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Venokern 500mg is a drug of Kern Pharma S.L Company, Spain used in the treatment of acute hemorrhoids and chronic peripheral venous insufficiency. Venokern contains the active ingredients Diosmin and Hesperidin with the total content of these two active ingredients is 500mg.
1. What is Venokern 500mg?
Venokern 500mg is prepared in the form of film-coated tablets with the following ingredients:
Main active ingredients: Diosmin and Hesperidin with respective concentrations of 450mg and 50mg; Excipients: Microcrystalline cellulose, Gelatin, Sodium starch glycolate, Magnesium stearate, Talc, Sodium lauryl sulfate, Opadry orange. So what is Venokern? The ingredients Diosmin and Hesperidin contained in this product are essentially flavonoids that have the effect of stimulating venous tone and protecting the vessel wall. Venokern 500mg drug combines 2 active ingredients together, so it has the ability to prolong the vasoconstrictor effect of noradrenalin on the venous wall. In addition, Venokern 500mg acts on the vascular system returning to the heart by reducing the tone and stagnation of the veins. In the microcirculation, Venokern has the effect of reducing capillary permeability and increasing capillary strength.
In terms of pharmacokinetics, in humans after oral administration of Diosmin marked with Carbon 14, it was shown that:
Venokern 500mg is extensively metabolized in the presence of various phenolic acids in the urine; The drug is mainly excreted in the feces, remaining about 14% of the dose is excreted in the urine; The mean half-life of Venokern 500mg is approximately 11 hours.
2. Indications of Venokern 500mg
Venokern 500mg product is used for the following cases:
Treatment of symptoms related to lymphatic venous insufficiency; Treatment of functional signs associated with acute hemorrhoidal pain. In addition to the above indications, Venokern 500mg product should not be used for local cases or a history of patients with hypersensitivity to Diosmin, Hesperidin or any of the excipients contained in the drug.
3. Dosage of Venokern 500mg
Lymphatic vein insufficiency: The usual recommended dose is 2 tablets taken daily, only 2 times at noon and in the evening; Acute hemorrhoid pain: The recommended dose of Venokern 500mg is 6 tablets / day, for the first 4 days, then 4 tablets / day, for the next 3 days and maintained at a dose of 2 tablets / day; Chronic hemorrhoids: The recommended dose is 2 Venokern 500mg tablets per day.
4. Some notes when using Venokern 500mg
During the use of Venokern 500mg, patients should note:
For the indications for treatment of acute hemorrhoidal pain of Venokern, it is important to differentiate from other acute anal diseases, because This product is not a substitute for specific treatments for other anal diseases. Venokern 500mg is only used for short-term treatment of anal hemorrhoids. If the abnormal signs persist, the patient must undergo rectaloscopy to diagnose, then consider re-evaluating the appropriate use of Venokern 500mg for treatment. Venokern has not had any adverse effects on the ability to drive and use machines. Studies in animals have shown that Venokern is not teratogenic, and to date no adverse effects have been reported in humans. Because there are no data on the ability of Venokern to pass into breast milk, medical professionals advise mothers not to breast-feed while taking Venokern. Symptoms of an overdose with Venokern have not been reported, and therefore no specific treatment for overdose has been reported.
5. Undesirable effects of Venokern 500mg
The following side effects have been reported with Venokern 500mg including skin allergies, gastrointestinal disturbances, headache and flushing sensation. In addition, the active ingredient Diosmin can cause mild and rare side effects such as gastrointestinal disturbances and autonomic disturbances, but in most cases, discontinuation of the drug is not necessary.
Note, patients need to quickly notify the treating doctor of any side effects or any unusual manifestations when taking Venokern 500mg.
6. Drug interactions and how to store Venokern 500mg
Until now, there have been no reports of interactions between Venokern and other drugs. However, to be on the safe side, patients should still inform their doctor about any medications they are taking. Store Venokern below 30°C, protected from light and moisture. Venokern 500mg is a drug of Kern Pharma S.L Company, Spain used in the treatment of acute hemorrhoids and chronic peripheral venous insufficiency. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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