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Voradax is indicated for patients infected with hepatitis C virus. However, Voradax has serious interactions with some drugs. So when using Voradax, what should be noted to be effective and safe?
1. What is Voradax?
Voradax is made in the form of film-coated tablets with the active ingredient Sofosbuvir, content 400 mg.
Sofosbuvir is an inhibitor of HCV NS5B RNA-dependent RNA polymerase (5B non-structural protein). Following intracellular metabolism to the pharmacologically active uridine analog triphosphate (GS-461203), sofosbuvir is incorporated into HCV RNA by NS5B polymerase and induces chain termination.
2. Indications of the drug Voradax
Voradax is used in combination with other antiviral agents in the treatment of patients infected with hepatitis C virus (HCV) genoptypes 1-6 or in the treatment of patients co-infected with HIV and HCV. Depending on the degree of cirrhosis or decompensation, a combination of ribavirin alone or ribavirin and peg-interferon alfa can be used.
3. Contraindications of the drug Voradax
Do not use Voradax in patients with a history of allergy to Sofosbuvir or to any of its ingredients.
Voradax is contraindicated in male patients whose female partner may become pregnant.
4. Dosage and usage of the drug Voradax
Dosage: Voradax is taken orally
Dosage: Adult dosage for control of chronic hepatitis C: 400 mg daily. The recommended dosing intervals are as follows:
Genotype 1 or 4: Voradax, ribavirin and peg-interferon alfa for 12 weeks. Genotype 2: Voradax and ribavirin for 12 weeks. Genotype 3: Voradax and ribavirin for 24 weeks. Hepatocellular carcinoma awaiting liver transplant: Voradax and ribavirin for up to 48 weeks or until liver transplant (whichever occurs first).
Dose for children over 3 years to control chronic hepatitis C :
Weight less than 17 kg: 150 mg/day. Weight 17 to less than 35 kg: 200 mg/day Weight over 35 kg: 400 mg/day The recommended dosing schedule is as follows:
Genotype 2: Voradax (appropriate dose) and ribavirin for 12 weeks. Genotype 3: Voradax (appropriate dose) and ribavirin for 24 weeks. Hepatocellular carcinoma awaiting liver transplant: Voradax (appropriate dose) and ribavirin for up to 48 weeks or until liver transplant (whichever occurs first). Children under 3 years of age: There are no studies on the safety of Voradax in this population.
5. Undesirable effects of the drug Voradax
When using Voradax, patients may experience unwanted effects such as dizziness, pale skin, difficulty breathing, sore throat, hoarseness, difficulty swallowing or breathing, chills, fever, rash, or no blisters, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or legs... When the body shows signs on the patient, it is necessary to contact the doctor. for appropriate instructions.
6. Notes when using Voradax
For patients who have been previously infected with hepatitis B , the disease may progress or get worse during or after treatment with Voradax . Patients should have their liver function checked regularly for several months.
Do not arbitrarily change the dose or duration of medication when using Voradax with other drugs. In this case, consult a doctor or pharmacist.
7. Voradax drug interactions
Voradax may interact with the following drugs:
Amiodarone: Voradax may increase the slowing effect of amiodarone's heart rate. Phenobarbital, Modafinil, Oxcarbazepine, P-glycoprotein/ABCB1 Inducers, Primidone, Rifabutin, Rifapentine, Tipranavir: May decrease sofosbuvir serum concentrations. Antidiabetic agents: Voradax enhances the hypoglycemic effect of antidiabetic agents. Atorvastatin: Voradax may increase serum concentrations of atorvastatin. Lumacaftor and Ivacaftor: These 2 agents may increase serum levels of the P-glycoprotein/ ABCB1 substrate (High risk with inhibitors or inducers). Tacrolimus (Systemic): Voradax may decrease serum concentrations of tacrolimus. Vitamin K antagonists (eg, warfarin): Voradax may reduce the anticoagulant effect of vitamin K antagonists. Voradax, which is useful in the treatment of liver disease. Before using, the patient should carefully read the instructions for use and use the drug as prescribed by a specialist to achieve the best effect in the treatment of the disease.
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