Uses of Dafrazole

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1. What is Dafrazol?

Dafrazol 20mg drug has the main ingredient Omeprazole 20mg. Omeprazole works by inhibiting the proton pump PPIs in gastric parietal cells, helping to reduce gastric acid secretion. Omeprazole acts on the terminal phase of acid secretion, a single dose of 20 mg/day rapidly inhibits gastric secretion induced by any stimulant. The drug has no anti-inflammatory effect, causing few side effects, so it is effective in supporting the treatment of diseases caused by excessive secretion of stomach acid (such as duodenal ulcer).
Indications to use Dafrazol:
Treatment of gastric and duodenal ulcers; Support to improve gastric reflux in patients with reflux esophagitis; Treatment of patients with Gastrinoma tumors in the stomach due to Zollinger-Ellison syndrome. Contraindications to the use of Dafrazol:
Patients with hypersensitivity to Omeprazole, esomeprazole, other benzimidazole derivatives (pantoprazol, lansoprazole, rabeprazol) or any of the ingredients in the drug.

2. How to use and dose Dafrazole

How to use: Dafrazol is made in the form of hard capsules, so patients can take it orally. When taking orally, patients should avoid breaking, crushing or chewing the tablet, but should take the tablet whole with 1 glass of water. Patients should take the drug in the morning and not with food to promote the best therapeutic effect.
Dosage:
Reduce symptoms of acid indigestion: Take a dose of 10-20mg/day, treat for 2-4 weeks; Treatment of gastroesophageal reflux disease - oesophagitis: Usual dose: 20mg/time/day for 4 weeks treatment. If the disease is not completely cured, the drug should be taken for another 4 - 8 weeks. In case of persistent esophagitis, patients can take up to 40mg/day; Maintenance dose after recovering from esophagitis: Use dose 20mg/time/day, with acid reflux is 10mg/day; Treatment of peptic ulcers: Usual dose: 20mg/day or 40mg/day for severe disease. After that, continue treatment for 4 weeks if it is duodenal ulcer, 8 weeks if it is gastric ulcer; Maintenance dose: Use dose 10 - 20mg/time/day; Eradicating Helicobacter Pylori in peptic ulcers: Using combination of Omeprazole with other antibiotics in 2 or 3 drug therapy: 2 drug therapy: Omeprazole 20mg/time x 2 times/day, treatment for 2 weeks; Triple therapy: Omeprazole 20mg/time x 2 times/day, treatment for 1 week; Treatment of gastric ulcers caused by non-steroidal anti-inflammatory drugs: 20mg/day. In addition, a dose of 20mg/day is also used for prevention in patients with a history of gastroduodenal injury requiring continued non-steroidal anti-inflammatory drug therapy; Zollinger - Ellison syndrome: Use dose 60mg/time/day, adjust as necessary. The majority of patients have effective disease control at doses ranging from 20 to 120 mg/day but may require doses up to 120 mg/time x 3 times/day. For patients taking a dose of over 80mg/day, it should be divided into 2 times; Prevention of acid aspiration during general anesthesia: 40 mg the evening before surgery, an additional 40 mg 2 to 6 hours before surgery. Dosage for special groups:
Patients with impaired renal function: No dose adjustment is required; Patients with liver failure: Use dose 10 - 20mg/day; Elderly (over 65 years old): No dose adjustment is required; Children: There is not much experience with Omeprazole in children.

3. Dafrazole side effects

When using Dafrazol, patients may experience some side effects such as:
Common: Drowsiness, headache, dizziness, nausea, vomiting, abdominal pain, constipation, diarrhea, abdominal distension ; Uncommon: Confusion, insomnia, fatigue, dizziness, skin pruritus, urticaria, rash, reversible elevation of transaminases; Rare: Sweating, hypersensitivity (including angioedema and anaphylaxis), peripheral edema, thrombocytopenia, leukopenia, agranulocytosis, pancytopenia, gynecomastia in men, reversible confusion, agitation, depression, hallucinations, hearing disturbances, gastritis, dry mouth, candidiasis, hepatitis, encephalopathy in liver failure, bronchospasm, myalgia, pain Arthritis, interstitial nephritis,... Patients should still notify their doctor if they have unusual, prolonged, or health-affecting symptoms for advice on timely treatment.

4. Precautions when using Dafrazole

Some notes patients need to remember before and while taking Dafrazol:
Use the right medicine and the dose prescribed by the doctor. Patients should not arbitrarily reduce the dose, because it may make the drug ineffective or increase the dose to speed up the treatment process. Increasing the dose too high can lead to an overdose and cause some dangerous side effects; If the patient has symptoms such as prolonged vomiting, heavy weight loss, difficulty swallowing, vomiting blood, black stools, etc., suspected of having a stomach ulcer, it is necessary to exclude the possibility of malignancies, because the treatment with dafrazol can reduce symptoms and delay diagnosis; Severe hypomagnesemia has been reported with proton pump inhibitors for at least 3 months (in most cases about 1 year). Symptoms may occur such as muscle spasms, fatigue, convulsions, delirium, dizziness, ventricular arrhythmias, ... (or insidious, unnoticed). Most patients with hypomagnesemia improve upon magnesium supplementation and discontinuation of proton pump inhibitors; It is advisable to measure magnesium levels before initiating therapy and periodically during use in patients requiring long-term therapy or requiring concomitant use of proton pump inhibitors with digoxin or diuretics (possibly cause hypomagnesemia); Use of proton pump inhibitors, especially when used in high doses and for long periods of time (more than 1 year), may slightly increase the risk of fractures of the spine, hip, and wrist (mainly in humans). elderly or have other risk factors). Therefore, patients at risk of osteoporosis should be cared for according to existing guidelines and fully supplemented with calcium and vitamin D; Although research shows that Omeprazole is not capable of causing malformations and toxicity to the fetus, it is still necessary to use caution when using Dafrazol in pregnant women or nursing mothers; If you experience dizziness or visual disturbances while taking Dafrazol, you should not drive or operate machinery.

5. Dafrazole drug interactions

Dafrazol is used orally, is absorbed and tolerated by the body. Once in the body, a number of interactions between drugs and food or other drugs can occur, creating beneficial or harmful reactions, increasing or decreasing the bioavailability of the drug, increasing or decreasing toxicity. or side effects. Therefore, patients should list the drugs they are using and notify the doctor for appropriate adjustment, to avoid the risk of adverse drug interactions.
Some drug interactions of Dafrazo include:
Co-administration of Dafrazol with atazanavir is not recommended. If the combination is necessary, it is necessary to closely monitor the clinical manifestations such as viral infection, in combination with increasing the dose of atazanavir to 400mg and 100mg of ritonavir, without increasing the dose of Omeprazol; Omeprazole may decrease the absorption of vitamin B12 by reducing or lacking hydrochloric acid. Therefore, this factor should be considered in patients with reduced body stores or at risk of reduced absorption of vitamin B12 if using the drug for a long time; Omeprazole is an inhibitor of CYP2C19. When starting or ending treatment with omeprazole, the risk of drug interactions with drugs metabolised by CYP2C19 should be considered. In addition, drug interactions between Clopidogrel and Omeprazole should be monitored, it is best not to use these two drugs at the same time. When using Dafrazol, patients should strictly follow the instructions and instructions of the doctor to ensure the highest treatment effectiveness and significantly reduce the risk of adverse side effects.
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