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The drug Pariet is often used in the treatment of peptic ulcer disease. In this article, it helps to provide some information related to the drug Pariet 20mg.1. What is Pariet 20mg?
Pariet, also known as Rabeprazole, inhibits gastric juice secretion in both basal and stimulated states through inhibition of H+/K+ -ATPase enzymes. in parietal cells of the gastric mucosa.In the cells, there is a pumping system of ions on the cell membrane that helps with hydrogen or proton molecules in the parietal cells into the stomach lumen, reducing the pH level and creating an acidic environment in the stomach. Rabeprazole acts on this enzyme to help reduce gastric acid secretion, so it is also considered a proton pump inhibitor. The mechanism of action of rabeprazole is to bind to these enzymes to inhibit the final stage of gastric secretion.
2. What is the indication for Pariet?
The main indications of rabeprazole include diseases of the stomach such as:
Acute gastric ulcer Zollinger-Ellison syndrome Treatment in acute exacerbation of acute duodenal ulcer (duration of about 4 weeks) Gastroesophageal reflux disease (GERD) with or without esophagitis, ulceration or abrasion In addition, Pariet can be treated in combination with appropriate antibiotic regimens to eradicate H. pylori in patients with duodenal ulcer.
Pariet is contraindicated in patients with a history of allergy to rabeprazole or derivatives of the benzimidazole group (including lanzoprazole, pantoprazol, omeprazole) or who have had an allergic reaction to any of its ingredients. Note, Pariet (rabeprazole) should not be used in pregnant women.
4. How to use / dose of Pariet
4.1. The drug is manufactured in tablet form, so when using it, it is necessary to swallow the tablet whole, do not chew, crush or break the tablet. For the best effect, the medicine should be taken at least 30 minutes before eating.
4.2. Dosage Dosage of the drug will be prescribed according to the instructions of the doctor and will normally be divided according to each pathology
Acute duodenal ulcer can be used 20 mg / time / day in the morning. Patients can use it for 4 weeks if the ulcer is not completely healed. Benign acute gastric ulcer used at a dose of 20 mg / time / day for 6 weeks in the morning. If the ulcer is still not stable, continue to use for another 6 weeks. Gastroesophageal reflux disease with ulcerative or erosive manifestations can be used 20 mg / time / day x 4 - 8 weeks. For the symptomatic treatment of gastroesophageal reflux disease without symptoms of esophagitis, the recommended dose is 10 mg once daily for 4 weeks, followed by another 10 mg once daily maintenance. if the condition has not subsided. If there is no improvement in the patient's condition within 4 weeks, the patient should be re-examined with the doctor. Zollinger-Ellison syndrome is recommended to use an initial dose of 60 mg / time / day, a maximum dose of 120 mg / day, divided into 2 times a day depending on the severity of the patient. Your doctor may increase the once-daily dose if the dose is less than 100 mg. Duodenal ulcer and benign gastric ulcer caused by H. pylori infection will be treated according to each doctor's regimen when combined with antibiotics. Please note that the above dosages are for reference only. Patients need to follow the doctor's instructions and adhere to the exact dose prescribed by the doctor.
5. Side effects when taking Pariet
Possible side effects of Pariet medicine include:
Chest pain Chills, fever Dry mouth, erythema, belching, itching flu-like symptoms, back pain, weakness, Diarrhea, bloating pain unknown causes, nausea, abdominal pain, constipation, increased liver enzymes Restlessness, drowsiness Sore throat, rhinitis, cough Urinary tract infection Muscle pain, cramps, joint pain Insomnia , headache, dizziness
6. Drug interactions with Pariet
The effect of Rabeprazole may interfere with some drugs such as:
Erlotinib, nelfinavir, delavirdin, posaconazole Ketoconazole or itraconazole: may reduce the absorption of Methotrexate, saquinavir, voriconazole: increase effect / concentration. Atazanavir 300 mg/ ritonavir 100 mg: a sharp decrease in atazanavir concentrations. Chlorpidogrel, dabigatran, etexilate, dasatinib, erlotinib, indinavir, iron salts, itraconazole, ketoconazole, mesalamin, mycophenolate, nelfinavir: decreased effect/concentration.
7. Precautions when taking Pariet (rabeprazole)
Patients should be monitored periodically when treatment lasts more than 1 year with rabeprazole. The drug should not be used on young children. Besides, it is necessary to exclude the possibility that the patient has malignancy before treatment.
Potential health problems that may occur with the drug include:
Hematopoietic disorders: Hematopoietic disorders have been reported (thrombocytopenia and neutropenia). In most cases no cause can be found, but these disorders are not serious and resolve with discontinuation of use. Liver enzymes: Liver enzyme abnormalities have been reported from clinical trials. However, if there is no other cause, the disorder is not serious and will go away when the drug is stopped. Hepatic impairment: Extreme caution should be exercised when administering rabeprazole sodium for the first time to patients with severe hepatic impairment because of insufficient clinical data. Gastrointestinal infections: Increased risk of gastrointestinal infections with Salmonella, Campylobacter and Clostridium difficile when taking this medicine. Intolerance: Do not use rabeprazole for patients with hereditary galactose intolerance or impaired absorption of glucose, galactose. There is no evidence of safety of the drug in pregnant women Contraindicated to mothers during lactation. It is not known whether rabeprazole is excreted in milk. Therefore, the drug should not be used in this population because of the risk of harm to the fetus.
8. Treatment of overdose with Pariet (rabeprazole)
There are currently no reports of clinical signs or symptoms in cases of overdose. Therefore, there is still no specific antidote in case of overdose.
Rabeprazole is highly protein bound and therefore cannot be eliminated by dialysis. In case of overdose, priority should be given to symptomatic and supportive treatment.
When you forget a dose of Pariet (rabeprazole) you need to take it as soon as you remember. If it is almost time for your next dose, skip it and follow your dosing schedule. You should not double the dose of rabeprazole because the effectiveness is not increased, but the risk of side effects is increased.
9. How to store Pariet
Store at a suitable temperature, preferably no more than 25 oC Keep the medicine out of reach of children and pets in the house Do not expose the medicine to direct light and moisture For expired medicine used, please dispose of it and do not use it for therapeutic purposes. However, you need to ask the pharmacist about how to dispose of expired medicine before releasing it into the environment. Pariet is a brand name drug containing the active ingredient rabeprazole, which is used in cases of acute gastric ulcer, gastroesophageal reflux disease, .. Because the drug is an inhibitor of acid secretion, long-term use can cause many effects. Side effects such as gastrointestinal infections, vitamin deficiencies due to reduced absorption. Therefore, it is advisable to see a gastroenterologist for advice and support during treatment.
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