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Grapefruit juice is one of the drinks that are commonly used every day, but it is not recommended to use grapefruit juice while taking medicine to treat some diseases, because there are some ingredients that make grapefruit interact with drugs. cause adverse effects on the patient's health.1. Learn about grapefruit juice
Grapefruit juice is a healthy drink, because grapefruit is rich in vitamin C and potassium, which are nutrients necessary for the body to function and develop normally. However, grapefruit juice would not be recommended if the patient is taking medication, as it can interfere with the drug's action, especially if the patient is suffering from high blood pressure and cardiac arrhythmias. . Grapefruit juice can interact with many medications, including prescription and over-the-counter drugs, so before taking any medication, patients should be carefully advised about their diet. medication time with a treating doctor or pharmacist with expertise in this area. Some drugs that grapefruit can cause interactions are:Cholesterol-lowering Statins such as Simvastatin, Atorvastatin. Medicines for high blood pressure such as Nifedipine Organ rejection drugs Anti-anxiety drugs such as Buspirone Corticosteroid drugs Antiarrhythmic drugs Antihistamines.
Nước ép bưởi không được khuyên dùng nếu bệnh nhân đang uống thuốc
2. How does grapefruit interact with drugs?
Grapefruit interacts with drugs but not all of the above groups of drugs and the severity also varies from case to case, depending on the patient's medical condition, the type of drug and the amount of grapefruit juice given. into the body. More specifically, if you drink a lot of grapefruit juice while taking cholesterol-lowering statins, it can increase your risk of liver and muscle damage, eventually leading to kidney failure. Some other drugs, when broken down in the body, require the activity of the enzyme CYP3A4 in the small intestine, when drinking grapefruit juice can block the activity of this enzyme, causing the drug to be metabolized in the small intestine instead. will go straight into the blood in a very large amount, stay in the body for too long, increasing the side effects of the drug as well as not promoting the maximum therapeutic effect on the patient.Because the amount of CYP3A4 enzyme in the small intestine is completely different in each individual, the effect of grapefruit juice on drug breakdown is also different in patients when taking the same drug. On the other hand, some seasonal allergy medications that are high in fexofenadine, when taken with grapefruit juice or other fruit juices, can increase blood levels of this substance, thereby reducing its effectiveness. medicine. Therefore, it is always advised not to take the medicine with juice as noted on the packaging of this medicinal product. The reason is that grapefruit juice can affect the proteins that are drug transporters in the body, causing this transport channel to change and make less drugs enter the blood, thereby not being able to effectively treat the disease.
Nếu uống nhiều nước ép bưởi khi đang dùng thuốc Statin giảm Cholesterol máu thì có thể làm tăng nguy cơ tổn thương gan và cơ, cuối cùng dẫn đến suy thận
3. Can you eat grapefruit if you take medicine?
When swallowed, the drug will be broken down by enzymes or absorbed by transporters in the intestine. Therefore, drinking grapefruit juice during this period will cause problems with enzymes as well as transporters, causing too much or too little drug to enter the body. That is why many doctors recommend that patients should not drink grapefruit juice while taking medication.Although there are many nutrients for the body, grapefruit juice is not recommended when the patient is being treated with certain drugs. Grapefruit interacts with drugs, affecting the patient's absorption of drugs, causing too much or too little medicine to enter the bloodstream, which can cause unwanted effects.
Besides, in order for the drug to have a good effect in the treatment of diseases, patients should consult pharmacists and doctors before using. Taking medicine exactly as directed always brings positive effects to health.
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References: healthline.com - .fda.gov - nhs.uk - webmd.com
