This is an automatically translated article.
Agilosart-H 50/12.5 mg includes the ingredients Losartan and Hydrochlorothiazide. This drug is effective in the treatment of high blood pressure. Agilosart-H 50 is made in the form of film-coated tablets, the package includes a box of 3 blisters x 10 film-coated tablets.
1. What is Agilosart 50?
Dosage forms of Agilosart:
Agilosart 12.5, each tablet contains Losartan potassium 12.5mg. The drug is in the form of round, yellow film-coated tablets, smooth on both sides, 6.0 mm in diameter. Agilosart 25 or Agilosart 50, each tablet contains Losartan potassium 25mg or 50mg. Agilosart 100, each tablet contains Losartan potassium 100mg. The drug is in the form of oval tablets, pink film-coated, one side is smooth, one side has 1 horizontal line, size 6.5 mm x 12.5 mm. The drug is effective in the treatment of mild to moderate hypertension, used alone or in combination with other antihypertensive drugs.
2. Undesirable effects of the drug Agilosart 50
Common undesirable effects when using Agilosart 50, ADR > 1/100
On cardiovascular system such as hypotension, chest pain. About the central nervous system including sleep disturbances, insomnia, dizziness, fatigue. On endocrine-metabolic such as hyperkalemia, hypoglycemia. About the digestive system such as digestive disorders, diarrhea, indigestion. On hematology, such as a slight decrease in hemoglobin and hematocrit. Neuromusculoskeletal including back pain, leg pain, muscle fatigue. About the kidneys such as hypouricemia (when using high doses of drugs), urinary tract infections. Respiratory system such as cough (less often with ACE inhibitors), nasal congestion or sinusitis. Uncommon side effects when using Agilosart 50, ADR < 1/100
About the cardiovascular system such as orthostatic hypotension, chest pain, second-degree A-V block, palpitations, sinus bradycardia, heart rate rapid, facial swelling, red face. Central nervous system such as anxiety disorder, ataxia, confusion, depression, migraine, headache, sleep disturbance, fever, dizziness. Dermatologically such as hair loss, dermatitis, dry skin, erythema, photosensitivity, rash, urticaria, bruises on the skin. On endocrine-metabolic such as gout. About the digestive system such as anorexia, constipation, flatulence, vomiting, loss of taste, gastritis. Regarding the genitourinary and urinary systems such as impotence, sexual dysfunction, polyuria, nocturia. Liver: Slight increase in liver function indices and slight increase in bilirubin. Neuromusculoskeletal such as paresthesia, tremor, bone pain, muscle weakness, joint edema, muscle fatigue, fibromyalgia. Eyes such as blurred vision, conjunctivitis, decreased vision, burning and pain in the eyes. Ears appear tinnitus. Kidneys such as urinary tract infection, slight increase in creatinine or urea. Respiratory function: Shortness of breath, bronchitis, nosebleeds, rhinitis, airway congestion, throat discomfort. Other undesirable effects may be encountered such as sweating.
Caution: Special monitoring and/or dose reduction is required in:
People who are dehydrated, treated with diuretics and who have other factors predisposing to hypotension. People with bilateral or unilateral renal artery stenosis, who have only one kidney, are also at high risk of adverse effects, namely increased creatinine and blood urea nitrogen. Patients with liver failure must take lower therapeutic doses.
3. Drug interactions of Agilosart 50
Other Antihypertensives: The antihypertensive effect of Agilosart 50 may be enhanced when used with other antihypertensive agents. Drugs that affect potassium: The potassium-depleting effect of Hydrochlorothiazide is minimized by the potassium-sparing effect of losartan. However, this effect of hydrochlorothiazide on serum potassium is likely to occur with the concomitant use of other drugs that cause potassium loss and hypokalemia. Conversely, when used with potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium or other drugs that cause hyperkalemia, an increase in serum potassium may occur. Lithium: Active ingredient Losartan increases serum lithium concentrations, in addition, renal clearance of Lithium is reduced by thiazides. Losartan does not affect the pharmacokinetics of oral or intravenous digoxin. Cimetidine, when used in combination with Agilosart 50, increased the area under the curve (AUC) of losartan by approximately 18%, but did not affect the pharmacokinetics of the active metabolite of losartan. Phenobarbital co-administered with Agilosart 50 reduced the AUC of losartan and its active metabolite by approximately 20%. Rifampicin, Aminoglutethimide, Carbamazepine, Nafcillin, Nevirapine, Phenytoin, decreased plasma concentrations of losartan and its metabolites when used concomitantly. Agilosart 50 increases the effect of drugs: Amifostin, antihypertensive drugs, carvedilol, hypoglycemic agents, lithium, potassium-sparing diuretics, rituximab. Non-steroidal anti-inflammatory drugs (NSAIDs), especially COX-2, used in combination with Agilosart 50 can cause kidney failure, so doctors often prescribe monitoring of kidney function. Alcohol, barbiturates or narcotic hypnotics: Increased risk of orthostatic hypotension. Antidiabetic drugs (oral drugs and insulin): Dosage adjustment is required due to hyperglycemia. Corticosteroids, ACTH: Increases loss of electrolytes, especially potassium in the blood. Hypertensive amines eg Norepinephrine: May decrease response to hypertensive amines. Muscle relaxants such as Tubocurarine: May increase response to muscle relaxants. Non-Steroidal Anti-Inflammatory Drugs: May reduce the diuretic, sodium and hypotensive effects of thiazides in some users. Quinidine: Easily causes torsades de pointes causing ventricular fibrillation. Reduces the effect of drugs with anticoagulant effect, drugs to treat gout. Increases the effect of anesthetic drugs, glycosides, vitamin D. Cholestyramine resin or colestipol: There is a risk of binding thiazide diuretics, reducing the absorption of these drugs from the gastrointestinal tract. Increased digitalis toxicity and increased risk of arrhythmias with drugs that prolong the QT interval such as astemizol, terfenadine, halofantrin, pimozide and sotalol. Allopurinol, Tetracycline: Increased toxicity when used in combination with thiazides.
4. Some notes when using Agilosart 50
Before treating diseases with drugs, you should carefully read the instructions for use and refer to the information below.
4.1. Contraindications of the drug Agilosart 50 Agilosart-H is contraindicated in the following cases:
Hypersensitivity to the component Losartan, to thiazides and sulphonamide derivatives or to any of the components of the drug. Pregnant women or mothers who are breastfeeding. Hypokalemia, hypercalcemia. People with severe liver failure. Patients with renal failure have serum creatinine > 250 mmol/liter or blood potassium 25 mmol/liter or creatinine clearance < 30 mmol/liter/min. People with anuria. 4.2. Other precautions when using Agilosart 50 Ability to drive and use machines: As with other antihypertensive drugs, caution should be taken if Agilosart 50 is used while driving or operating machinery due to The drug may cause headache, dizziness, and fatigue, especially at the beginning of treatment or when the dose is increased. Pregnancy: Agilosart 50 is contraindicated in pregnant women. Administration of drugs that act directly on the renin-angiotensin system during the second and third trimesters of pregnancy may result in oligohydramnios, hypotension, anuria, oliguria, craniofacial deformity, and death. infant mortality. Although the use of the drug only in the first trimester of pregnancy has not been shown to be associated with risks to the fetus, but when you find out that you are pregnant, you need to stop taking the drug as soon as possible. Lactation: Currently, there are no studies to prove that losartan is excreted in human milk, but thiazides do pass into breast milk. Because of adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, depending on the importance of the use of the drug to the mother. The drug Agilosart-H 50/12.5 mg includes the ingredients Losartan and Hydrochlorothiazide. This drug is effective in the treatment of high blood pressure. To ensure the effectiveness of treatment, avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
