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Cefixim is a 3rd generation cephalosporin antibiotic widely used orally effective in many different inflammatory diseases. One of the drugs containing this ingredient on the market is Fudcime 200mg. So what does fudcime 200mg do?
1. What is Fudcime 200mg?
Fudcime 200mg drug has the main ingredient Cefixim, with a content of 200mg, which is prepared in the form of tablets.
Cefixim is a 3rd generation cephalosporin antibiotic, used orally for bactericidal action, the bactericidal mechanism is similar to that of other cephalosporins, the drug will bind to target proteins (penicillin-binding proteins) and cause inhibition. Inhibits mucopeptide synthesis in bacterial cell walls. The mechanism of bacterial resistance to Cefixime is either a decrease in the pressure of Cefixime on the target protein or possibly a decrease in the permeability of the bacterial cell membrane to the drug.
Cefixim has high stability to hydrolysis of beta - lactamase encoded by genes located on plasmid and chromosome, this stability of Cefixim is higher than cefaclor, cefoxitin, cefuroxime, cephalexin, cephradine... used both in vitro and clinically with most of the following bacterial strains:
Gram-positive bacteria: Streptococcus pneumonia, Streptococcus pyogenes; Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae. Cefixime is also active in vitro against strains of the following bacteria:
Gram-positive bacteria: Streptococcus agalactiae; Gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp, Salmonella spp, Shigella spp, Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens. Cefixime is not active against Enterococcus, Staphylococcus, Pseudomonas aeruginosa and most strains of Bacteroides, Clostridia.
After taking a single dose of Cefixime, only 30 - 50% of the dose is absorbed from the gastrointestinal tract, taking before or after meals does not affect drug absorption. However, the rate of absorption may be reduced when Cefixime is taken with meals. Cefixime can cross the placenta.
2. What are the effects of Fudcime 200mg?
Fudcime 200mg is indicated for use in the following cases:
Upper and lower respiratory tract infections; Acute otitis media ; Urinary tract infections; gonococcal urethritis; Nephritis - pyelonephritis, uncomplicated gonorrhea; Typhoid ; Dysentery.
3. Dosage of Fudcime 200mg
Fudcime 200mg for oral use with the following dosage:
Adults and children over 12 years old: The usual dose of Fudcime 200mg is 400mg/day, can be taken once or divided into 2 times, each time 12 apart. hours; Children 6 months - 12 years old: Use Fudcime 200mg at a dose of 8mg/kg/day, can be taken once or divided into 2 times, each time 12 hours apart. Treatment of uncomplicated gonorrhea: a single dose of 400mg/day or may be divided into 2 times/day.
Note: The above dosage of Fudcime 200mg is for reference only, the specific dose depends on the condition and the progression of the disease, patients need to consult a doctor or medical professional before taking it. Fudcime 200mg.
4. What to do when overdosing Fudcime 200mg?
When Cefixime overdose can lead to convulsive symptoms, then it is necessary to stop the drug immediately and treat gastric lavage, anticonvulsants can be used if clinically indicated. Fudcime 200mg drug cannot be removed by hemodialysis, so hemodialysis or peritoneal dialysis is not usually used.
5. Fudcime 200mg . side effects
When using Fudcime 200mg, patients may experience undesirable effects, but the side effects that occur are usually mild and self-limiting: diarrhea, abdominal pain, nausea, pseudo-conjunctivitis, Headache, dizziness, skin allergy, urticaria, pruritus are very rare.
6. Contraindications of Fudcime 200mg
Fudcime 200mg is contraindicated for use in the following cases:
Patients with hypersensitivity to any component of Fudcime 200mg or other cephalosporin antibiotics; History of anaphylaxis due to penicillin. Children under 6 months old.
7. Caution when taking Fudcime 200mg
Fudcime 200mg should be used with caution in patients with hypersensitivity to penicillins and other cephalosporins due to cross-sensitivity between beta-lactam antibiotics, including: penicillins, cephalosporins and cephamycins. Fudcime 200mg should be used with caution in people with a history of gastrointestinal disease and colitis, especially with prolonged use. The dose of Fudcime 200 mg should be reduced in patients with renal failure, including those undergoing extra-renal dialysis. For the elderly: In general, no dose adjustment of Fudcime 200mg is required unless there is impaired renal function. Pregnant and lactating women should only take Fudcime 200mg when absolutely necessary. Studies in pregnant mice and rats with oral doses of Cefixime up to 400 times the usual human therapeutic dose found no evidence of harmful effects on the fetus. However, to date, there are no adequate research data on the use of Cefixime in pregnant women, during labor and delivery, so Cefixim should only be used in these cases when absolutely necessary.
At present, it is not certain whether Cefixime is distributed into breast milk in lactating women, so Fudcime 200mg should only be used with caution in lactating women. breast-feeding while taking Fudcime 200mg.
8. Drug interactions of Fudcime 200mg
Co-administration of Fudcime 200mg with Probenecid increased the peak concentration and AUC of Cefixime, decreased renal clearance and volume of distribution;
Anticoagulants such as warfarin, when taken with Fudcime 200mg, increase prothrombin time, with or without bleeding;
Carbamazepine taken with Fudcime 200mg increased the plasma concentration of Carbamazepine.
Nifedipine when co-administered with Fudcime 200mg increases the bioavailability of Cefixime manifested by an increase in peak concentration and AUC.
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