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Vinphaton drug is often used to treat diseases related to cerebral circulatory disorders. To better understand what is the use of Vinphaton? Side effects as well as effective use, please read the article below.
1. What is Vinphaton?
Vinphaton is prepared in the form of an injection solution. Vinphaton medicine has the active ingredient Vinpocetin. The composition of a tube of Vinphaton 2ml will include:
Vinpocetin content of 10mg; Other excipients such as sodium metabisufit. tartaric acid, NaOH, water for injection have just the right amount. (2ml enough). Pharmacodynamics:
Vinpocetin is a compound with a complex mode of action that favorably affects brain metabolism, blood circulation and blood rheological properties. Vinpocetin has neuroprotective effects, neutralizing the harmful effects of cytotoxic reactions caused by stimulation of amino acids. Vinpocetin inhibits voltage-dependent Na+ and Ca++ channels, NMDA and AMPA receptors. It increases the neuroprotective effect of adenosine. Vinpocetin increases glucose and O2 uptake, increasing their consumption by brain tissue. Vinpocetin improves cerebral hypoxia tolerance; increased transport of glucose - a special source of energy for the brain - across the blood-brain barrier; converting glucose metabolism to a more energetically favorable aerobic cycle; selective inhibitor of the Ca++-calmodulin-dependent cGMP-phosphodiesterase (PDE) enzyme; increased levels of cAMP and cGMP in the brain. Vinpocetin increases ATP concentration and ATP/AMP ratio; increases the brain's circulation of norepinephrine and serotonin; stimulates the noradrenergic system upward; have antioxidant activity; The result of all these effects is that Vinpocetin has a protective effect on the brain. Vinpocetin increases cerebral microcirculation, inhibits platelet aggregation, reduces pathological hyperviscosity; increases erythrocyte deformability and inhibits erythrocyte adenosine uptake; increases O2 transport in tissues by decreasing the affinity for O2 of erythrocytes. Vinpocetin selectively increases cerebral circulation: Vinpocetin increases blood supply to the brain; reduces cerebral vascular resistance without affecting systemic circulatory parameters (blood pressure, cardiac output, pulse, total peripheral resistance); does not have the effect of appropriating the blood of other areas. In addition, while taking the drug Vinpocetin will improve the blood supply to the ischemic area with low blood spread (reversible blood-taking effect) that has been damaged (but not necrotic). Pharmacokinetics:
Kinetics of absorption, distribution, metabolism and elimination of drugs to know how to choose the route of drug delivery (oral, intramuscular, intravenous...); the number of times of taking the drug in a day; Dosage depends on each case (age, disease state, physiological state...).
2. What is the use of Vinphaton?
The effects of Vinphaton are:
Vinpocetin has a good effect on brain metabolism, blood circulation and rheological properties of blood; Vinpocetin increases brain metabolism by increasing the absorption of glucose and oxygen, then increasing the use of these substances in brain tissue; Vinpocetin increases blood supply to the brain, reduces cerebral vascular resistance; Vinpocetin through the mechanism of inhibiting Na and Ca channels increases the neuroprotective effect. Vinphaton is indicated for use in the following cases:
People suffering from symptoms of cerebrovascular disorders such as dizziness, tinnitus, memory impairment, loss of concentration, ..; Patients with retinal capillary disorders, macular degeneration, secondary glaucom,..; Tinnitus, hearing loss,...
3. Side effects of the drug Vinphaton
*Injection route:
Cardiovascular: Abnormal heartbeat (fast or slow, prolonged QT interval); phlebitis, palpitations , hypotension, sleep disturbances, dizziness, headache, asthenia; Gastrointestinal tract: Nausea, heartburn, dry mouth; Immune system: Hypersensitivity reactions of the body. *Oral:
Common: Hyperglycemia, headache, hypertension, digestive disorders; Rare: Thrombocytopenia and leukopenia, anorexia and diabetes, insomnia, sleep and anxiety disorders, dizziness, taste disturbances, stupor, hemiplegia, somnolence, absent-mindedness, optic disc edema, myocardial ischemia, myocardial infarction, cardiac arrhythmia, palpitations, effects on extrasystoles, hypertension, flushing, thrombophlebitis, gastrointestinal disturbance , skin redness, increased sweating, pruritus, urticaria, rash, asthenia, hypertriglyceridemia, eosinophilia, abnormal liver function, ST segment abnormality. Very rare: Anemia, erythrocytosis, leukocytosis, erythrocytosis, decreased thrombin time, hypersensitivity reactions, euphoria, depression, tremor, conjunctival congestion, confusion hearing, arrhythmia, atrial fibrillation, dysphagia, mouth swelling, dermatitis, chest discomfort, hypothermia.
4.Drug interactions
4.1. What drugs can interact with Vinphaton? Concomitant use with beta-blockers such as Cloranolol and Pindolol, with Loperamide, Glibenclamide, Digoxin, Acenocoumarol or with Hydrochlorothiazide did not experience drug interactions. In rare cases, a mild additive hypotensive effect has occurred when Vinpocetin is used with Alpha methyldopa, so blood pressure should be monitored frequently when these drugs are used in combination.
Although clinical data do not indicate an interaction, caution should be exercised when co-administered with CNS depressants, antiarrhythmic agents and anticoagulants.
Incompatible with Heparin when administered parenterally, and not for use in patients taking heparin.
4.2. Vinphaton drug interactions with food and drinks Consider using the same drug with alcohol, tobacco, alcoholic beverages or fermentation. Factors that can change the composition of the drug. See details in the leaflet or consult your doctor or pharmacist for more details.
5. How to use Vinphaton effectively?
How to use:
Use intravenous line. Do not inject intramuscularly or intravenously without dilution. The recommended dose is as follows:
Initial dose of 20mg/24h, diluted in 500ml of 0.9% sodium chloride infusion solution. After that, the usual dose is 30mg/24h. For well-tolerated patients whose condition requires an increase in dose, a gradual increase to a level of 1 mg/kg/24 h may be considered. The dose of the drug depends on many factors, so it is not possible to apply the dose of one person to the other, it is necessary to consult a doctor or professional person before use.
Overdose of Vinphaton:
Unusual symptoms of drug overdose should be reported to the doctor or the person in charge. In case of overdose of Vinphaton, there are symptoms that require emergency care. Family members should bring medical records, all prescriptions / bottles of medicine that have been and are being used so that doctors can quickly diagnose and treat. Missing a dose of Vinphaton:
Usually the medicine can be taken within 1-2 hours compared to the prescribed in the prescription. Unless there is a strict time limit, you can take your medicine a few hours after you realize you have forgotten it. But, if the time is too far from the time you need to drink, you should not take the supplement, which can be dangerous for the body. You need to follow it properly or consult your doctor before making a decision.
6. Be careful when using Vinphaton
Note when taking the drug:
Be careful when using for people with diabetes, it is necessary to regularly monitor and check blood sugar during treatment. Care should be taken when using this drug in pregnant women and women who are breastfeeding. Need to weigh the benefits-risks before use, consult a doctor. Machine operators, train drivers, and people working at height need to pay attention when using drugs to avoid unfortunate accidents.
7. Preservation of Vinphaton
Carefully read the instructions on drug preservation information written on the package and the instruction sheet for using Vinphaton. Check the expiry date of the medicine. When not in use, the drug should be collected and disposed of according to the instructions of the manufacturer or the person in charge of medicine. Conventional drugs are stored at room temperature, avoiding direct sunlight or high temperature, which can convert the ingredients in the drug.
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