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Pendo-Ursodiol c 500mg is manufactured and registered by Domesco Medical Import-Export Joint Stock Company, Vietnam. Ursodiol 500mg medicine has the main ingredient ursodiol, which is prescribed by doctors to treat liver and biliary diseases. This is a prescription drug and should only be taken with a doctor's prescription.
1. What is Ursodiol 500mg?
Ursodiol 500mg is a prescription drug, belonging to the group of hepatoprotective, cholestatic and lithotripsy drugs. The main active ingredient of the drug is ursodeoxycholic acid with two dosage forms, 300mg and 500mg.
Dosage form: film-coated tablets, oval, white, white inside.
Packing: bottle of 100 tablets or box of 1 blister, 3 blisters, 10 blisters, 10 tablets each.
Pharmacodynamics:
Ursodiol is a secondary bile acid formed by the action of intestinal bacteria. Meanwhile, primary bile acids are bile acids that are formed in the liver and secreted into the gallbladder. Once in the colon, intestinal bacteria convert primary bile acids to secondary. The role of bile acids is to digest lipids. After oral administration, the drug Ursodiol 500mg balances the components of bile (reduces cholesterol saturation of bile) through the mechanism of inhibiting cholesterol absorption in the intestine, while reducing cholesterol excretion into the bile. These are favorable conditions for the dissolution of cholesterol stones.
In cholestatic liver disease, pendo-Ursodiol c 500mg replaces harmful endogenous bile acids, protects hepatocytes and regulates immunity. For cirrhosis, case reports of treatment with Ursodiol 300 mg have shown an effect on slowing damage of the bile ducts. Treatment with ursodeoxycholic acid in the early stages of cystic fibrosis can be optimal.
Pharmacokinetics:
Absorption: After oral administration, ursodeoxycholic acid is rapidly and completely absorbed. Distribution: 96-98% bound to plasma proteins and retained in the liver, a small amount enters the circulation. Metabolism: In the liver, Ursodiol is bound to glycine or taurine and then into bile. Elimination: The drug is excreted mainly in the feces, to a small extent in breast milk, kidneys and bile.
2. Indications and contraindications to the drug pendo-Ursodiol c 500mg
Pendo-Ursodiol c 500mg is used in the following cases:
Patients with primary cholestatic cirrhosis Dissolve cholesterol stones in the gallbladder (stones not visible on radiographs, less than 15mm in diameter, gallbladder function) normal). For children (6-18 years old): the drug is used to treat hepatobiliary disorders caused by cystic fibrosis. Contraindications:
Absolutely do not use Ursodiol 500mg for people who are allergic to the ingredients of the drug. Patients with acute cholecystitis, biliary tract Obstruction of bile ducts Calcified stones of the gallbladder reduce spasm
3. Dosage and how to use pendo-Ursodiol c 500mg
Pendo-Ursodiol c 500mg is a prescription drug, used only with the permission of a doctor. Patients absolutely do not arbitrarily change the dose and route of medication, do not give the medicine to others to use even if they have the same symptoms as you, because the drug can have adverse effects on the health of others.
How to use: The patient needs to swallow the tablet whole with water, do not chew or crush the tablet.
Dosage:
For adults: 13-16 mg/kg/day. Divide into 2 times, drink in the morning and evening. Treatment should be initiated at 250 mg orally twice daily for the first 2 weeks. Thereafter, increase by 250mg/day weekly until the recommended dose or maximum tolerated dose is reached.
While increasing the dose, if diarrhea occurs, the dose should be adjusted until the diarrhea stops. People who are overweight/obese may need a higher dose, with 20mg/kg/day.
Note: the treatment time can last from 3 months to 2 years depending on the composition and size of cholesterol stones. Patients should have a gallbladder X-ray or ultrasound every 3-9 months to monitor the effectiveness of treatment. After the stone disappears completely on radiographs, treatment should be continued for about 3 months.
For children : There are no adequate data on safety in this population. Therefore, it is necessary to consult a doctor if using it for young children.
What to do when you forget to take a dose? Take another dose as soon as you remember. If it is almost time for your next dose, skip it and take your next dose as scheduled. You must not take a double dose next time to make up for the missed dose.
What to do in case of overdose? In case of an overdose, you may experience diarrhea. Therefore, immediately contact the nearest medical facility for timely treatment, the patient can treat diarrhea symptoms by drinking plenty of water and replacing electrolytes.
4. Side effects of pendo-Ursodiol c 500mg
During treatment with Ursodiol 500mg, patients may experience unwanted effects including: headache, dizziness, stomach pain, nausea, constipation or diarrhea, flu-like symptoms such as flu-like symptoms. sneezing, sore throat, stuffy nose, hair loss, rash, itching....
Contact an emergency center right away if you have symptoms of an allergic reaction such as hives, difficulty breathing, facial swelling, lips, throat.
5. Pendo-Ursodiol c 500mg . drug interactions
Drugs that can interact with Ursodiol include: aluminum carbonate, aluminum hydroxide, magaldrate. Because they combine with bile acids in vitro, they may interfere with the absorption of Ursodiol 500mg. The hormone estrogen and its derivatives increase the excretion of cholesterol in the bile and cholesterol-lowering drugs such as clofibrate should not be taken with Ursodiol 500mg. Ursodiol should not be co-administered with cyclosporin in organ transplant patients.
6. Some notes when using Ursodiol 500mg
For pregnant women: There are no adequate studies on the safety of ursodeoxycholic acid in the fetus. However, animal studies have shown reproductive toxicity during the first trimester of pregnancy. Therefore, Ursodiol 500mg should not be used by pregnant women. For lactating women: very low concentrations of ursodeoxycholic acid have been found in breast milk. For drivers and machine operators: the drug has negligible effect, so it can be used for this person. When using the drug, the patient should always carefully read the information about the uses and unwanted effects. Ursodiol 500mg has a shelf life of 3 years. When the drug shows signs of deformation, color changes, no longer has the label, it should not be used anymore.
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