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Klamentin 875/125 is commonly used in the treatment of a number of infections of the respiratory tract, urinary tract, skin, soft tissue, bone and joint infections. Depending on the therapeutic purpose, the recommended dose of Klamentin 875/125 is different.
1. What does Klamentin 875/125 do?
Klamentin 875/125 medicine has the main ingredients Amoxicillin (as amoxicillin trihydrate) 875mg and clavulanic acid (as potassium clavulanate) 125mg.
Amoxicillin is a semi-synthetic beta-lactam antibiotic with a broad bactericidal spectrum against many Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis. But the active ingredient Amoxicillin is easily destroyed by beta-lactamase enzymes, so it has no effect on bacterial strains that produce these enzymes.
And ClavuLanic Acid has a beta - lactam structure similar to Penicillin, it has the ability to inhibit beta - lactamase enzymes produced by most Gram-negative bacteria and Staphylococcus. In particular, clavulanic acid has a strong inhibitory effect on plasmid-transmitted beta-lactamase enzymes that cause resistance to penicillins and cephalosporins.
The combination of ClavuIanic acid and Amoxicillin in Klamentin 875/125 prevents Amoxicillin from being destroyed by beta-lactamases, and at the same time effectively expands the antibacterial spectrum of Amoxicillin against many types of bacteria normally resistant to Amoxicillin, other penicillins and also Aephalosporin drugs.
2. Indications and contraindications of Klamentin 875/125
The antibiotic Klamentin 875/125 is indicated for short-term treatment:
Upper and lower respiratory tract infections; Urinary tract infections ; Skin and soft tissue infections, bones and joints. Klamentin 875/125 is contraindicated in the following cases:
Hypersensitivity to Penicillins and Cephalosporins; Severe liver and kidney failure; History of jaundice or liver dysfunction while taking penicillin; Infectious mononucleosis. Note when using Klamentin 875/125 in patients with renal failure. Prolonged treatment with this drug can cause superinfection.
3. Dosage and how to use Klamentin 875/125
Dosage of Klamentin 875/125 is calculated according to Amoxicillin, you should take it right before meals to minimize drug intolerance in the gastrointestinal tract.
Severe infections in adults and children over 12 years old, use Klamentin 875/125 with a dose of 1 tablet / time x 2 times / day.
The duration of treatment with Klamentin 875/125 lasts from 5 to 10 days, not to exceed 14 days without re-examination.
4. Side effects of Klamentin 875/125 Common side effects of Klamentin 875/125 include:
Diarrhea; Vomit; Nausea. Uncommon side effects of Klamentin 875/125 include:
Eosinophilia; Hepatitis ; Cholestatic jaundice; Itching, erythema, rash. Rare side effects of Klamentin 875/125 include:
Anaphylactic reactions; Quincke's edema; Thrombocytopenia; Leukopenia; Hemolytic anemia ; Pseudomembranous colitis ; Stevens - Johnson syndrome ; Interstitial nephritis.
5. Interactions with other drugs
Probenecid when used with Klamentin 875/125 will reduce the excretion of Amoxicillin in the renal tubules, so it will increase the concentration of Amoxicillin in the blood; Klamentin 875/125 may prolong bleeding and clotting time; Klamentin 875/125 might decrease the effects of oral contraceptives. In summary, Klamentin 875/125 is an antibiotic used for the short-term treatment of bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints. You need to use the medicine exactly as prescribed by the doctor to promote the effectiveness of treatment and ensure safety for health.
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