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Vincerol 1mg drug has an indirect anticoagulant effect by preventing the synthesis of active forms of clotting factors. To better understand what is the use of Vincerol 1mg? What should be taken care of and noted when taking the drug? The following article will help you understand more details about Vincerol 1mg drug.
1. What is Vincerol 1mg?
Vincerol 1mg is a cardiovascular drug manufactured by Vinh Phuc Pharmaceutical Joint Stock Company (VINPHACO) - VIETNAM. Registration number / phone number: VD-28148-17
Dosage form : Tablets.
Ingredients:
Acenocoumarol 1mg. Sufficient excipients.
2. What are the uses of Vincerol 1mg?
2.1. Uses of Acenocoumarol As a vitamin K antagonist, has indirect anticoagulant effect. Mechanism of action: Inhibits the synthesis of active forms of many clotting factors (factors II, VII, IX, X). After oral administration, the drug reduces prothrombin in the blood within 36-72 hours. When stopping taking the drug, the anticoagulant effect can still last for 2-3 days. 2.2. Indications of the drug Vincerol 1mg Vincerol 1mg drug is usually indicated in cases of heart disease causing thrombosis, thrombosis prevention,... Vincerol 1mg drug is used for the following cases:
Prevention of thromboembolic complications Obstruction due to: + Heart disease causing blockage of blood vessels: Atrial fibrillation, mitral regurgitation, prosthetic valve.
+ Myocardial infarction has complications such as severe left ventricular dysfunction, heart wall clots, left ventricular dysrhythmias causing embolism when receiving Heparin replacement therapy.
Prevention of recurrent myocardial infarction when aspirin cannot be treated. Treatment of deep vein thrombosis and pulmonary embolism. It is also used to prevent recurrence when continuing to replace Heparin. Prevention of venous thrombosis, pulmonary embolism in hip surgery. Prevention of thrombosis in catheters.
3. How to use Vincerol 1mg effectively?
3.1. Usage Take orally. Take the tablet whole with a glass of water. The time of use must also comply with the instructions of the doctor. 3.2. Dosage Depending on the patient's response to treatment, the doctor will prescribe the appropriate dose. Refer to the dose as follows:
Adults : Take 4 tablets / time / day in the evening of the first 2 days. On the 3rd day, conduct a biological test to determine the therapeutic dose, usually from 1-8 tablets / day. The dose adjustment to increase or decrease the dose is usually in increments of 1 tablet.
Children : Experience in using drugs to treat children is limited. Therefore, it is necessary to conduct evaluation and close monitoring before and during drug administration in children. You can refer to the starting dose as follows:
+ Children under 1 month old: It is not recommended to use the drug.
+ Children from 1-12 months old: Take 0.14 mg/kg/day.
+ Children from 12 months to 3 years old: Take 0.08 mg/kg/day.
+ Children from 3-18 years old: Take 0.05 mg/kg/day.
Elderly: The initial dose should be lower than the adult dose. The usual average dose is only 1/2-3/4 of the adult dose.
Continuity of Heparin - therapy: Because Acenocoumarol has a slow anticoagulant effect, it is still necessary to continue maintaining Heparin at a constant dose until INK is within the desired value range for 2 consecutive days. If heparin-induced thrombocytopenia, Acenocoumarol should not be used immediately because it may increase the risk of blood clotting. Vincerol 1mg should only be used after antithrombin drugs have been given.
4. Side effects of Vincerol 1mg
Manifestations of bleeding are the most common complications, can occur throughout the body: central nervous system, extremities, viscera, intra-abdominal, intra-ocular... Sometimes diarrhea occurs diarrhea (may be accompanied by fatty stools), individual joint pain. Rarely: Hair loss; focal skin necrosis, which may be inherited from protein C deficiency or protein S cofactor; allergic skin rash. Very rarely, vasculitis, liver damage.
5. Be careful when using medicine and how to store it
5.1. Use in pregnant women and nursing mothers Pregnant women: According to statistics, about 4% of cases of fetal malformations in pregnant women use this drug in the first 3 months of pregnancy. In the following months, there is still a potential risk of teratogenicity, even miscarriage. Therefore, the use of the drug is contraindicated in women during pregnancy.
Breastfeeding mothers : During the use of the drug, avoid breastfeeding. If you still have to breastfeed, you need to supplement vitamin K for the baby and absolutely follow the doctor's instructions.
5.2. People who drive and operate machinery Do not drive or operate machinery when experiencing side effects.
5.3. Other special notes Instruct the patient to strictly follow the instructions. At the same time, raising awareness of patients, helping them understand the possible risk factors and how to handle when taking the wrong medicine, especially the elderly. The drug should be taken regularly every day at the same time to maintain the concentration of Acenocoumarol in the blood. Monitor your INR periodically and in the same place. For the case of surgical intervention, it is necessary to consider and evaluate each individual case to have an appropriate treatment should adjust or stop taking anticoagulants. To make this decision, it is necessary to take into account the risk of thrombosis and the risk of bleeding for each type of surgery. Use caution and adjust the dose accordingly when administering the drug to patients with hepatic, renal or hypoproteinemia. In the first month of treatment, the risk of bleeding complications is very likely, it is necessary to observe and closely monitor the patient.
6. How to handle missed dose, overdose and storage
Missed dose : Take the missed dose as soon as you remember. However, skip the missed dose if it is almost time for your next dose, take your next dose as scheduled. Never take a double dose as indicated.
Overdose:
+ Symptoms: Bleeding.
+ Treatment: Based on the INR and bleeding signs to have an appropriate treatment plan. In case of accidental overdose and bleeding, immediately go to a medical center for timely treatment.
Storage:
Temperature does not exceed 30 degrees Celsius. Avoid moisture and light. Keep out of sight and reach of children.
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