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Kagasdine medicine 20mg is a product with the main active ingredient, Omeprazole, used in the treatment of a number of gastrointestinal diseases. To ensure the effectiveness of treatment and avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
1. What is Kagasdine 20mg?
Kagasdine medicine 20mg is a product whose main active ingredient is Omeprazol. The drug is indicated for use in diseases of the gastrointestinal tract such as stomach ulcers, duodenal ulcers, gastroesophageal reflux disease or Zollinger-Ellison syndrome.
Kagasdine medicine 20mg is prepared in the form of enteric-soluble capsules and packed in boxes of 10 blisters x 10 tablets.
2. What are the effects of Kagasdine 20mg?
Kagasdine 20mg is indicated for patients with one of the following diseases:
Peptic ulcer disease. Gastroesophageal reflux . Zollinger-Ellison syndrome.
3. Pharmacokinetics and pharmacodynamics of Kagasdine 20mg
Omeprazole is an active ingredient that inhibits gastric acid secretion by reversible inhibition of the proton pump (hydrogen-potassium adenosine triphosphatse enzyme system) in the parietal cells of the stomach. This process of inhibition is long-lasting and has a quick effect, but the advantage is that it is reversible. The outstanding feature of Omeprazole is that it has no effect on acetylcholine receptors or histamine receptors. The effect of the drug reaches its maximum after 4 days of use.After 3 to 6 hours of oral administration, Omeprazole is completely absorbed in the small intestine with a bioavailability of approximately 60%. Intestinal absorption is not affected by food.
In addition, absorption of the drug is dose-dependent by increasing absorption by inhibiting gastric acid secretion. The drug is able to bind up to 95% to plasma proteins and is uniformly distributed in tissues, especially gastric parietal cells.
After taking the first dose, bioavailability is only about 35% and will increase to about 60% with subsequent administration of one dose per day. Although the half-life is short, with only about 40 minutes, with a prolonged inhibitory effect on acid secretion only once daily.
The drug is completely metabolized in the liver and eliminated quickly with 80% in the urine, the rest in the feces.
4. How to use Kagasdine 20mg
The drug is taken orally. The time to drink can be before breakfast or at night before going to bed. Dosage varies depending on the disease:
4.1. Duodenal ulcer Patients take 1 tablet * 1 time / day, the duration of drug use lasts from 2 to 4 weeks. Severe cases can use 2 tablets * 1 time / day for 4 weeks.
4.2. Gastric ulcer, gastroesophageal reflux Use 1 tablet * 1 time / day for 4 to 8 weeks.
In case of severe disease, you can take 2 tablets * 1 time / day for 8 weeks.
4.3. Zolinger - Ellison syndrome Initial dose with 3 tablets * 1 time / day. Maintenance dose from 1 to 6 tablets / day depending on the clinical condition of the patient For doses above 4 tablets / day, it should be divided into 2 oral doses. Note that the above dosage is for reference only. Depending on the condition of the patient and the severity of the disease, the doctor will prescribe the appropriate dose. Therefore, before using it, it is necessary to consult a doctor for the best effect.
5. Some notes when using the drug Kagasdine
Kagasdine 20mg is contraindicated in patients with a history of hypersensitivity to Omeprazole or any of its ingredients. The possibility of malignancy must be excluded before administering Omeprazole to patients with peptic ulcer disease, as it may mask symptoms and lead to delayed diagnosis. Kagasdine medicine 20mg is a product with the main active ingredient, Omeprazole, used in the treatment of a number of gastrointestinal diseases. To ensure the effectiveness of treatment and avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
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