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Ribavirin is a broad-spectrum antiviral with little toxicity. This active ingredient is in Vixbarin 400. So what is Vixbarin 400mg indicated in and what should be noted when using it?
1. What does Vixbarin 400mg do?
What is Vixbarin 400mg? Vixbarin 400mg has the main active ingredient is Ribavirin 400mg. Vixbarin 400mg product is in hard capsule form,Ribavirin in Vixbarin 400mg is an antiviral drug with broad spectrum of action and low toxicity.
In vitro, Ribavirin has been shown to be active against at least 20 viruses with different RNA and DNA structures. In vivo evidence also supports the spectrum of activity of Ribavirin, which includes a wide range of viruses with both RNA and DNA structures. Clinical evaluations have demonstrated the efficacy of Ribavirin when used in a variety of ways and in different formulations (including oral, topical, aerosol, or intravenous) in the treatment of hepatitis viruses A, B or C, measles, chickenpox, Herpes simplex types I and II, Herpes zoster, influenza A and B, respiratory syncytial virus (RSV), and many dengue viruses.
In terms of mechanism of action, Ribavirin in Vixbarin 400mg has a similar structure to guanosine nucleotide (1 out of 4 basic components of RNA). RNA is an integral part of protein synthesis. Ribavirin inhibits messenger RNA, thereby preventing viral replication and stopping viral disease. Notably, Vixbarin 400mg only suppresses viral replication without affecting the function of normal cells. Ribavirin has been shown to have a broad spectrum of antiviral activity both in vitro and in vivo.
A very important property of Ribavirin (possibly the result of a variety of mechanisms of antiviral activity) is the inability of the virus to produce mutants resistant to Vixbarin 400mg. Vixbarin 400mg does not cause any serious harmful effects when taken at the recommended dosage, and Vixbarin 400mg also helps improve liver function in patients with chronic hepatitis C.
2. Indications and contraindications of Vixbarin 400mg
Vixbarin 400mg product is indicated for the following cases:
Treatment of hepatitis A, B, C; Herpes zoster virus infection, herpes simplex; Support to shorten the duration of influenza due to influenza A and V strains; Treatment of some diseases caused by viral infections in children such as measles, mumps, chickenpox or respiratory syncytial virus infection. Contraindication of Vixbarin 400mg:
Patients with severe renal impairment (creatinine clearance less than 30ml/min; Patients with chronic anemia (Hb index less than 10 g/dl); Pregnant patients should not take Vixbarin 400mg; People who are sensitive to Ribavirin and other ingredients in Vixbarin 400mg.
3. Dosage of Vixbarin 400mg
Dosage of Vixbarin 400mg recommended for adults:
Hepatitis A: 800mg/day, equivalent to 2 Vixbarin 400mg tablets, divided into several oral doses for 10-14 days; Hepatitis B and C: 800-1200mg/day, equivalent to 2-3 Vixbarin 400mg tablets, divided into 3-4 times orally for a period of 6 months to 1 year; Herpes zoster/simple infection: 800-1200mg/day, divided into 3-4 times orally for 7-10 days; Prevention of recurrence of genital herpes: 400mg/day, equivalent to 1 Vixbarin 400mg tablet orally once a day for 6 months.
4. Side effects of Vixbarin 400mg
No significant adverse events were reported in chronic hepatitis B patients receiving ribavirin for 24 weeks at doses of 800, 1000 or 1200 mg/day. When the patient continued to be treated with the same dose for an additional 24 hours, no significant adverse events were noted.
However, a side effect of Vixbarin 400mg that has been reported is mild reversible hemolytic anemia. However, anemia associated with treatment with Vixbarin 400mg usually causes no symptoms and can be corrected by monitoring red blood cell counts and periodic blood biochemical tests. Thereby, determining the long-term safety level (with 1 year of treatment) of Vixbarin 400mg high dose.
Other side effects of Vixbarin 400mg were also reported to be mild and completely reversible after discontinuation of treatment such as muscle pain, nausea, fatigue and itching.
There are also patients with increased serum bilirubin levels when taking Ribavirin orally or intravenously.
In addition, some other side effects have also been reported including gastrointestinal and central nervous system disorders. Treatment with Vixbarin 400 mg may increase serum uric acid levels, however, in clinical studies no patients with gout with significant symptoms were observed.
5. Some cautions when taking Vixbarin 400mg
Caution should be exercised when prescribing Vixbarin 400mg treatment in patients with cirrhosis of the liver or with progressive renal failure.
Patients with anemia need to stop treatment with Vixbarin 400mg for 2 weeks, if the level of anemia improves, return to the same dose, otherwise it should be adjusted to reduce 200mg/day.
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