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Antibiotics are a very important and commonly used group of drugs in clinical practice in most infections-related diseases. There are many different groups with different mechanisms of action. In which Cephalosporin is a group of widely used broad-spectrum antibiotics and Zanimex 750 is an injectable antibiotic belonging to this group.
1. What is Zanimex?
Zanimex 750 has the main active ingredient Cefuroxim (in the form of Cefuroxim sodium) 750mg content is prepared in the form of a powder for injection. Cefuroxime is a semi-synthetic broad-spectrum antibiotic, belonging to the Cephalosporin group of antibiotics, Cefuroxime powder for injection is prepared as the sodium salt. Cefuroxime has high antibacterial activity by inhibiting bacterial cell wall synthesis through binding to essential target proteins (penicillin-binding proteins).
The cause of bacterial resistance to Cefuroxime may be due to the bacteria secreting the enzyme cephalosporinase, or by altering the penicillin-binding proteins.
Cefuroxime has effective and very specific antibacterial activity against many common bacterial pathogens, including beta-lactamase/cephalosporinase-producing strains of gram-positive and gram-negative bacteria. Cefuroxime is particularly stable to beta-lactamase enzymes secreted by gram-negative bacteria.
2. Uses of Zanimex 750
Zanimex 750 is indicated for use in the following cases:
Infections caused by sensitive bacteria in the respiratory tract; Genitourinary tract infections; Abdominal infections ; Skin and soft tissue infections; There are types of bacterial infections in obstetrics and gynecology; Meningococcal disease ; Sepsis; Use Zanimex 750 to prevent infection after surgery. Adhere to the use of Zanimex 750 according to the indications, you can refer to the information on the instruction sheet for the use of Zanimex 750 or follow the doctor's prescription.
Contraindication to the use of Zanimex 750 in patients with hypersensitivity to Cephalosporin antibiotics and its components, in patients with hypersensitivity to penicillin group antibiotics, the possibility of cross-allergy with Zanimex should be considered. 750 .
3. Dosage and route of administration of Zanimex 750
Adults: use Zanimex 750 at a dose of 750 mg every 8 hours, administered intravenously> for severe infections, the dose of Zanimex 750 can be increased to 750 mg - 1.5 g every 8 hours, intravenously. The total dose of Zanimex 750 is maintained in the range of 3 - 6 g / day, used for 10 days. Patients with renal failure with ClCr 10-20mL/min: use the drug at a dose of 750mg intravenously every 12 hours; For patients with ClCr < 10 mL/min: 750 mg IM or IV every 24 hours. Children > 3 months old: use Zanimex 750 at a dose of 50-100 mg/kg/day; In case of severe infection, higher dose of Zanimex 750 can be used up to 100 mg/kg/day; Osteoarthritis infections use Zanimex 750 dose 150 mg/kg/day, meningitis dose 200-240 mg/kg/day. Patients need to apply the exact dose of Zanimex 750mg as prescribed by the doctor or can refer to the package, the drug instruction sheet, do not arbitrarily calculate, apply or change the dose.
4. Side effects of Zanimex 750
In general, the side effects caused by the active ingredient Cefuroxime are usually mild and last only a short time. A small number of patients receiving Cefuroxime may experience gastrointestinal disturbances, including: diarrhea, nausea, and vomiting.
Similar to broad-spectrum antibiotics, Zanimex 750 has also been reported (very rarely) of pseudomembranous colitis, vaginitis, headache.
Eosinophilia and transient increases in liver enzymes (ALT and AST) have been observed during treatment with Zanimex 750. In addition, Zanimex 750 can also cause anemia, bleeding or seizures.
5. Be careful when using Zanimex 750
Objects to note before taking Zanimex 750:
Allergy to Penicillin antibiotics; Old people; Pregnant and lactating women; Children < 15 years old; Patients with hepatic and/or renal impairment; Subjects with myasthenia gravis, hepatic coma; The patient has a history of gastrointestinal disease, peptic ulcer disease, colitis.
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