This is an automatically translated article.
Vastec 20mg drug also known as Vastarel is often used to treat unstable angina or in cases where the patient is intolerant to other therapies.1. What disease does Vastarel treat?
The drug is indicated as an adjunct to or adjunct to the patient's existing therapies for the treatment of stable but inadequately controlled angina or in cases where the patient is unresponsive to other methods of treatment.
2. Pharmacodynamics of Vasstarel
Trimetazidine is an active ingredient contained in Vastarel with the function of inhibiting the oxidation of fatty acids by inhibiting the activity of the long-chain 3-ketoacyl-CoA thiolase enzyme produced in ischemic cells. The enhancement of glucose oxidation will help optimize cellular energy and rational metabolism during periods of anemia. Trimetazidine acts as a metabolite in patients with ischemic heart disease, thereby helping to maintain an adequate source of phosphate energy in muscle cells. The advantage of trimetazidine is that it has an anti-ischemic effect but does not affect hemodynamics.
Vastarel (vastec 20mg) chứa hoạt chất chính là Trimetazidine
3. Pharmacokinetics of Vasstarel
Trimetazidine when entering the body will be absorbed very quickly and plasma concentrations will peak within 2 hours after oral administration. Approximately 24 to 36 hours after taking a dose, equilibrium in the blood is reached and remains stable during treatment. The half-life of the drug is about 6 hours and is eliminated in the urine.
4. How to take Vastec 20mg
Vastec 20mg drug is used with oral and at the same time with meals. Dosage of the drug is 20mg / time, 3 times a day. Some special subjects need to be careful when using the drug such as:
Moderate renal failure: For patients with creatinine clearance [30-60 ml/min, it is recommended to use a dose of 1 20mg tablet, taken orally. 2 times/day in the morning and evening, at the same time with meals; Elderly: Elderly people whose kidney function declines with age may be more sensitive to trimetazidine than the general population. The same dose can be used for this age group as for patients with moderate renal impairment described above; Children: There are no recommendations or evaluations regarding the safety and effectiveness of trimetazidine in patients under 18 years of age. Note that the above dosage is for reference only. Depending on the specific condition of the patient, the doctor will give the appropriate dose. Therefore, it is necessary to consult a medical professional to get the best treatment effect.
5. Some notes when using Vastarel
Vastec 20mg drug has some of the following contraindications:
Patients with a history of hypersensitivity to any ingredient of the drug. Patients with Parkinson's disease or symptoms such as tremors, restless legs syndrome and other movement disorders. Patients with severe renal failure. Precautions for use:
Patients with Parkinson's disease when using Trimetazidine active ingredient may worsen symptoms of the disease such as tremor, difficulty in movement, increased muscle tone. Therefore, when using it, it should be monitored and checked regularly. When a patient has symptoms of Parkinson's disease such as restless legs syndrome, unsteady gait, tremor, it is necessary to see a specialist for examination and appropriate indications. Or while using, if the patient has the above symptoms, it is necessary to immediately stop using it. Most of these cases recovered after about 4 months of discontinuation of the drug. Particular caution should be exercised when prescribing to highly susceptible subjects such as patients with moderate renal impairment or patients over 75 years of age. The drug may affect the ability to drive or use machines due to symptoms of drowsiness, dizziness. The drug should not be used by women who are pregnant or breast-feeding because there are no adequate studies on this subject. Above is information about the drug Vastec 20mg and notes when using. To ensure safety for health and maximize the effectiveness of treatment, the use of drugs must follow the instructions of a qualified doctor.
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