What disease does Omeprazole 20mg treat?

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Omeprazole 20mg drug is in the form of hard capsules, the main ingredient is omeprazole 20mg, used to treat and prevent recurrence of gastric and duodenal ulcers, gastroesophageal reflux disease or Zollinger-Ellison syndrome, ...

1. What disease does Omeprazole 20mg treat?

What is Omeprazol TVP 20mg? The active ingredient in this medicine is omeprazole 20mg. Omeprazole has the ability to inhibit gastric acid secretion. Taking a single dose of 20mg Omeprazole daily will suppress gastric acid secretion. In patients with peptic ulcers, an 80% reduction in gastric acid can be maintained for 24 hours. In addition, Omeprazole also has the ability to inhibit Helicobacter Pylori (HP) in patients with duodenal ulcer or reflux esophagitis caused by HP. Combining Omeprazole with some antibacterial drugs can kill HP, heal ulcers, and help remission.
Indications for the use of Omeprazol in the following cases:
In adults: Treatment of duodenal ulcer, gastric ulcer; prevent gastric and duodenal ulcers; treatment of gastroesophageal reflux - oesophagitis; combined with antibiotics to treat gastric and duodenal ulcers caused by HP; treatment of Zollinger-Ellison syndrome; In children over 1 year old and over 10kg: Treatment of esophagitis, heartburn, acid reflux in gastroesophageal disease; In children 4 years of age and older: In combination with appropriate antibiotics for the treatment of gastric and duodenal ulcers caused by HP.

2. Instructions for using Omeprazole

2.1 How to take Omeprazol 20mg Oral medication, should be taken in the morning, take the whole tablet with 1/2 cup of water. The patient should not chew or crush the tablet. For patients with dysphagia or children, the tablet should be taken orally with liquid food.
Patient can open the capsule, dissolve the powder with 1/2 cup of water or mix the powder in a mildly acidic juice or non-carbonated drink, stir well and drink immediately. Always stir just before drinking, rinse with 1/2 cup of water.
2.2 Dosage of Omeprazole 20mg Dosage in adults:
Treatment of duodenal ulcer: Use dose 20mg/time/day for 2 weeks. If the patient has not completely recovered, treatment can be continued for another 2 weeks; Treatment of stomach ulcers: 20mg/time/day for 4 weeks. If the patient has not completely recovered, treatment can be continued for another 4 weeks; Prevention of recurrence of gastric and duodenal ulcers: Use dose 20mg/time/day. The dose may be increased to 40mg once a day if treatment fails; Kill HP in peptic ulcer disease: Omeprazol 20mg + clarithromycin 500mg + amoxicillin 1000mg: 2 times/day for 1 week; Omeprazole 20mg + clarithromycin 250mg (or 500mg) + metronidazol 400mg (or 500mg or tinidazol 500mg): 3 times a day for 1 week; Omeprazole 40mg/time/day + [amoxicillin 500mg + metronidazol 400mg (or 500mg or tinidazol 500mg): 3 times/day for 1 week; Treatment of NSAID-associated gastric and duodenal ulcers: 20mg/time/day for 4 weeks. If the patient has not completely recovered, treatment can be continued for another 4 weeks; Prevention of NSAID-associated gastric and duodenal ulcers: Dose 20mg/time/day; Treatment of esophagitis caused by gastroesophageal reflux - oesophagitis: Use a dose of 20mg / time / day for 4 weeks. If the patient is not completely cured, the treatment period can be extended by 4 weeks. In patients with severe esophagitis, a dose of 40 mg once daily for 8 weeks can be used; Treatment of Zollinger-Ellison syndrome: Initial dose is 60mg/time/day. The usual effective dose is 20 - 120 mg/day. If the dose is over 80mg, it should be divided into 2 times/day. Dosage and duration of drug use depend on the clinical requirements of the doctor; Patients with hepatic impairment: May need dose reduction, daily dose is 10-20mg; Patients with renal impairment and the elderly: No dose adjustment is required.
Dosage in children:
Children over 1 year old, body weight 10-20 kg: Use dose 10mg/time/day.
Children over 2 years old, body weight over 20k: Use dose 20mg/time/day.
With the above dose, the indications for treatment are as follows:
Treatment of esophageal reflux: Use the drug for 4 - 8 weeks. The dose can be increased to 20mg/day if needed; Symptomatic treatment of heartburn, acid reflux in gastro-oesophageal disease: Use the drug for 4 - 8 weeks. The dose may be increased to 20 mg/day if needed. If the disease cannot be controlled, the disease should be re-evaluated. Children over 4 years old: Treatment of gastric and duodenal ulcers caused by HP with the following recommended doses:
Children 15 - 30 kg: Omeprazol 10mg + clarithromycin 7.5mg/kg + amoxicillin 25mg/kg: 2 times/day in 1 week; Children 31 - 40 kg: Omeprazol 20mg + clarithromycin 7.5mg/kg + amoxicillin 750mg: 2 times/day for 1 week; Children over 40kg: Omeprazol 10mg + clarithromycin 500mg + amoxicillin 100mg: 2 times/day for 1 week; Note: Omeprazole dosage above is for reference only. The doctor will base on the condition and progress of the disease to determine the appropriate dose for the patient.
Overdose: When drug overdose, patients are treated symptomatically, there is no specific treatment.
Missed dose: If you forget to take a dose of Omeprazole, you should take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose as scheduled.

3. Omeprazole 20mg side effects

When using Omeprazol, patients may experience some unwanted effects:
Common: Headache, dizziness, drowsiness, diarrhea, nausea, vomiting, constipation, abdominal pain, bloating ,...; Uncommon: Insomnia, fatigue, sensory disturbances, skin pruritus, urticaria, rash, transient transaminase elevation,...; Rare: Sweating, peripheral edema, angioedema, fever, anaphylaxis, leukopenia, thrombocytopenia, thrombocytopenia, agranulocytosis, autoimmune hemolytic anemia, reversible confusion , depression, agitation, hallucinations, hearing disorders, gynecomastia in men, gastritis, dry mouth, candidiasis, hepatitis, encephalopathy - liver in patients with liver failure, bronchospasm, muscle pain, joint pain, interstitial nephritis,... When experiencing the above side effects, patients should stop taking Omeprazole and notify their doctor immediately.

4. Notes when using Omeprazole 20mg

Contraindications to the use of Omeprazol in the following cases:
Hypersensitivity to the active ingredients in the drug; Omeprazole and nelfinavir should not be used concurrently. Caution when using Omeprazole:
Omeprazole can mask symptoms, delay diagnosis in people with malignant lesions in the stomach; In patients with renal impairment and the elderly, no dose modification is required; In patients with hepatic impairment, the elimination of the drug is slow, the dose may need to be reduced; Use of Omeprazole may increase the risk of gastrointestinal infections; Prolonged use of Omeprazole may increase the risk of infections and fractures, especially in the elderly; Using Omeprazole for a long time reduces blood magnesium, so it is necessary to monitor the concentration of magnesium in the blood plasma when using the drug; Concomitant use of atazanavir with proton pump inhibitors will reduce plasma concentrations of atazanavir, so it is necessary to increase the dose of atazanavir to 400 mg and ritonavir 100 mg, not to exceed 20 mg of Omeprazol; Omeprazole may reduce the absorption of vitamin B12 with long-term treatment; Omeprazole is an inhibitor of CYP2C19. When starting and ending treatment with Omeprazole, the possibility of drug-metabolizing CYP2C19 interactions should be considered; Proton pump inhibitors are associated with subacute lupus erythematosus. If lesions occur, especially in places exposed to light, accompanied by symptoms of joint pain, the patient should notify the doctor, stop taking Omeprazol; Omeprazole can cause dizziness, drowsiness, so it should be used with caution in drivers, operating machinery; With caution, consult your doctor when using Omeprazole in pregnant and lactating women.

5. Drug interactions Omeprazole 20mg

Some drug interactions of Omeprazole 20mg:
The drug has no clinical effect when taken with food, alcohol, caffeine, lidocaine, amoxicillin, bacampicillin, quinidine or theophylline. The drug is not affected by the concomitant use of metoclopramide; Omeprazole may lead to increased blood levels of ciclosporin; Omeprazole can increase the effect of antibiotics when killing HP; Omeprazole inhibits the metabolism of drugs metabolised by the liver cytochrome P450 enzyme system, which may increase blood levels of phenytoin, diazepam and warfarin. At a dose of 40 mg/day, Omeprazole can inhibit the metabolism of phenytoin, increasing the concentration of phenytoin in the blood. As for the dose of Omeprazole 20mg/day, the interaction is weaker; Omeprazole inhibits the metabolism of warfarin but has little effect on bleeding time; Omeprazole increases the anticoagulant effect of dicoumarol; Omeprazole reduces the metabolism of nifedipine by at least 20%, possibly increasing the effect of nifedipine; Clarithromycin inhibits the metabolism of the drug Omeprazole, causing the concentration of Omeprazole to double; Omeprazole reduces stomach acid, causing increased or decreased absorption of drugs depending on gastric pH; Concomitant use of Omeprazol with atazanavir reduces plasma concentrations of atazanavir; Omeprazole drug interaction with clopidogrel reduces exposure to active metabolites; Co-administration of omeprazole with tacrolimus may increase tacrolimus serum concentrations; Omeprazole may reduce the absorption of vitamin B12 with long-term treatment; Concomitant use of Omeprazole with erlotinib, posaconazole, ketoconazole and itraconazole will reduce the effect of these drugs; Co-administration of methotrexate with proton pump inhibitors increases methotrexate concentrations in some patients. When using Omeprazole, patients need to follow all instructions of their doctor to ensure effective treatment and reduce the risk of unpredictable side effects. At the same time, patients should inform their doctor about the medications they are taking to eliminate the risk of drug interactions.
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