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Vinphatoxin has the main activity Oxytocin, is a drug used in obstetrics, has the effect of causing uterine contractions in both frequency and intensity. The drug is produced in the form of a syringe, with a concentration of 1ml/5UI.
1. What effects does Vinphatoxin have?
Vinphatoxin has the main active ingredient Oxytocin, is a drug used in obstetrics with the following effects:
Induce labor and promote labor, stop bleeding after childbirth or cause abortion. Vinphatoxin causes uterine contractions to varying degrees, increasing the amplitude and frequency of uterine contractions. The effect of making milk easy to flow because Vinphatoxin causes contraction of epithelial muscle cells around the mammary gland. Vinphatoxin causes vasodilation, increasing blood flow to organs in the body. Vinphatoxin also has a weak antidiuretic effect.
2. Indications of the drug Vinphatoxin
Vinphatoxin is indicated for the following cases:
Induced labor, difficult labor: For pregnant women who are about to give birth but if the pregnancy continues until natural childbirth, it will affect both mother and child, it is necessary to use it. oxytocin to induce labor. For example: Pregnancy beyond the due date, pregnancy toxicity, fetal malformations, severe birth defects, intrauterine growth retardation, pregnant women with preeclampsia. Prevention and control of postpartum bleeding and haemorrhage. Causing abortion in case of stillbirth or incomplete abortion.
3. Contraindications of the drug Vinphatoxin
Vinphatoxin is not used in the following cases:
Patients with a history of allergy, hypersensitivity to the components of the drug. The patient cannot have a natural birth due to uterine scarring, due to the size of the fetus being larger than the size of the pelvis, due to the high risk of uterine rupture due to pregnancy. The patient has strong uterine contractions, mechanical obstruction of the fetal tract. Patients with pelvic stenosis.
4. Usage and dosage of Vinphatoxin
Usage: Vinphatoxin is produced in the form of a syringe, usually administered intramuscularly. In addition, it can be administered intravenously or subcutaneously. Indication for which route of injection depends on the patient's condition, ability to absorb and the purpose of drug use.
Dosage:
Here is the reference dose:
Induction of labor: Slow intravenous infusion. Proceed to mix 5UI Vinphatoxin in 500ml of 0.9% sodium chloride solution or mix in Ringer lactate solution or 5% Dextrose solution. Initially infuse at a rate of 0.0005-0.004UI/min, then increase the infusion rate to 0.001-0.002UI/min at 20-minute intervals until uterine contractions, labor. The fetal heart rate and uterine contractions should be continuously monitored during the infusion. When labor has progressed as it should, the Vinphatoxin infusion can be stopped. During cesarean section: Inject 5UI into the uterine muscle. Treatment of bleeding after delivery: 5UI slow intravenous injection, if bleeding is heavy, 5-20UI Vinphatoxin can be mixed in 500ml of 5% glucose solution, infused intravenously at an appropriate rate. Induction of normal abortion: 5 UI slow intravenous injection, or infusion 0.02-0.04 units/min. Prevention of postpartum bleeding: slow intravenous injection of 5UI.
5. Undesirable effects of the drug Vinphatoxin
Using Vinphatoxin can cause side effects as follows:
On pregnant women: Allergy, itching, skin erythema, anaphylaxis, postpartum bleeding, arrhythmia, nausea, vomiting, increased uterine tone , spasms, muscle spasms, or uterine rupture. In children: Bradycardia, arrhythmia, CNS damage or reversible brain damage, low Apgar index.
6. Be careful when using Vinphatoxin
When using Vinphatoxin, it is necessary to note some of the following information:
Only qualified medical professionals with full tools and technical means may use Vinphatoxin. Patients are not allowed to arbitrarily mix and administer drugs at home. Requires assessment of both mother and child before inducing labor with Vinphatoxin. In order to prevent complications, pregnant women must be continuously monitored for uterine contractions, fetal heart rate, blood pressure, etc. during drug use. The uterine contraction effect of Vinphatoxin usually disappears immediately after stopping the drug. Pregnant women: Do not use Vinphatoxin for pregnant patients in the first 6 months, except in cases of spontaneous abortion or causing miscarriage. When it is necessary to take medicine, it is necessary to closely monitor the patient's symptoms and follow the doctor's instructions. Women who are breastfeeding: Limit the use of Vinphatoxin to women who are breastfeeding because the drug can be passed through breast milk to the baby causing unwanted effects. The drug should not be used by people who are driving or operating machinery.
7. Vinphatoxin drug interactions
Vinphatoxin when used in combination with one or more drugs can cause synergistic or antagonistic interactions. Patients should inform their doctor about the medications they are taking to avoid unwanted effects.
Vinphatoxin used concurrently with the anesthetic Cyclopropan can cause hypotension. Combination of Vinphatoxin and Dinoproston increases uterine muscle tone. Vinphatoxin reduces the anesthetic effect of Thiopental. Vinphatoxin when used with Prostaglandin increases the risk of uterine rupture. Vinphatoxin infusion for the purpose of inducing labor and labor requires a prescription by qualified obstetrician-gynecologists and is only performed in large hospitals with adequate medical equipment. To ensure the effectiveness of the drug as well as avoid unwanted risks to the mother and fetus, the patient should strictly follow the instructions of the doctor.
