What group of antibiotics does Biseptol 480mg belong to?

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Biseptol 480mg is a synthetic antibiotic, consisting of 2 antibiotics combined in a certain ratio. This antibiotic has the effect of inhibiting the growth of bacteria, indicated when there is an infection, especially most often used in gastrointestinal infections.

1. What group of antibiotics does Biseptol 480mg belong to?

Biseptol is an antibiotic consisting of 2 main ingredients, sulfamethoxazole and trimethoprim, with a ratio of sulfamethoxazole: trimethoprim of 5:1 and some other excipients. In which:
Sulfamethoxazol is an antibiotic of the sulphonamide group, which inhibits the synthesis of folic acid by bacteria. PABA (para aminobenzoic acid) is an essential material for bacteria to synthesize folic acid to grow, but because the sulphonamides have a chemical structure similar to that of PABA, the sulfamid competes with PABA thereby preventing the bacterial synthesis of folic acid. Not only that, sulfamid also inhibits dihydrofolate synthetase, an enzyme involved in folic acid synthesis. Therefore, the general effect of the sulphonamide group is bacteriostatic. As a broad-spectrum antibiotic, it can be used in many cases, but now, due to many drug resistance, it is rarely used alone, but often used in combination. Trimethoprim is an antibiotic derivative of pyrimidine, inhibiting bacterial dihydrofolate reductase enzyme, thus inhibiting bacterial DNA synthesis, thereby having bacteriostatic effect. Commonly used in the treatment of gastrointestinal infections, urinary tract infections, exacerbations of chronic bronchitis... Trimethoprim can be used alone in the treatment of disease or in combination with sulfamethoxazole.
When such a combination of trimethoprim and sulfamethoxazole results in a stronger antibacterial effect. Not only that, the combination of these two drugs also combats the growth of bacteria that cause resistance and works even when bacteria are resistant to each ingredient in the drug.

2. What are the effects of biseptol 480mg?

Biseptol is a broad-spectrum antibiotic used to treat infections caused by gram (-), gram (+) bacteria, but mainly intestinal bacteria.
Indications for treatment of biseptol:
Infections caused by bacteria sensitive to sulfamethoxazole and trimethoprim antibiotics. Treatment of urinary tract infections. Gastrointestinal infections caused by e.coli, bacillus dysentery. Patients with Pneumocystis carinii pneumonia and prevention of Pneumocystis carinii infection in individuals with congenital or acquired immunodeficiency. Acute exacerbation of chronic bronchitis, cheek sinusitis in adults. Upper respiratory tract infections such as nasopharyngitis, sinusitis, tonsillitis and patients with otitis media. Biseptol is also used to treat osteomyelitis when there is pus in the bones. Contraindications:
The body has excessive allergic reactions to any of the components of the drug. People with severe liver and kidney failure. If you are pregnant or breastfeeding, use may lead to a deficiency of folic acid, which is necessary for the normal development of the fetus or newborn. Serious diseases of the hematopoietic system, megaloblastic anemia caused by folic acid deficiency. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency

3. Undesirable effects

When using biseptol may occur some undesirable effects such as:
Common: About 1% of patients develop fever, nausea and vomiting, diarrhea, glossitis, itching and rash on the skin. Uncommon: From 0.1% to 1%: Decreased white blood cell count, neutropenia, purpura, urticaria. Rare: Less than 0.1%: Stevens-Johnson syndrome, Lyell syndrome (toxic epidermal necrolysis), neutropenia, thrombocytopenia, hemolytic anemia, aseptic meningitis, jaundice, liver failure, anaphylaxis, hyperkalemia, hypoglycemia, hallucinations, kidney failure, interstitial nephritis, kidney stones, tinnitus... Handling some cases causing digestive disorders due to use biseptol. Usually caused by folic acid deficiency, treated by folic acid supplementation from 5-10mg/day.

4. Notes when using biseptol . antibiotics

Biseptol should not be used concurrently with some other drugs that can cause drug interactions such as: Rifampicin antibiotics, Cyclosporine drugs, warfarin, Biseptol drugs should not be used concurrently with thiazide diuretics because it will increase the risk of hypokalemia and bleeding, digoxin, tricyclic antidepressants. Biseptol should be used with caution in patients with allergic conditions. Biseptol should not be used while using alcohol, because it increases the risk of toxic hepatitis. During the course of taking the drug, it is necessary to limit vigorous exercise such as weight training, racing... In case of overdose, it can cause acute poisoning with manifestations such as nausea, vomiting, abdominal pain, headache and confusion. mental disorder. The drug should be stopped immediately and consulted a qualified doctor for treatment. Biseptol should not be used arbitrarily, but should only be used for treatment when prescribed by a doctor. Biseptol is a group of broad-spectrum antibiotics, widely indicated in the treatment of bacterial infections. However, when using it, be careful of the unwanted effects of the drug for timely handling.

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Reference source: healthvietnam.vn