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Budecort drug is used in anti-inflammatory treatment effectively and safely because it has been proven. Let's find out what Budecort drug works in the following article.
1. What is aerosol Budecort?
Budecort is a corticosteroid that reduces inflammation in the body, is anti-allergic and immunosuppressive. It is used to treat symptoms of shortness of breath and wheezing caused by chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, laryngeal leukemia, and asthma. manage .
The main ingredient of the drug is Budesonide (corticosteroid) BP 0.5mg and other excipients just enough for 2ml. Budesonide is administered to the respiratory tract and is minimally absorbed throughout the body, with rare systemic effects in patients with mild to moderate asthma.
2. What does Budecort do?
Budecort has inhibitory effect on many types of cells such as macrophages, neutrophils, eosinophils,... and some chemical mediators such as cytokines, histamine,... involved in the reaction. inflammation, is effective in the treatment of bronchial asthma, patients with laryngeal diphtheria, bronchial asthma when it is necessary to replace reducing oral steroids or some other unadapted steroids.
Budecort drug with the main ingredient is Budesonide, which has the effect of reducing the inflammatory response, increasing the concentration of some membrane phospholipids, causing inhibition of prostaglandin synthesis. Budecort also increases the concentration of lipocortin, reduces the phospholipid substrates of phospholipase A2. In addition, corticosteroids decrease capillary permeability by inhibiting the activity of kinins and bacterial endotoxins, thereby reducing the amount of histamine secreted by basophils.
3. How to use Budecort
3.1. Dosage and Administration of Budecort The dose administered to each patient varies depending on the nebulizer device used. Nebulization time and dose delivery depend on flow rate, nebulizer chamber volume, and fill volume. An air flow rate should be used of 6 - 8 liters per minute through the unit.
Suitable filling volume for most nebulizers is 2 - 4 ml. The dosage of Budesonide Nebuliser Suspension should be adjusted to individual needs. For patients with asthma, the dose should be reduced to the minimum necessary. In the case of children under 12 years of age with severe and limited asthma, the highest dose - equivalent to 2 mg / day.
In adults, the potential for systemic delivery of budesonide following administration of Budesonide Nebuliser Suspension via a nebulizer is approximately 15% of the standard dose and 40% to 70% of the patient infusion dose. A small amount of medicine from the vibrating gas can be swallowed into the body. Peak plasma concentrations, occurring about 10 to 30 minutes after the start of the nebulizer, are comparable to 4 nmol/l after a 2 mg dose.
In the treatment of bronchial asthma, for people with severe asthma, while reducing or stopping oral glucocorticosteroids, when starting treatment, the recommended dose of Budesonide Nebuliser Suspension is:
Adults (including the elderly): The recommended dose is from 1 - 2 mg x 2 times / day. However, the dosage may vary depending on the severity of the disease. Children: For children 12 years and older, the dose is the same as adults. For children from 3 months to 12 years old, 2 times a day, 0.5 - 1 mg each time. Maintenance dose should be individualized and is the lowest dose that helps asymptomatic patients:
People 12 years of age and older: 2 times a day, 0.5 - 1 mg each time. For children from 3 months to 12 years old: 0.25 - 0.5 mg x 2 times / day. In patients maintained on oral glucocorticosteroids:
To maintain control of asthma, nebulizer suspension Budesonide may allow replacement or significant reduction in oral glucocorticosteroids. When initiating infusion from oral steroids to budesonide nebulizer suspension, the patient should be in a relatively stable phase. A high dose of budesonide aerosol suspension is then administered in combination with the previously used oral steroid dose for approximately 10 days. Thereafter, the dose of oral steroid should be gradually reduced (eg, 2.5 milligrams of prednisolone or equivalent monthly) to the lowest possible level. In many cases, it is possible to completely replace oral steroids with budesonide nebulizer suspension. Dosage division and miscibility:
Budesonide Nebuliser Suspension can be reconstituted with 0.9% saline and with solutions for aerosolization of Terbutaline, Salbutamol, Fenoterol, Acetylcysteine, Sodium cromoglycate or Ipratropium bromide. Additives should be used within 30 minutes. When an increased therapeutic effect is desired, especially in patients with low airway mucus secretion, the dose of Budesonide Nebuliser Suspension should be increased, rather than in combination with oral corticosteroids, because of the low risk of systemic effects. than.
The usual dose for infants and children with lung cancer is 2 mg of budesonide aerosol. 2mg as a single dose or split into 2 doses of 1mg, 30 minutes apart, may be repeated every 12 hours for up to 36 hours or until clinical improvement.
3.2. Instructions for use of Budecort Nebulizer Tube:
Must be detached from the strip, gently shaken and opened by twisting the wing cap. Squeeze gently into the aerosol cup. The empty tube should be discarded and the top of the aerosol cup should be replaced. Nebulizer:
Budesonide nebulizer suspension must be used with a nebulizer supplied with a mouthpiece or mask. The nebulizer must be connected to an air compressor with a suitable flow rate (6-8 l/min) and a filling volume of 2-4 ml. There can be differences in performance (dosage delivery) between nebulizers, even those of the same make and model. 3.3. Precautions when using Budecort Nebulizer When using Budecort nebulizer it is important to note the following:
It is important that patients read carefully the instructions for use in the information leaflet that is packaged with each nebulizer. To minimize the risk of oropharyngeal candidiasis, patients should rinse their mouths with water after inhalation. To avoid irritation, it is recommended to wash your face thoroughly after using the nebulizer with the mask. The nebulizer should be cleaned after each use. Wash the nebulizer container and mouthpiece or mask according to the manufacturer's instructions. Do not use Budecort for people who are hypersensitive to any of its ingredients. Studies have not been able to reveal an increased risk of adverse events for the fetus and neonate from inhaled budesonide use during pregnancy. But inhaled budesonide therapy should be reviewed regularly and maintained at the smallest dose to be effective. Budesonide is excreted in human milk. However, at therapeutic doses of Budesonide, there was no effect on the nursing infant. Budesonide can be used during lactation. Inhaled budesonide has no or negligible influence on the ability to drive and use machines. 3.4. Undesirable effects when using Budecort aerosol The following side effects may occur:
The following definitions apply to the incidence of undesirable effects: Frequency is defined as: Very common (≥1 / 10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from available data).
3.5. Budecort Overdose Symptoms: Acute overdose with Budesonide usually does not constitute a clinical problem. The only harmful effect after a large dose of the spray in a short time is suppression of cortical function.
If it is a chronic problem of using very high doses, effects such as cortical atrophy in addition to adrenocortical suppression may occur.
Treatment of Acute Overdose: No acute measures are required. Budesonide treatment should be continued at the lowest effective maintenance dose possible, and adrenocortical function should recover spontaneously within 1-2 days.
Chronic Overdosage: Patients should be treated for steroid dependence and switched to an appropriate maintenance dose with systemic steroids, eg Prednisolone. Once the patient's condition is stabilized, the patient should continue to receive budesonide inhalation at the recommended dose.
Budecort is used to treat symptoms of shortness of breath, wheezing caused by chronic obstructive pulmonary disease. The drug can cause side effects, so patients need to use it under the guidance of the treating doctor.
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