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Anti-inflammatory Corticosteroid is one of the drugs widely used in clinical practice, of which the most popular is the active ingredient Methylprednisolone - the main active ingredient of Gomes 16mg. So what are the effects of Gomes and what should be noted during use?
1. What is Gomes?
Gomes medicine prepared in tablet form is a product of Dat Vi Phu Pharmaceutical Joint Stock Company. Gomes medicine has the main ingredient is Methylprednisolone (an active corticosteroid) content of 16mg. In terms of pharmacodynamics, the active ingredient Methylprednisolone in the drug Gomes 16mg is essentially a Glucocorticoid and a 6-alpha-methyl derivative of Prednisolone. Therefore, the drug Gomes brings anti-inflammatory, anti-allergic and immunosuppressive effects. Methylprednisolone is the result of the prednisolone methylation reaction, the effects related to salt metabolism have been excluded, thereby limiting the side effects of salt (sodium) retention and edema. The effectiveness of the anti-inflammatory drug Gomes is increased by 20% compared to that of Prednisolone and at a dose of 4mg Methylprednisolone is equivalent to 20mg of Hydrocortisone.
Pharmacokinetic characteristics:
Bioavailability of Gomes is approximately 80%. Maximum plasma concentrations are reached 1-2 hours after dosing. At the same time, the pituitary inhibitory effect lasts about 15 days and is classified as short-acting; Gomes is metabolized in the liver, similar to hydrocortisone. The metabolites are then excreted in the urine; The half-life of Gomes is approximately 3 hours.
2. What are the effects of Gomes?
Gomes is indicated for use in the following cases:
Non-specific therapy requiring the anti-inflammatory and immunosuppressive effects of Glucocorticoids in rheumatoid arthritis, systemic lupus erythematosus, some forms of inflammation vessels such as temporal arteritis and nodular periarteritis; Sarcoid disease, bronchial asthma; Chronic ulcerative colitis; Hemolytic anemia; Severe allergies, including anaphylaxis; Certain cancers such as acute leukemia, lymphoma, breast cancer and prostate cancer; Primary nephrotic syndrome. Besides, some cases should not use anti-inflammatory drug Gomes (Contraindications):
People who are allergic or sensitive to Methylprednisolone or other ingredients of Gomes drug; In the process of vaccination with live attenuated vaccine ; Severe systemic infections (unless being treated with specific antibacterial therapy).
3. Dosage of the drug Gomes 16mg
How to use: Patients need to take Gomes tablets whole with a full glass of water, can be taken with or without food.
Dosage of Gomes drug depends on each medical condition and the patient's condition and adjusts accordingly, it is best to use the minimum dose that still achieves the desired therapeutic effect. The specific dosage of Gomes 16mg is as follows:
Treatment of rheumatoid arthritis: Very severe: 12-16mg; Severity: 8-12mg; Moderate level: 4-8mg; Children: 4-8mg. Asthma treatment: 64-100mg; Systemic dermatitis, malignant rheumatic fever: 48mg; Treatment of eye diseases, allergies: 12-40mg; Treatment of systemic lupus erythematosus: 20-100mg; Treatment of blood diseases, leukemia, malignant lymphoma: 16-100mg; Treatment of ulcerative colitis: 16 - 60mg.
4. Side effects of Gomes 16mg
During treatment with Gomes medicine, patients can completely experience unwanted effects (ADRs).
Some common undesirable effects of the drug Gomes:
Nervous system disorders such as insomnia, mental excitability; Increased appetite, indigestion; Hairy hair; Increased blood sugar ; Athritis; Cataracts, glaucoma; Nosebleed; Some rare side effects when using anti-inflammatory drugs Gomes:
Dizziness, appearance of convulsions; Mental disorders; Pseudotumor brain; Headache, mood swings; Delirium, hallucinations or feelings of euphoria; Edema; Hypertension; Acne breakouts, skin atrophy, bruising, hyperpigmentation; Muscle weakness, osteoporosis, increased risk of fractures; Hypersensitivity reactions. Patients should carefully read the instructions for use of Gomes before taking. If you need more information or have any questions, consult your doctor. Note that Gomes should only be used as prescribed by a doctor. In case of experiencing side effects of Gomes, the patient should stop taking the drug, then promptly notify the doctor or go directly to the nearest medical facility for timely treatment.
5. Some cautions when using the drug Gomes
Patients who are being treated with systemic corticosteroids at doses much higher than physiological doses (for Gomes, more than 6mg per day) for more than 3 weeks should not suddenly stop taking the drug; Corticosteroids such as Gomes 16 can obscure signs of infection and impair the body's natural immune response to an infectious agent; Some pathogens such as tuberculosis bacteria, malaria parasites can have a long incubation period for many years. Treatment with anti-inflammatory drugs Gomes can trigger these agents to reactivate, thereby causing dangerous diseases. Cases of confirmed tuberculosis requiring the use of anti-tuberculosis drugs during prolonged corticosteroid use; Particular caution and regular monitoring of systemic corticosteroids (such as Gomes) are required in the following cases: Osteoporosis (note menopausal women); Hypertension; History of or current mental illness; Diabetes mellitus; History of tuberculosis; Increased intraocular pressure; Liver failure, cirrhosis; CKD; Epileptic; Stomach ulcers; Congenital factors of thrombophlebitis; Ulcerative colitis, diverticulitis; Severe weakness. Corticosteroids such as Gomes 16mg can slow down the growth of children at the stage of physical development. Therefore, children taking Gomes should follow the doctor's instructions; There are no reports on the effects of Gomes 16mg on the ability to drive and use machines; Women who are pregnant or breast-feeding can use Gomes, but should be very cautious when using high doses for a long time.
6. Drug interactions of Gomes 16mg
The active ingredient Methylprednisolone in Gomes induces cytochrome P450 enzyme and is a substrate of P450 3A enzyme, thus can affect the metabolism of Cyclosporin, Erythromycin, Phenobarbital, Phenytoin, Carbamazepine, Ketoconazole, Rifampicin; Hypokalemic diuretics may decrease the effectiveness of Gomes. Gomes anti-inflammatory drugs cause hyperglycaemia, thus requiring adjustment of insulin and antidiabetic agents accordingly. Gomes medicine has the main ingredient is Methylprednisolone (an active corticosteroid) content of 16mg. The drug is indicated for many diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take drugs according to prescription or consult a doctor, professional pharmacist.
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