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Ulsepan 40mg belongs to the group of drugs for the treatment of diseases related to the gastrointestinal tract, often indicated in gastroesophageal reflux disease, gastrointestinal ulcer, gastric ulcer, prevention of ulcers caused by use non-steroidal anti-inflammatory drugs, Zollinger-Ellison syndrome.1. How does Ulsepan 40mg work?
Ulsepan 40mg drug has the main ingredient Pantoprazole which is a proton pump inhibitor with structure and effects similar to Omeprazole. This is a substituent Benzimidazole, Pantoprazole is protonated to the active form in the acid-secreting tubules of the parietal cells, where it inhibits the enzyme H+/K+ATPase also known as the proton pump, the final stage. of gastric acid secretion.
After taking Ulsepan 40mg, the anti-secretory effect of Pantoprazole lasts more than 24 hours and inhibits up to 50% of gastric acid secretion after 2.5 hours of taking the drug in healthy people. Gastric acid secretion returned to normal within 1 week of discontinuing pantoprazole and there was no return of hypersecretion. In addition, pantoprazole can also inhibit Helicobacter pylori in patients with peptic ulcer disease and/or reflux esophagitis infected with this bacterium. The combination of Pantoprazole treatment with antibiotics (Clarithromycin, Amoxicillin) can eradicate H.pylori with ulcer healing and long-term remission.
Ulsepan 40mg medicine is usually indicated in the following cases:
Reflux esophagitis in adults and children over 12 years old. Treatment of H. pylori eradication in combination with appropriate antibiotics in patients with peptic ulcers caused by H. pylori. Peptic ulcer . Zollinger-Ellison syndrome and other diseases that cause increased gastric acid secretion. Ulsepan 40mg is contraindicated in cases of hypersensitivity to any of its ingredients.
2. Dosage of Ulsepan 40mg:
Ulsepan 40mg is usually taken by mouth once a day in the morning, 30-60 minutes before meals. Depending on the subject and the goal of treatment, the dosage of Ulsepan 40mg will be different, specifically as follows:Gastroesophageal reflux disease: Take a dose of 40mg orally once a day for a short time. up to 8 weeks) however an additional 8 weeks may be considered for patients who have not healed after initial treatment. Peptic ulcer: Oral 40mg daily for 2-4 weeks for duodenal ulcer and 4-8 weeks for benign gastric ulcer To eradicate H. pylori, Pantoprazole can be combined with 2 antibiotics in the regimen. Treatment regimen of 3 drugs or 4 drugs in a week: Pantoprazole 40 mg, 2 times daily in combination with Clarithromycin 250mg 2 times a day and Metronidazole 400mg, 2 times a day. Prophylaxis of gastrointestinal ulcers caused by non-steroidal anti-inflammatory drugs: 20mg/day orally. Pathological hyperacidity in Zollinger-Ellison syndrome: 40mg twice daily, maximum 240mg/day. Pediatric use data are not limited, Pantoprazole should not be used in children under 12 years of age.
3. Side effects of Ulsepan 40mg
In some patients when using Ulsepan 40mg, side effects may occur such as:
Lymphatic system disorders. Anaphylactic reactions and anaphylactic shock. Hyperlipidemia, change in body weight. Hyponatremia, hypomagnesaemia. Sleep disturbances, depression, disorientation, hallucinations, confusion. Headache. Visual disturbances/blurred vision. Diarrhea, nausea, abdominal pain and bloating. Liver cell damage, jaundice, hepatocellular failure. Urticaria, edema. Steven-Johnson syndrome, Lyell syndrome, erythema multiforme, photosensitivity. Broken hip, wrist or spine. Joint pain, muscle pain. Interstitial nephritis. Gynecomastia. Weakness, fatigue, irritability.
4. Precautions when using Ulsepan 40mg:
Some general notes when using Ulsepan 40mg include:
Before using Pantoprazole or other PPIs, the possibility of stomach or esophageal cancer must be excluded because the drug can mask symptoms and slow down cancer diagnosis. In patients with severe hepatic impairment, it is necessary to consider reducing the dose of Ulsepan 40mg or taking it every other day, 40mg can be taken every other day. Doses above 40 mg/day have not been studied in patients with hepatic impairment, liver enzymes should be monitored during treatment. If an increase is observed, the drug should be discontinued immediately. No dose adjustment is recommended in patients with renal impairment, but the maximum oral dose should be 40 mg. Bacterial gastrointestinal infections increase the bacteria resident in the gastrointestinal tract in the stomach. Proton pump inhibitors have been associated with very rare cases of subacute cutaneous lupus erythematosus. If damage occurs, especially on sun-exposed areas, and if accompanied by joint pain, the patient should see a physician and consider discontinuing the drug. The article has provided information about the uses, doses and precautions when using Ulsepa 40mg. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Ulsepa 40mg exactly as directed by your doctor.
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