This is an automatically translated article.
Combizar is a combination antihypertensive drug with the main ingredients Losartan and Hydrochlorothiazide. Please refer to the use and contraindications of the drug in the article below.
Thuốc Combizar là thuốc điều trị tăng huyết áp đường uống dạng phối hợp
1. What is Combizar?
Combizar is a combination antihypertensive drug with the main ingredients Losartan potassium 50mg and Hydrochlorothiazide 12.5mg. In particular, Losartan belongs to the class of angiotensin II receptor blockers that work by dilating blood vessels so that blood can flow more easily. In combination with hydrochlorothiazide is a thiazide diuretic, which increases water excretion by inhibiting the reabsorption of sodium and chloride ions in the distal tubule.2. Indications of the drug Combizar
Combizar is indicated in the treatment of hypertension in patients suitable for combination therapy.
3. Dosage of combizar
Recommended dosage: Initial and maintenance dose in adults: 1 tablet once daily.
For unresponsive patients, adjust to maximum dose: 2 tablets daily.
4. Combizar side effects
The side effects of the drug are mostly mild, transient and do not require stopping treatment.
Some unwanted effects may be encountered when taking the drug such as:
Whole body: Abdominal pain, weakness, edema, headache Cardiovascular: Heart palpitations Digestion: Diarrhea, nausea Skeletal muscle: Back pain God Nervous system: Dizziness Respiratory system: Dry mouth, upper respiratory infection, bronchitis, pharyngitis, sinusitis Skin: Rash.
5. Contraindications of the drug combizar
Combizar is contraindicated in the following cases:
Hypersensitivity to any component of the drug Hypersensitivity to sulfonamide derivatives Pregnant women Patients with anuria
6. Be careful when using combizar
Do not use the drug in people who may have intravascular dehydration (eg, patients treated with high-dose diuretics). The combination form of Losartan - Hydrochlorothiazide should not be used in patients with severe renal impairment (creatinine clearance < 30 ml/min) or in patients with hepatic impairment. Consider low dose for patients with a history of renal failure. liver failure. Losartan may increase blood urea and serum creatinine in patients with bilateral renal artery stenosis or arterial stenosis of individuals with only one kidney. These changes are reversible upon discontinuation of treatment. Ability to drive and use machines: There are no studies on the effect of the drug on the ability to drive and use machines. However, dizziness or drowsiness may be experienced at the beginning of treatment or when the dose is increased. Pregnancy: When used in pregnant women during the second and third trimesters of pregnancy, the drug can cause harm, even death to the fetus. Discontinue use of losartan as soon as pregnancy is discovered. Lactation: Due to the potential for adverse effects in the nursing infant, the benefits and risks of discontinuing breastfeeding should be weighed against discontinuation of the drug.
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