What is Cefditoren?

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1. Uses of the drug Cefditoren

Cefditoren antibiotic is indicated in the treatment of infections caused by susceptible gram-negative and gram-positive bacteria (including respiratory tract infections, skin infections, subcutaneous tissue infections):
Treatment of pharyngitis and tonsillitis caused by susceptible strains of Streptococcus pyogenes; Treatment of acute exacerbations of mild and moderate chronic bronchitis caused by strains of Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae and Moraxella catarrhalis; Treatment of community-acquired pneumonia caused by strains of Haemophilus parainfluenzae, Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis; Treatment of infections of the skin and subcutaneous tissue caused by strains of Streptococcus pyogenes, Staphylococcus aureus. Cefditoren is contraindicated in the following cases:
Hypersensitivity to Cefditoren, other Cephalosporins or excipients of the drug; Carnitin deficiency, congenital metabolic disorder leading to clinical carnitin deficiency; Hypersensitivity to milk proteins; Children under 12 years old.

2. How to take and dose of Cefditoren

How to use: Take the drug with a meal to increase the absorption of the drug into the blood.
Dosage for adults:
Treatment of pharyngitis and tonsillitis: 200mg/time x 2 times/day for 10 days; Treatment of acute exacerbations of chronic bronchitis: 400mg/time x 2 times/day for 10 days; Treatment of community-acquired pneumonia: 400mg/time x 2 times/day for 14 days; Treatment of infections of the skin and subcutaneous tissue: Use a dose of 200mg/time x 2 times/day for 10 days. Dosage for children:
Children over 12 years old take a dose of 200-400mg/time x 2 times/day.
Dosage for other subjects:
Patients with hepatic impairment: No dose adjustment is required for patients with mild and moderate hepatic impairment. There is no information on the use of Cefditoren in patients with severe hepatic impairment; Elderly: There are no special recommendations on the dose of Cefditoren if the patient has normal renal function; Patients with renal failure: Depending on creatinine clearance: Specifically: ClCr 50 - 80ml/min: No dose adjustment is required; ClCr 30 - 49ml/min: Use up to 200mg/time x 2 times/day; ClCr <30ml/min: Dose 200mg/time/day; Patients with end-stage renal failure: The appropriate dose has not been determined. Overdose: There is no information on overdosage of Cefditoren in humans. However, side effects of overdose may include: Nausea, vomiting, epigastric pain, convulsions, diarrhea,... Patients may be on hemodialysis to remove Cefditoren from the body if impaired kidney function. Overdose should be treated symptomatically, and necessary supportive measures should be taken.
Missed dose: If you miss a dose of Cefditoren, take it as soon as you remember. If it is almost time for the next dose, the patient should skip the missed dose and take the next dose as scheduled.

3. Side effects of the drug Cefditoren

When using Cefditoren, patients may experience some unwanted side effects:
Common: Diarrhea; Uncommon: Nausea, headache, hyperglycemia, anorexia, abdominal pain, vomiting, hematuria, decreased hematocrit, leukopenia,...; Rare: Acute renal failure, arthralgia, allergies, bronchial asthma, hypocalcemia, hypernatremia, increased clotting time, fungal infections, chromosomal erythema, hyperglycemia, leukopenia, inflammation interstitial lung disease, hyponatremia, hyperkalemia, pseudomembranous colitis, thrombocytopenic purpura, Stevens-Johnson syndrome, toxic skin necrosis.

4. Precautions while using Cefditoren

When using Cefditoren, patients need to be careful:
Treatment with the antibiotic Cefditoren can upset the balance of microflora in the colon, causing Clostridium difficile to overgrow, causing diarrhea from mild to critical. . Toxins produced by Clostridium difficile are associated with increased morbidity and mortality due to antibiotics, requiring colectomy. Therefore, it is necessary to monitor this manifestation throughout the course of treatment; Monitor and detect hypersensitivity when using Cefditoren. Should be used with caution in people with a history of hypersensitivity to penicillin, especially anaphylaxis, urticaria; Cefditoren should be used with caution in patients with a history of convulsions. If kidney failure is present, the risk of convulsions is increased; Cefditoren should be used with caution in cases of liver failure, renal failure, the dose should be adjusted accordingly; For patients with carnitin deficiency, do not use Cefditoren for a long time because Cefditoren increases carnitin excretion; Cefditoren may prolong the prothrombin time, so caution should be exercised in its use in patients with bleeding disorders; Cefditoren tablets contain the excipient sodium caseinate, which may cause hypersensitivity reactions in patients with a history of hypersensitivity to milk proteins; Cefditoren should be used with caution in pregnant and lactating women.

5. Cefditoren drug interactions

Some drug interactions with Cefditoren to note include:
Probenecid increases the concentration of Cefditoren in the blood plasma, thereby increasing the effect or toxicity of Cefditoren; Antacids, H2-receptor antagonists, proton pump inhibitors reduce the absorption of Cefditoren, thereby reducing the effect or toxicity of Cefditoren. Therefore, avoid concomitant use of Cefditoren with these drugs; May cause some erroneous results when testing; Food increases the absorption of Cefditoren. Meals high in fat will maximize the bioavailability of the drug. Cefditoren, which works by stopping the growth of bacteria, is used in the treatment of many different bacterial infections. When taking the drug, the patient should absolutely follow the doctor's instructions, do not abuse, change the dose, arbitrarily combine with other drugs, ... to avoid dangerous side effects.
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