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Minopecia belongs to the group of drugs used to treat parasites, infections, viruses and fungi. The drug is prepared in the form of powder for oral suspension, packing specifications: Box of 10 packs x 3 grams. Let's refer to some information about Minopecia that will help you know how to use the drug most appropriate.
1. What does Minopecia do?
Minopecia medicine contains the main ingredient is Cefpodoxime 50mg (in the form of Cefpodoxime proxetil). The antibacterial action of Cefpodoxime is through inhibition of bacterial cell wall synthesis by acylation of membrane-bound transpeptidase enzymes. By this mechanism, Cefpodoxime prevents the cross-linking of peptidoglycan chains essential for bacterial cell wall strength and durability.
Cefpodoxime is active against Gram-negative and Gram-positive bacteria, stable to β-lactamases. The antibacterial spectrum of Cefpodoxime includes Staphylococcus aureus (except for Methicillin-resistant Staphylococci), Streptococcus agalactiae, Streptoccocus pyogenes, Streptococcus pneumoniae, Streptococcus spp. other (Group C, G, F). Cefpodoxime-susceptible Gram-negative bacteria include H. influenzae and non-β-lactamase producing strains, Moraxella catarrhalis, Neisseria meningitidis, Neisseria gonorrhoea, E. coli, H. para-influenzae, Klebsiella pneumoniae, Providencia rettgeri, Proteus vulgaris and Citrobacter diversus. Cefpodoxime is also effective against Peptostreptococcus spp.
After oral administration, Cefpodoxime is rapidly absorbed and hydrolyzed. Cefpodoxime enters the bloodstream and after a dose of 100 mg, mean peak plasma concentrations of 1.4 mg/ml are reached in about 2 hours. When Cefpodoxime is taken with food, the extent of absorption and mean peak plasma concentrations are increased, binding to plasma proteins is about 29%. The plasma half-life of Cefpodoxime is approximately 2.8 hours.
2. Indications for use of Minopecia
Minopecia is indicated in the treatment of mild to moderate infections caused by susceptible strains of bacteria, which are:
Treatment of lower respiratory tract infections: Community-acquired pneumonia caused by strains of S. pneumoniae or H. influenzae (including β-lactamase-producing strains) causes; Acute exacerbation of chronic bronchitis caused by strains of S.pneumoniae, M. catarrhais, H.influenzae (including only strains that do not produce β-lactamase). Upper respiratory tract infections: Acute maxillary sinusitis caused by Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis, Streptococcus pneumoniae. Acute otitis media caused by Streptococcus pneumoniae, Moraxella (Branhamella) catarrhalis, Haemophilus influenzae (including β-lactamase-producing strains). Pharyngitis, tonsillitis caused by Streptococcus pyogenes. Treatment of sexually transmitted diseases: Acute uncomplicated cervical and urethral gonorrhea caused by Neisseria gonorrhoeae (including penicillinase-producing strains). Acute anorectal infection with Neisseria gonorrhoeae (including penicillinase-producing strains) in uncomplicated female subjects. Skin and Skin Structure Infections: Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (including penicillinase-producing strains) or Streptococcus pyogenes. Urinary tract infections: Uncomplicated urinary tract infections caused by Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae or Staphylococcus saprophyticus. Prior to treatment with Minopecia, appropriate bacteriological tests should be performed to isolate and determine the causative organism and their susceptibility to cefpodoxime. Once accurate test results are available, antibiotic therapy should be tailored to the patient's condition.
3. Dosage, how to use Minopecia
How to take Minopecia:
It is recommended to take the drug with food to increase the absorption of Minopecia. Dosage of Minopecia for adults and adolescents 12 years of age and older:
Treatment of acute community-acquired pneumonia: 400mg/200mg every 12 hours for 14 days. Treatment of acute exacerbations of chronic bronchitis: 400mg/200mg every 12 hours for 10 days. Treatment of acute maxillary sinusitis: 400mg/200mg every 12 hours for 10 days. Treatment of pharyngitis and/or tonsillitis: 200mg/100mg every 12 hours for 5-10 days. Treatment of uncomplicated gonorrhea (male/female) and rectal gonorrhea (female): Use 200mg as a single dose. Treatment of uncomplicated skin and soft tissue infections: Use a dose of 800mg / 400mg / every 12 hours for 7-14 days. Treatment of uncomplicated urinary tract infections: 200mg/100mg every 12 hours for 7 days. Dosage of Minopecia in Renal Impairment: In patients with severe renal impairment, creatinine clearance < 30 mL/min, the dosing interval should be increased to 24 hours. For patients on hemodialysis, the Minopecia dosing interval is 3 times/week, taken after dialysis. Minopecia Dose for Cirrhotic Patients: No dose adjustment of Minopecia is required for these patients. Minopecia dose for children and pediatric patients from 2 months to under 12 years old:
Treatment of acute otitis media: Minopecia dose 10mg/kg/day (maximum 400mg/day)/5mg/kg every 12 hours (maximum 200mg) /dose) within 5 days; Treatment of pharyngitis and/or tonsillitis: Minopecia 10mg/kg/day (maximum 200mg/day)/5mg/kg/dose every 12 hours (maximum 100mg/dose) for 5-10 days; Treatment of acute maxillary sinusitis: Minopecia 10mg/kg/day (maximum 400mg/day)/5mg/kg every 12 hours (maximum 200mg/dose) for 10 days. The above dose of Minopecia is for reference only. The specific dose of Minopecia will depend on your condition and how advanced the disease is. To get the right dose of Minopecia, patients need to consult their doctor/pharmacist.
4. Contraindications to taking Minopecia
Minopecia is contraindicated in patients allergic to cefpodoxime or other cephalosporin antibiotics.
5. Interactions with other drugs
Possible interactions when using Minopecia concurrently with the following drugs:
Antacids; Probenecid; Drugs that are toxic to the kidneys. To avoid unwanted interactions when using Minopecia, patients should inform their doctor/pharmacist of all medications, supplements, vitamins and herbs they are taking.
6. Minopecia side effects
During the use of Minopecia, patients may experience some mild and transient gastrointestinal side effects such as:
Diarrhea; Liquid stools; Stomachache ; Nausea; Undigested; Bloating, abdominal distension. During the course of treatment, if there are any abnormal symptoms suspected of using Minopecia, the patient should notify the treating doctor/pharmacist for timely treatment.
Above is information about uses, doses and precautions when using Minopecia. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Minopecia exactly as directed by your doctor.
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