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Excipients play an extremely important role in the development of vaccines. Vaccines need to combine with adjuvants to create a healthy immune system so that the body can "defeat" foreign pathogens. So what are excipients, what are the uses of excipients in drugs?
1. What are excipients?
Excipients are considered as an additive, used in the technological processes of pharmaceutical production. Excipients do not have the effect of treating disease, but these are just ingredients that are often combined to create drugs or vaccines. With drugs, this is a product with very strong pharmacological properties, so to reduce the level, one will combine with excipients.
When excipients are not combined with drugs or vaccines, excipients have no effect to cure disease. Therefore, when combining excipients in the drug, it will help the drug to be stable, the active ingredient will go to the right places, and maximize the therapeutic effect of the drug.
2. Uses of adjuvants in vaccines
Excipients are also an important ingredient in vaccine doses. The incorporation of adjuvants into vaccines results in a higher effective dose of the vaccine, increasing the number of necessary healthy immune system responses for the patient.
In vaccines there is a small amount of germ protein, to ensure that when the vaccine is injected into the body, the human immune system can be strong enough to fight off viruses and pathogens, the manufacturer will give adding adjuvants to the vaccine during the preparation process, thereby promoting the effect of the vaccine will be more effective:
Accelerate and direct the immune response Enhance the creation of cross-reactions Reduce the amount of resistance source and number of doses needed
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Monophosphoryl Lipid A Poly (I: C) CpG DNA adjuvant Emulsion Granular adjuvant This excipient is formed, grows into granules, very small in size, when entering the body, it will help stimulate the patient's immune system, distribute antigens to immune cells. Some common excipients in the form of granules can be mentioned as:
Alum Cytokine virus 2.2 Excipients combination When a single excipient is combined into the drug, it is not enough to respond to the immune system to protect the body, can Apply a combination of many excipients to improve the situation.
Uses of excipients in drugs During the production of drugs, excipients play an important role:
Help solvents dissolve organic substances, break down acids, help produce drugs faster, help fight oxidation, Excipients is a buffer to help adjust the pH to help stabilize the drug. Antiseptic properties are found in bottled antiseptic products. Excipients are like an additive to help stabilize and complete the treatment, support the delivery of the necessary active ingredients. needed in the drug to the right organ to be treated. Types of excipients included in the composition of the drug The types of excipients commonly included in the composition of the drug can be listed as:
Anti-adhesive: helps the tablets to be put together in a box not to stick together Adhesive: helps to bind the ingredients in the medicine Solubilizer: helps the medicine to break down easily, easy to be absorbed into the body Coating agent: helps the medicine to avoid moisture, reduces the unpleasant smell from the medicine Fragrance: the pleasant smell of the medicine will make it easier to drink, especially for young children
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3. Do any vaccines or drugs need an adjuvant?
Knowing that combining excipients into a drug or vaccine will maximize the effectiveness of the product, but there are many preventive vaccines that can be made from weakened bacteria and still respond to the immune system. epidemics such as: vaccines against measles, mumps, chickenpox, influenza, ..
Once we understand the ingredients of the drug as well as the excipients in the drug, we should consider and follow the instructions for use. as well as prescribed by a medical professional.
If you need advice on drug use or have a need for medical examination and treatment, customers can contact Vinmec International General Hospital, one of the hospitals that ensures good professional quality with A team of leading doctors, a system of modern equipment and technology, and the most comprehensive medical examination, consultation and treatment service today.
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