyanosis of the skin, mucous membranes and nails. It can even cause liver necrosis due to doses with acute toxic effects and death. When intoxication with Paracetamol is severe, it is necessary to receive active supportive treatment. Take the patient for a gastric lavage first and it is best to do this within 4 hours of taking the medication. Detoxification therapy in this case often uses compounds such as Sulfhydryl. N-Acetylcysteine ​​is effective when taken orally or intravenously. Your doctor must prescribe this medicine immediately if it has not been 36 hours since you took Paracetamol. Treatment with N-acetylcysteine ​​is more effective when indicated for less than 10 hours after taking Hapacol 650. In addition, Methionine, activated charcoal or salt bleach can be used to support overdose treatment. Use Hapacol 650.
Overdose of caffeine may be rare, but symptoms can often cause restlessness, agitation, and even delirium.

4. Unwanted side effects when using Hapacol 650

Hapacol 650 contains Paracetamol which can cause unwanted side effects in some cases such as allergies, skin rash, vomiting/nausea. A few rare cases can cause pancytopenia, leukopenia, anemia. The drug can even cause liver failure due to hepatocellular destruction when used in high doses and for a long time.
Hapacol 650 contains caffeine, so when using high doses of caffeine, it can cause high blood pressure, drowsiness during the day. Moreover, this component of the drug also causes other side effects such as nausea, vomiting, insomnia, headaches, tremors, nervousness, anxiety... When experiencing signs of side effects, you should stop Use the medicine and tell your doctor right away.

5. Some notes when using Hapacol 650

For people with phenylketonuria and those who need to limit the amount of phenylalanine put into the body, Hapacol 650 should not be used with Paracetamol or Aspartame-containing foods. People with hypersensitivity such as asthma should avoid using Hapacol 650 or foods containing sulfites. For people with pre-existing anemia or impaired liver and kidney function, the use of Hapacol 650 should be limited. Those who drink a lot of alcohol, which can increase liver toxicity, should also limit the use of Hapacol 650. and even alcohol. When using drugs with high caffeine content can cause high blood pressure, so Hapacol 650 should be used with caution in patients with high blood pressure Hapacol 650 contains Paracetamol which may require a doctor. warn of signs of serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell's syndrome, or acute generalized exanthematous pustulosis. Drug interactions Hapacol 650: Taking drugs containing Paracetamol for a long time may slightly increase the anticoagulant effect of Coumarin and Indandion derivatives in the body. Therefore, attention should be paid to the potential for severe hypothermia in individuals using concomitant phenothiazines and hypothermia therapy. Hapacol 650 in combination with anticonvulsants, or isoniazid may increase hepatotoxicity. In addition, patients should avoid taking the drug with drugs or oral odof containing caffeine. Hapacol 650 medicine contains the active ingredient Paracetamol 650mg and excipients. The drug is prepared in the form of tablets and is indicated for use in cases of pain relief such as headache, migraine, sore throat, menstrual pain,... To ensure the effective treatment and avoid the side effects. Unwanted side effects, patients need to take prescription drugs or consult a doctor or pharmacist.
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