What does Vigentin 500mg do?

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Vigentin is a combination antibiotic with 2 main ingredients, amoxicillin and clavulanic acid, with many dosage forms such as tablets, powder for suspension. So what does vigentin do and how does it work?

1. What is vigentin?

Vigentin is an antibiotic combination with the main ingredients amoxicillin and clavulanic acid with different strengths such as vigentin 875mg/125mg, 500mg/125mg, 500mg/62.5mg, 250mg/62.5mg. The drug is used for the short-term treatment of bacterial infections: Upper respiratory tract infections, lower respiratory tract infections, severe urinary-genital tract infections caused by strains, skin and soft tissue infections, bone and joint infections, dental infections, abortion-associated infections.
Vigentin can be prepared as a powder for oral suspension, film-coated tablets or dispersible tablets.

2. Uses of the drug vigentin

Vigentin is used for short-term treatment of the following infections:
Upper respiratory tract infections: Tonsillitis, sinusitis, otitis media that have been treated with common antibiotics but have not improved. . Lower respiratory tract infections by beta-lactamase-producing strains of H.influenzae and Branhamella catarrhalis: Acute and chronic bronchitis, pneumonia - bronchiolitis. Severe infections of the urinary tract - genitourinary by strains: E.coli, Klebsiella and Enterobacter producing beta - lactamase: Cystitis, urethritis, pyelonephritis. Skin and soft tissue infections: boils, abscesses, wound infections. Bone and joint infections: Osteomyelitis. Dental infections: Alveolar abscess. Other infections: Infections caused by abortion.

3. Mechanism of action of the drug vigentin

Amoxicillin is a beta-lactam antibiotic with a broad bactericidal spectrum against many bacteria by inhibiting bacterial cell wall synthesis. However, amoxicillin is very susceptible to destruction by beta-lactamase enzymes, so it is not effective against strains of bacteria that produce these enzymes (many strains of Enterobacteriaceae and Haemophilus influenzae).
Clavulanic acid is due to the fermentation of Streptomyces clavuligerus, which has a beta-lactam structure similar to that of penicillin, capable of inhibiting beta-lactamase enzymes produced by most Gram-negative bacteria and Staphylococcus. In particular, it has a strong inhibitory effect on plasmid-transmitted beta-lactamases that cause resistance to penicillins and cephalosporins. Pseudomonas aeruginosa, Proteus morganii and rettgeri, some strains of Enterobacter and Providentia are resistant, and even methicillin-resistant staphylococcus is resistant to this drug. Clavulanic acid itself has a very weak antibacterial effect. Clavulanic acid prevents amoxicillin from being destroyed by beta-lactamases and effectively extends the antibacterial spectrum of amoxicillin to many bacteria normally resistant to amoxicillin, other penicillins and cephalosporins.

4. Contraindications of Vigentin

Vigentin is contraindicated in the following cases:
Hypersensitivity to any component of the drug Allergy to penicillins Infectious mononucleosis or lymphocytic leukemia Cross-allergy to cephalosporins

5. How to take Vigentin

How to use Vigentin:
With powder form for oral suspension: Mix the powder in the pill pack with just enough warm water to drink. For tablets: take the tablet whole with a glass of water. Dosage of Vigentin
Adult dose: 500mg/time, 3 times/day.
Children from 40kg and over: take according to the adult dose.
Children under 40kg:
With tablets: the usual dose is 20mg amoxicillin/kg/day, divided into several times 8 hours apart. For the treatment of otitis media, sinusitis, lower respiratory tract infections and severe infections, the usual dose is 40 mg amoxicillin/kg/day in divided doses every 8 hours for 5 days. Do not use 250mg film-coated tablets for children under 40kg. With powder for oral suspension: the usual dose is 80mg amoxicillin/kg/body weight/day, divided into 3 doses for 24 hours.

6. Undesirable effects when taking Vigentin drugs

Vigentin may have side effects such as:
Common side effects: Diarrhea, rash, itching. Uncommon side effects: Erythema, rash, eosinophilia, nausea, vomiting, hepatitis, cholestatic jaundice, increased transaminases (may be severe and persist for several months). Rare side effects: anaphylaxis, Quincke's edema, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, pseudomembranous colitis, hemolytic anemia, interstitial nephritis. Vigentin is a combination antibiotic with 2 main ingredients, amoxicillin and clavulanic acid, with many dosage forms such as tablets, powder for suspension. The drug is indicated for the treatment of infectious diseases. To ensure the effectiveness of treatment, patients should carefully read the instructions and consult a doctor, pharmacist before use.
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