What diseases does Rotalzon 50mg treat?

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Rotalzon contains the main active ingredient, Losartan - belongs to the group of angiotensin II receptor antagonists, indicated in the treatment of hypertension. The dose of treatment varies from person to person depending on the condition and the progression of the disease.

1. What disease does Rotalzon treat?


Rotalzon 50mg drug is indicated for use in the following cases:
Treatment of hypertension: The drug is used alone or in combination with other antihypertensive drugs, including diuretics. Hypertension in patients with left ventricular hypertrophy: Rotalzon is indicated to reduce the risk of stroke in hypertensive patients with left ventricular hypertrophy. Renal Disease in Diabetic Patients: Rotalzon is indicated for the treatment of diabetic nephropathy in the presence of elevated serum creatinine and proteinuria (albuminuria/creatinine ratio > 300 mg/g) in patients with diabetes mellitus. have a history of high blood pressure. In these patients, Rotalzon reduced the incidence of kidney disease as measured by a doubling of serum creatinine or end-stage renal disease (requiring dialysis or requiring a kidney transplant).

2. How to take Rotalzon 50mg


How to use: Rotalzon 50mg can be taken with or without food and in combination with other antihypertensive drugs.
Dosage:
Hypertension: The starting and maintenance dose is 50mg/time/day for most patients. The maximum antihypertensive effect is achieved after starting treatment 3 - 6 weeks. Some patients may see an even more pronounced effect with increased doses up to 100 mg once daily; In volume-depleted patients (such as those treated with high-dose diuretics) the recommended starting dose is 25 mg once daily; No dose adjustment is necessary for elderly patients or patients with renal impairment, including those on dialysis. However, in patients with a history of hepatic impairment, a dose reduction is required. Reduction of cardiovascular disease risk and cardiovascular mortality in hypertensive patients with left ventricular hypertrophy, starting dose of 50 mg once daily; A low dose hydrochlorothiazide should be added and/or the dose should be increased to 100 mg once daily based on blood pressure response. For the protection of renal function in type 2 diabetic patients with proteinuria, the initial dose is 50 mg once daily. This dose may be increased to 100 mg once daily based on blood pressure response; Rotalzon can be used with a number of other antihypertensive drugs such as: diuretics, calcium channel blockers, alpha or beta blockers and some centrally acting drugs; The drug can be used with insulin and other common hypoglycemic agents such as Sulfonylurea, Glitazone, Glucosidase inhibitors. Pediatric Use: The antihypertensive effect of Losartan has been established in hypertensive children > 1 month to 16 years of age. Losartan pharmacokinetics were studied in 50 pediatric patients, aged > 1 month to less than 16 years, at doses of 0.54 to 0.77 mg/kg body weight once daily. Active metabolites are also formed in all age groups. The pharmacokinetics of losartan and its active metabolite are similar and consistent with data from studies in adults; For patients who are able to swallow tablets, the dose is 25 mg once daily with a body weight > 20 to < 50 kg. The dose may be increased to a maximum of 50 mg once daily; For patients over 50 kg, the starting dose is 50 mg once daily. The maximum increase dose is 100 mg, 1 time / day; Use in the elderly: In clinical studies, there were no age-related differences in safety and efficacy. Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease. To get the right dose, you need to consult your doctor or healthcare professional.

3. Contraindications of Rotalzon 50mg


Rotalzon 50 is contraindicated in cases where the patient is sensitive to any of its ingredients.
4. Side effects of rotalzon 50mg When using Rotalzon 50, you may experience undesirable effects of the drug such as:
Losartan was well tolerated in controlled clinical studies in high patients. hypertension with left ventricular hypertrophy. Drug-related side effects are mostly: Dizziness, dizziness, weakness or fatigue. The drug is also well tolerated in patients with type 2 diabetes mellitus with proteinuria. Common side effects are weakness, dizziness, hypotension, and hyperkalemia. Hypersensitivity reactions: Edema of the larynx, glottis causing airway obstruction and/or facial edema, swelling of the lips, larynx and/or swelling of the tongue. These signs were rare in patients treated with losartan, some of whom experienced edema during treatment with other ACE inhibitors. Dermatitis including Henoch-Schoenlein purpura is rare. Digestive system: Hepatitis (rare), poor liver function. Hematology: Anemia, thrombocytopenia (rare). Musculoskeletal: Myositis, arthritis. Nervous system/psychiatric: Migraine. Respiratory: Cough. Skin: Urticaria, itching. When experiencing side effects of the drug, it is necessary to stop using it and notify the doctor or go to the nearest medical facility for timely treatment.

5. Be careful when using Rotalzon 50mg


Use caution when using Rotalzon 50mg in the following cases:
Hypersensitivity: Angioedema. Low blood pressure, fluid and electrolyte imbalance: In patients with hypovolaemia, such as those on diuretics, in patients with signs of hypotension. It is necessary to adjust the dose or reduce the initial dose in these cases. Impaired Liver Function: Based on pharmacological data showing significantly increased plasma concentrations of losartan in patients with cirrhosis, dose reduction should be considered in patients with preexisting conditions. history of poor liver function. Impaired Renal Function: As a result of inhibition of the renin-angiotensin system, altered renal function, including impairment of renal function has also been reported in susceptible individuals. This change in function is reversible upon discontinuation of therapy. Other drugs affecting the renin-angiotensin system may increase blood urea and serum creatinine in patients with unilateral or bilateral renal artery stenosis. The same effect applies to Rotalzon. These changes are reversible upon discontinuation of treatment. Ability to drive and use machines: Do not drive or operate machinery while taking this medicine because the drug can cause dizziness, lightheadedness, dizziness. Pregnancy: The drug acts directly on the renin-angiotensin system, so when prescribed for pregnant women, it can cause death or disease for the fetus and newborn. If pregnancy is detected, losartan should be discontinued. Although there is no experience with the use of the drug in pregnant women, animal studies have shown that the drug can cause death or harm to the fetus and newborn, the mechanism of action is believed to be due to the effects of the drug. mediated through the action of the renin-angiotensin system. Lactation: There is no evidence that the drug is excreted in milk. Due to the possibility of many drugs being excreted in milk and the potential for adverse reactions in the nursing infant, discontinue use or discontinue nursing. The benefits, harms, and risks to the mother should be weighed. Rotalzon 50mg is one of the drugs indicated for the treatment of hypertension. However, patients need to take the drug exactly as prescribed by the doctor to increase the effectiveness of treatment and ensure safety for health.

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