This is an automatically translated article.
Uruso medicine is made in the form of tablets, with the main ingredient being Ursodeoxycholic acid. The drug is used in the treatment of gallstones and to improve liver function.
1. What is Uruso?
Uruso 300mg medicine has the main ingredient is Ursodeoxycholic acid 300mg content. After oral administration, Ursodeoxycholic acid is concentrated and stored in the gallbladder. Ursodeoxycholic acid reduces cholesterol saturation by inhibiting the synthesis and secretion of cholesterol in the liver, inhibiting the reabsorption of cholesterol into the intestine. The cholesterol-lowering effect of the drug allows the gradual dissolution of cholesterol stones.
In addition, Ursodeoxycholic acid also increases bile flow, which effectively improves cholestasis. At the same time, Ursodeoxycholic acid protects hepatocytes from the hepatotoxic effects of water-insoluble bile acids such as deoxycholic acid, lithocholic acid, chenodeoxycholic acid by competitive inhibition of intestinal absorption.
Indications for the use of Uruso:
Treatment of cholesterol-rich gallstones when the gallbladder is still functional; Treatment of diseases in the biliary tract and gallbladder such as cholecystitis , cholangitis caused by decreased bile secretion; Treatment of hypercholesterolemia; Improve liver function in patients with primary biliary cirrhosis, chronic liver disease. Contraindications to the use of Uruso:
Patients who are sensitive to the drug, its ingredients; Patients with complete bile duct obstruction (because the choleretic effect of the drug can aggravate the symptoms of the disease); Patients with rapidly progressing hepatitis; Patients with acute cholecystitis; Patients with calcium stones; Pregnant women, suspected of being pregnant or breastfeeding; People with kidney disease; Children under 12 years old; Patients with acute gastric - duodenal ulcer; Patients with colitis, inflammatory bowel disease (such as Crohn's disease); Patients often have abdominal pain due to hepatobiliary; People with chronic liver disease; Patients with reduced function of gallbladder contraction; Patients with galactose intolerance, glucose-galactose malabsorption or lapp lactase deficiency.
2. Usage and dosage of Uruso
Usage: Orally. Uruso should be taken with food.
Dosage:
Cholesterol-rich gallstones when the gallbladder is still functional: Take a dose of 8-12mg/kg/day before going to bed or divided into 2-3 times/day, the larger dose will be taken at bedtime. The duration of treatment is 6 - 24 months depending on the stone size and composition; Improve liver function in primary biliary cirrhosis: Use dose 10-15mg/kg/day, divided into 2-4 times; Treatment of hyperlipidemia, sequelae due to small bowel resection, dyspepsia due to enteritis: Use dose 50-100mg/time x 3 times/day; Improve liver function, biliary disease, liver disease due to decreased biliary secretion: Dose 200mg/time x 3 times/day. Overdose: When taking an overdose of Uruso, the patient may experience diarrhea. In general, other symptoms of overdose will not occur because the absorption of Ursodeoxycholic acid decreases with increasing dose, the drug is excreted in the feces more. Currently, there is no specific treatment for the disease if the drug is overdosed. In patients with diarrhea, fluid and electrolyte rehydration is recommended.
Missed dose: When forgetting a dose of Uruso, the patient should take it as soon as he remembers. If it is almost time for the next dose, the patient should skip the missed dose and continue with the pre-planned dosing schedule, without the need for a double dose to make up.
3. Uruso side effects
When using Uruso, patients may experience some side effects such as:
Digestion: Diarrhea, nausea, vomiting, abdominal pain, heartburn, constipation, epigastric pain; Hypersensitivity: Itching, rash; Other side effects: General malaise, dizziness, leukopenia, elevated enzymes (ALT, AST, ALP, γ-GT), hyperbilirubinemia. When experiencing side effects of Uruso, patients should notify their doctor or go to the nearest hospital for timely intervention.
4. Be careful when using the drug Uruso
Some notes for patients to remember when using Uruso:
Use Uruso under the close supervision of a doctor; During the first 3 months of treatment with Uruso, patients should be monitored for liver function AST, ALT and γ-GT every 4 weeks, then every 3 months. In addition to determining responders or nonresponders in the treatment of primary biliary cirrhosis, this helps detect liver damage early, especially in patients with advanced primary biliary cirrhosis. When appointing the use of Uruso to dissolve cholesterol stones, the progress of treatment should be assessed and timely detection of gallstone calcification depending on the stone size. General gallbladder imaging should be checked after 6 - 10 months of treatment; Do not use Uruso if the gallbladder is not visible on X-ray or in case of decreased gallbladder spasm, calcified gallstones, frequent colic due to hepatobiliary disease; When Uruso is used to treat advanced primary biliary cirrhosis, in rare cases decompensated cirrhosis has been observed, which is partially reversible upon discontinuation of the drug; If diarrhea occurs while taking Uruso, the dose should be reduced. In case the patient has persistent diarrhea, the drug should be discontinued; Uruso should be used with caution in: patients with severe pancreatic insufficiency, patients with gallstones in the bile ducts (can occur cholestasis due to cholestatic effects), patients with hepatic encephalopathy, cirrhosis of the liver, ascites, need a liver transplant; Uruso should not be administered to pregnant women as fetal toxicity has been reported in test animals; It is not known whether Uruso is excreted in human milk, so caution should be exercised when administering the drug to a nursing woman.
5. Uruso drug interactions
Some drug interactions of Uruso include:
Caution when taking Uruso with tolbutamide hypoglycemic drugs for diabetics because Uruso increases the hypoglycemic effect of tolbutamide; Uruso should not be used in combination with activated charcoal, colestipol, cholestyramine, antacids containing magnesium, aluminum hydroxide/aluminum oxide, etc. The reason is that these drugs bind to Ursodeoxycholic acid in the intestine, thereby reducing absorption. and drug efficacy. In case it is necessary to take one of the above drugs, it should be taken at least 2 hours before or after taking Ursodeoxycholic acid; Drugs that increase bile cholesterol (oral contraceptives containing estrogen) or drugs that lower blood cholesterol such as clofibrate may increase the risk of gallstones, affecting the effectiveness of Ursodeoxycholic acid in treating gallstones. ; Ursodeoxycholic acid may increase intestinal absorption of cyclosporin. In patients being treated with cyclosporin, blood levels of cyclosporin should be checked and adjusted if necessary; In some cases, Ursodeoxycholic acid may reduce the absorption of ciprofloxacin; Ursodeoxycholic acid has the potential to reduce peak plasma concentrations and AUC of calcium channel blockers such as nitrendipine. Interactions that reduce the therapeutic effect of dapsone have also been reported. Patients should strictly follow the doctor's instructions while taking Uruso to ensure the therapeutic effect and avoid some dangerous side effects to health.
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