This is an automatically translated article.
Peptic ulcers caused by Helicobacter Pylori infection or gastroesophageal reflux disease are familiar diseases and the treatment is also difficult. One of the most frequently used drug groups is the proton pump inhibitor group with the typical representative of esomeprazole in esomaxcare 40 tablets.
1. What is Esomaxcare?
Esomaxcare 40 tablets are made in the form of enteric coated tablets, the composition includes:
The main active ingredient esomeprazole magnesium dihydrate equivalent to esomeprazole 40mg; Excipients: microcrystalline cellulose, povidone (K30), anhydrous colloidal silica, sodium starch glycolate, magnesium stearate, isopropyl alcohol, white Opadry-OY-S-3892, Eudragit L-30 D-55, triethyl citrate, refined talc . Esomaxcare 40 is one of the drugs in the class of proton pump inhibitors in the gastric mucosa. Esomeprazole is the S-isomer of omeprazole, so esomaxcare is similar to omeprazole in the treatment of peptic ulcer and gastroesophageal reflux disease.
Effects of esomaxcare 40:
Inhibiting effect on gastric acid secretion: Active ingredient Esomeprazole binds to proton pump (also known as H+/K+ - ATPase pump) on gastric parietal cells, thereby inhibiting gastric juice secretion. inhibits the effect of the enzyme system and reduces acid secretion into the gastric lumen. Therefore, the effect of esomaxcare 40 tablet includes inhibition of basic acid secretion and also when the stomach is stimulated by various agents; The effect of supporting the destruction of H.P bacteria (Helicobacter pylori); Prevent formation of gastric mucosal ulcers when using NSAIDs.
Esomaxcare 40 tablet được bào chế ở dạng viên nén bao tan trong ruột
2. Indications of Esomaxcare 40 tablets
2.1. Adults Esomaxcare 40 is indicated in the following cases:
Benign peptic ulcer; Zollinger-Ellison syndrome ; Kill H.P. and prevent the risk of duodenal ulcer recurrence due to H.P. infection; Severe gastroesophageal reflux disease, including erosive esophagitis, ulcerative esophagitis, or esophageal stricture determined endoscopically; Prophylaxis and treatment of peptic ulcers associated with NSAID use. 2.2. Children from 12 years of age and older For children over 12 years old, esomaxcare 40 is indicated as follows:
Treatment of duodenal ulcers caused by Helicobacter pylori bacteria; Gastroesophageal reflux disease (GERD), including erosive reflux esophagitis, prevention of recurrence of cured esophagitis, and symptomatic treatment of gastroesophageal reflux disease; Combined with antibiotics in the treatment regimen of duodenal ulcer caused by H.P.
3. Dosage and how to use Esomaxcare 40 tablets
3.1. How to use Esomaxcare 40 orally, need to swallow the tablet whole with water, do not chew or crush the tablet.
Esomeprazole tablets should be taken at least 1 hour before meals.
The duration of use of proton pump inhibitors, including esomaxcare 40, depends on the safety and effectiveness of the treatment of the disease according to the indications and dosage according to the instructions for use or the treating doctor.
3.2. Dosage of esomaxcare 40 Dosage for adults:
Treatment of peptic ulcers with Helicobacter pylori: Esomeprazole is present in the treatment regimen for H.P. Along with antibiotics, including a 3-drug regimen (in combination with amoxicillin and clarithromycin), patients should take esomeprazole 20mg each time, twice daily for 7 days, or 40mg orally once daily for 10 days. day; Severe gastroesophageal reflux with esophagitis: 20-40mg dose for 4-8 weeks, can continue for another 4-8 weeks if symptoms persist or there is inflammation on endoscopy; Maintenance treatment after esophagitis has healed: Dose of 20mg orally once a day, the duration of use can be extended up to 6 months; Prophylaxis of gastric ulcer in patients at high risk of peptic ulcer but required to use NSAIDs: 20mg daily; Symptomatic gastroesophageal reflux disease without esophagitis: 20mg orally once a day for 4 weeks, can continue for another 4 weeks if symptoms have not completely resolved; Stomach ulcers caused by non-steroidal anti-inflammatory drugs: Oral dose of 20mg once a day for 4 - 8 weeks; Zollinger-Ellison syndrome: Depending on the individual patient and the degree of increased gastric acid secretion, the daily dose adjustment is higher than other cases, it can be taken 1 to 2 times a day. Once symptoms are controlled, surgery to remove the tumor should be prompted. In case the tumor cannot be completely removed, long-term use of esomaxcare 40 is required. Dosage of esomaxcare 40 for children 12 years and older:
Gastroesophageal reflux disease (GERD): erosive esophagitis: 40mg dose, taken once a day for 4 weeks, can be used for an additional 4 weeks if esophagitis that has not completely healed or has persistent symptoms; Prevention of recurrence of healed esophagitis: 20mg dose, taken once a day; Symptomatic treatment of gastroesophageal reflux disease (GERD): Take 20mg, once a day if not associated with esophagitis. If control is not achieved after 4 weeks of medication, further laboratory investigation is needed to confirm the diagnosis. Patients can continue to maintain symptom control at a dose of 20 mg once daily; Treatment of duodenal ulcers caused by Helicobacter pylori: Children from 30-40 kg use a combination of esomeprazole 20mg, amoxicillin 750mg and clarithromycin 7.5mg/kg body weight, orally twice a day for 1 week. For children over 40 kg, use a combination of 20mg esomeprazole, amoxicillin 1g and clarithromycin 500mg, orally twice a day for 1 week. Dosage of esomaxcare 40 for other subjects:
Children from 1 to 11 years old should not use enteric coated tablet dosage form, so it is necessary to refer to other dosage forms of the active ingredient Esomeprazole; Children under 1 year of age have not been studied using esomaxcare 40, so it is not recommended.
Esomaxcare 40 sử dụng qua đường uống
4. Contraindications of esomaxcare 40
History of allergy or hypersensitivity to benzimidazole; Do not combine with the drugs nelfinavir and atazanavir; Hypersensitivity to proton pump inhibitors or to any of the other ingredients contained in esomaxcare 40 tablets.
5. Some notes while using esomaxcare 40
Patients with alarming symptoms of malignancy (including significant weight loss, recurrent vomiting, dysphagia, vomiting or bloody stools) should be excluded prior to treatment with esomaxcare 40, because the drug has can alleviate symptoms and cause delay in diagnosis and treatment of malignancies; There should be a regular monitoring plan for patients treated with esomaxcare 40 for a long time, especially for more than 1 year; Patients treated according to a specific regimen should contact their doctor when the disease symptoms change in character or other unusual manifestations appear; The 3-drug Helicobacter pylori eradication regimen, including esomeprazole, requires attention to drug interactions. Clarithromycin is a strong inhibitor of CYP3A4, therefore contraindications and interactions should be considered in people taking other drugs also metabolized by CYP3A4 such as cisapride; Treatment with proton pump inhibitors may slightly increase the risk of gastrointestinal infections; Esomaxcare 40, like other gastric antacids, may cause decreased absorption of vitamin B12 (cyanocobalamin) when long-term treatment, this issue should be considered if the patient is in a state of reduced storage or has other factors such as vitamin B12 (cyanocobalamin). risk of reduced absorption of vitamin B12; Severe hypomagnesemia has been reported with proton pump inhibitors such as esomaxcare 40 for at least 3 months. Manifestations of severe hypomagnesaemia include fatigue, spasticity, delirium, convulsions, dizziness, and ventricular arrhythmias. Most patients with hypomagnesemia can be effectively treated with magnesium supplementation instead of discontinuing proton pump inhibitors; Proton pump inhibitors such as esomaxcare 40, when taken in high doses over a long period of time (more than 1 year) may slightly increase the risk of hip, wrist and spine fractures, especially in the elderly or with other medical conditions. other fracture risk factors; Co-administration of esomeprazole with atazanavir is not recommended. In case of mandatory use of both drugs, close monitoring is required, especially when increasing the dose of atazanavir to 400 mg in combination with 100 mg of ritonavir and should not exceed 20 mg of esomeprazole.
6. Unwanted effects of esomaxcare 40
In general, esomaxcare 40 tablets are well tolerated even when used for a short time or for a long time.
Some common side effects of esomaxcare, including:
Headache, dizziness, skin rash; Nausea, vomiting, abdominal pain, bloating, dry mouth, diarrhea or constipation. Less common side effects of esomaxcare :
Body fatigue, drowsiness or insomnia, rash, itching; Visual disturbances. Some rare side effects of esomaxcare:
Fever, sweating; Peripheral edema; Sensitivity to light; Allergic reactions, including urticaria, angioedema, bronchospasm, anaphylaxis; Agitation or depression, reversible mental confusion, hallucinations in critically ill patients; Agranulocytosis or decreased white blood cells, thrombocytopenia; Increased liver enzymes, hepatitis, jaundice, impaired liver function; Joint pain, muscle pain; Interstitial nephritis; Bullous rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, dermatitis.
Đau đầu, chóng mặt là tác dụng phụ thường gặp của esomaxcare 40
7. Drug interactions of esomaxcare 40
Because the effect of esomaxcare is to inhibit acid secretion, it leads to an increase in gastric pH and affects the bioavailability of pH-dependent absorbed drugs such as ketoconazole, iron salts, digoxin; Concomitant administration of esomaxcare 40, clarithromycin and amoxicillin may increase blood levels of esomeprazole and 14-hydroxy clarithromycin; Esomeprazole interacts with drugs metabolized by cytochrome P450 enzymes, CYP2C19 enzymes in the liver; The combination of esomeprazole and diazepam resulted in a 45% decrease in clearance of diazepam; Esomaxcare 40 may reduce the absorption of atazanavir, nelfinavir into the blood and thereby reduce their effectiveness in HIV treatment; Combining esomeprazole with clopidogrel or methotrexate reduces the therapeutic effect of these two drugs; Esomeprazole taken with tacrolimus may worsen the degree of hypomagnesemia. Esomaxcare 40 tablets are indicated for the treatment of peptic ulcers caused by Helicobacter Pylori infection or gastroesophageal reflux disease, and many other digestive diseases. To ensure effective treatment and avoid side effects, users should carefully read the instructions and consult a doctor or pharmacist.
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