What are the uses of Telfast 60mg?

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Telfast 60mg is a medicine for seasonal allergic rhinitis or for cases of chronic idiopathic urticaria. Medicines can bring side effects and risks, so patients need to be careful to use the drug in the correct dose prescribed by the doctor.

1. What is Telfast 60mg?

Telfast 60mg is a medicine used mainly for the treatment of seasonal allergic rhinitis and uncomplicated skin signs of chronic idiopathic urticaria in adults and children over 12 years of age. . Telfast 60mg is produced in the form of film-coated tablets, oblong, pale pink, 2 convex sides, one side engraved with the number "06" and the other smooth. The drug is packaged in a box of 1 blister x 10 film-coated tablets.
Each Telfast 60mg tablet contains the following active ingredients and excipients:
Main ingredients: Active ingredient Fexofenadin Hydrochloride corresponding to 60mg content. Other excipients: Croscarmellose Sodium, Microcrystalline Cellulose (Avicel pH 101, 102), Magnesium Stearate, Pregelatinised Maize Starch, Hypromellose E-5, Titanium Dioksid, Hypromellose E-15, Povidon, Macrogol 400, Colloidal Anhydrous Silica , Yellow Iron Oxide mixture (PB1255), Pink Iron Oxid mixture (PB1254).

2. Indications and uses of the drug Telfast 60mg

2.1. Indications for use of Telfast 60mg

Telfast medicine 60mg is usually prescribed by doctors for the following cases:
Treatment of upper respiratory tract diseases, such as seasonal allergic rhinitis accompanied by symptoms of itchy throat, runny nose and sneezing . Treatment of chronic urticaria with symptoms such as itchy rash, red rash. Although medication can reduce the itch and the number of urticaria, it cannot cure the cause of the allergy. Treat certain eye disorders, such as watery or pink eyes.

2.2. What are the uses of Telfast 60mg?

Pharmacodynamics Active ingredient Fexofenadin is a 2nd generation antihistamine with specific and selective antagonism on peripheral histamine H1 receptors. It is also an active metabolite of terfenadine, however, because it does not inhibit the potassium channel involved in myocardial repolarization, the drug is no longer active on the heart.
In addition, Fexofenadin is also less likely to be anti-Dopaminergic or Cholinergic, and does not have an inhibitory effect on beta Adrenergic and Alpha-1 receptors. At therapeutic doses, this active substance does not affect the central nervous system and does not cause drowsiness in patients. Moreover, the drug also has a quick and long-lasting effect.
Pharmacokinetics Absorption
The active ingredient Fexofenadin is best absorbed by the body when taken orally. The effect of the drug will start to take effect after about 60 minutes. Peak plasma concentrations of Fexofenadine are reached after only 2 - 3 hours of dosing. When combining Fexofenadine with a high-fat diet, Cmax and AUC can be reduced by 20% and 21%, respectively.
Distribution
According to research, Fexofenadin has a plasma protein binding rate of about 60 - 70%, mainly with Alpha-1 Acid Glycoprotein and Albumin. Currently, there are no studies to determine whether the drug is excreted in breast milk or crosses the placenta. In addition, Fexofenadine is not absorbed across the blood-brain barrier.
Metabolism
Fexofenadin in the drug Telfast 60mg is very little metabolized (mainly in the intestinal mucosa - accounting for about 5%). In which, about 0.5 - 1.5% of the dose is metabolized in the liver through the Cytochrome P450 enzyme system.
Elimination
The mean half-life of the drug is usually within 14.4 hours and tends to be longer in patients with renal impairment (range 32 - 72%). Fexofenadine is eliminated mainly unchanged in the faeces (80%) and urine (11%).

3. Dosage and how to use Telfast 60mg

3.1. Dosage of Telfast 60mg

Dosage of Telfast 60mg is usually determined based on age and specific patient population, including:
Adults and children from 12 years of age and older: Take 2 tablets per day, one tablet each time. light-dark division). Children under 12 years: Do not take a dose of 60mg, Fexofenadine 30mg tablets can be used in case of necessity. Patients with hepatic impairment and the elderly: Use the normal dose, except in patients over 65 years of age with impaired renal function, the dose may need to be adjusted accordingly. Patients with renal failure: Take 1 tablet/day.

3.2. How to use Telfast 60mg?

Telfast 60mg is made in the form of tablets, so patients can take it orally. When taking the drug, you should drink it with 30 - 50ml of filtered water or boiled water to cool and use it after meals. Avoid taking the medicine with other drinks such as orange juice, milk, beer, apple juice or grapefruit.
In addition, the patient should not crush or break the tablet in half because this can reduce the ability to absorb as well as the quality of the drug when entering the body. During the use of the drug, the patient should limit the consumption of high-fat foods.

4. How to handle overdose or forget dose of telfast 60mg

In case of missed dose:
Immediately add the missed dose at the earliest time to ensure effective treatment. Skip the missed dose and take it on schedule if it is too close to the time for your next dose. Avoid taking a double dose or make up a dose at the same time to prevent the risk of drug accumulation in the body. In case of overdose:
Symptoms of overdosage with Telfast 60mg usually include dizziness, drowsiness, dry mouth and fatigue. Treatment: Hemodialysis does not completely remove the drug from the blood (1.7%), and there is currently no specific antidote, so the treatment of overdosage with Telfast 60mg is focused only on treatment. to the application of conventional measures to remove unabsorbed drug from the gastrointestinal tract. In addition, the doctor also treats the symptoms of overdose and applies supportive measures to support the patient's general condition.

5. Contraindications to using Telfast 60mg

Absolutely do not use Telfast 60mg drug for the following cases:
People who are allergic or hypersensitive to the active ingredients as well as excipients in the drug. Children under 12 years old. The patient is taking some other antihistamines.

6. Some side effects when using Telfast 60mg

In the process of using Telfast 60mg, patients may experience some side effects from common to rare below:
Common side effects:
Nervous effects, including drowsiness, headache, fatigue, dizziness or insomnia. Digestive effects such as indigestion, nausea. Menstrual pain in women, susceptible to viral infections, itchy throat, easy upper respiratory tract infections, sinusitis, otitis media, fever, cough and back pain. Uncommon side effects :
Gastrointestinal symptoms such as abdominal pain and dry mouth. Neurological symptoms such as nightmares, fears, or sleep disturbances. Rare side effects :
Skin problems such as hives, itching or rash. Hypersensitivity reactions such as chest tightness, flushing, difficulty breathing, swelling of lips/tongue/throat/face. Side effects of unknown frequency :
Diarrhea . Cardiovascular problems such as palpitations, increased heart rate. When experiencing any side effects of the drug, the patient should first stop using the drug immediately and notify the doctor or go to the medical center for assistance.

7. Interaction of Telfast 60mg with other drugs

According to research, Telfast 60mg drug often interacts with some of the following drugs:
Ketoconazole and Erythromycin leading to increased plasma concentrations of Fexofenadin, but no change in QT interval. Antacids containing magnesium and aluminum reduce the absorption of fexofenadine, so patients should take these drugs about 2 hours apart. P-glycoprotein inhibitors and the drug Verapamil lead to increased plasma concentrations of Fexofenadin. Decreased concentrations of Acetylcholinesterase and Betahistine inhibitors when co-administered with Fexofenadine. Taking Fexofenadine with alcohol leads to a sedative effect (drowsiness). When taken with antacids, Amphetamines, Acetylcholinesterase inhibitors, Rifampin or grapefruit juice may decrease Fexofenadin concentrations. Reduces bioavailability of Fexofenadine by up to 36% when taken with fruit juices (grapefruit, apples, oranges).

8. Some other notes when using Telfast 60mg

8.1. Precautions while using Telfast 60mg

Patients with severe acute renal impairment or coagulopathy should use Telfast 60mg with caution. In addition, patients should also note a number of other things as follows:
Use the correct dose of medicine prescribed by the doctor, avoid taking too much, causing drug accumulation. Avoid self-medicating during treatment because this can aggravate existing health conditions. Avoid arbitrarily using more H1 antihistamines while using Telfast 60mg. Telfast should be discontinued at least 24-46 hours before conducting intradermal antigen tests. Using Telfast 60mg can make psoriasis worse.

8.2. Special subjects to note when using Telfast 60mg

When using Telfast 60mg, the following people should be aware of:
Pregnant women: Only use the drug when the benefits outweigh the risks and only when prescribed by a doctor. Lactation: Consult a doctor as it is not known whether the drug is excreted in breast milk. Driving or operating machinery: This medicine may cause dizziness and drowsiness as an overdose or side effect. Therefore, this group of subjects needs to be especially careful when using the drug.

8.3. Telfast drug storage 60mg

Telfast 60mg medicine needs to be stored at a temperature below 30 degrees Celsius, always in a dry area, avoiding direct exposure to light from the sun. Medicines should also be stored in a cool place, away from locations that are humid or prone to mold and bacteria growth. Keep medicine out of reach of children and household pets.

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