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Zurampic is a drug that reduces blood uric acid when hyperuricemia in patients with gout is not well controlled on monotherapy. Let's learn about the uses, how to use and note when using the drug through the article below.
1. What does Zurampic do?
Ingredients Zurampic has the main ingredient is lesinurad 200ng, prepared in the form of film-coated tablets. It is a selective uric acid reabsorption inhibitor. Zurampic is indicated in combination with xanthine oxidase inhibitors for the treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels. when used with a xanthine oxidase inhibitor alone.
2. How to use and dose Zurampic
How to use: The drug is taken orally, the patient needs to take this medicine with a lot of water. The drug should be taken in the morning with food. The drug should be used concomitantly with xanthine oxidase inhibitors, including allopurinol or febuxostat.
Dosage:
The recommended dose of Zurampic is 200 mg (1 tablet) once daily. This is also the maximum daily dose. The use of Zurampic is not recommended for patients receiving daily allopurinol doses less than 300 mg (or doses less than 200 mg in patients with creatinine clearance less than 60 mL/min). If treatment with a xanthine oxidase inhibitor such as Allopurinol is interrupted, then Zurampic should also be interrupted. Failure to follow these instructions may increase the risk of kidney events. When taking the drug, the patient should drink with plenty of water and should drink at least 2 liters of water per day. Patients with renal impairment:
No dose adjustment is required in patients with mild or moderate renal impairment when creatinine clearance is 45 mL/min or higher). Zurampic should not be started in patients with creatinine clearance less than 45 mL/min. If gout flares occur during treatment:
Gout flares may occur after starting treatment with urate-lowering drugs, including Zurampic. Due to changes in serum uric acid concentration leads to mobilization of urate from deposited tissue. The use of drugs for the prevention of gout flares when initiating Zurampic is recommended according to practice guidelines. If a gout flare occurs during treatment with Zurampic, discontinuation is usually not necessary. Gout flares should be monitored, managed, and treated individually.
3. When is Zurampic contraindicated?
Zurampic should not be used in the following cases:
Zurampic is not recommended for the treatment of asymptomatic hyperuricemia. Zurampic should not be used as monotherapy to control uric acid levels. Do not use Zurampic if the patient is sensitive to any of the ingredients. Have severe kidney disease or you are on dialysis or have had a kidney transplant; Have Lesch-Nyhan syndrome (this is an inherited condition that increases uric acid levels in the blood); or You have tumor lysis syndrome (the rapid breakdown of cancer cells during treatment). Not intended for use by persons under 18 years of age.
4. What side effects does Zurampic cause?
Zurampic drugs cause unwanted effects as follows:
Common Zurampic side effects may include: Abnormal kidney function tests; Heartburn ; Headache; or flu-like symptoms. Call your doctor at once if you have: Symptoms of a gout flare-up such as joint pain, stiffness, redness, or swelling, especially at night; kidney problems such as urinating little or no urine, swelling in your feet or ankles, feeling tired or short of breath; heart problems such as chest pain or tightness, chest pain that spreads to your jaw or shoulder; or signs of a blood clot that appear suddenly, such as numbness or weakness. Vision problems or difficulty speaking, swelling or redness in the arms or legs. Get emergency medical help if you have signs of a serious allergic reaction to Zurampic: Hives ; shortness of breath; swelling in the face; swelling of the lips, tongue, or throat. These are not the complete side effects of Zurampic. During use, you may experience other side effects, so you need to inform your doctor about side effects for timely treatment.
5. Things to keep in mind when taking Zurampic
Things to keep in mind when taking Zurampic:
Before taking Zurampic to make sure it is safe for you, tell your doctor if you have a history of allergies, kidney disease, liver disease, heart disease; or gastroesophageal reflux disease (GERD). Evaluation of renal function is recommended prior to initiation of treatment with Zurampic and periodically thereafter. More frequent monitoring of renal function is recommended in patients with creatinine clearance less than 60 mL/min. Use should be discontinued when creatinine clearance is continuously below 45 mL/min. An increased risk of acute kidney injury has been reported when this drug is used with xanthine oxidase inhibitors. Therefore, it should be used with extreme caution in patients with pre-existing kidney disease. Adhere to taking the right medication at the right dose and at the right time. Do not stop taking your medicine without consulting your doctor. At the beginning of taking the drug, it is necessary to use more drugs to prevent acute gout attacks. If an acute gout attack occurs, you need to notify your doctor and receive appropriate treatment. It is not known whether Zurampic can harm an unborn baby. So let your doctor know if you are pregnant or plan to become pregnant. Zurampic can also make birth control pills less effective. Ask your doctor about using a non-hormonal combined birth control method (condom or diaphragm with spermicide) to effectively prevent pregnancy. It is not known whether lesinurad passes into breast milk and harms a baby. So let your doctor know if you are breast-feeding to get the right advice. Store Zurampic at room temperature, away from moisture and out of direct sunlight. Possible drug interactions, you should tell your doctor about all your current medications and any medications you start or stop using, especially drugs like aspirin; valproic acid; antibiotics or antifungals; drugs to treat high cholesterol; heart or blood pressure medication; hormonal birth control such as the pill, patch, implant, or some IUDs; or other gout medications.
Zurampic is used to help reduce uric acid in the blood that causes gout by increasing elimination. This is a prescription drug and should only be used under the direction of a doctor, avoid self-use.
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