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Triatec 5 mg drug containing the active ingredient ramipril is indicated in the treatment of patients with clinical signs of congestive heart failure in the first few days after an acute myocardial infarction or using Triatec 5mg for adjuvant treatment. for diuretics with or without cardiac glycosides. However, the drug Triatec 5 mg can cause some unwanted side effects such as arrhythmia, myocardial ischemia... Therefore, before using Triatec 5mg, patients should learn carefully and consult your doctor.
1. Mechanism of action of the drug Triatec 5 mg
Triatec 5 mg drug contains ramipril - a strong and long-lasting inhibitor of angiotensin converting enzyme (ACE). Triatec 5 mg can cause vasodilation, and especially in hypertensive patients, while helping to lower blood pressure. The antihypertensive effect of Triatec 5mg as a single dose may occur within 1 to 2 hours of dosing.
Compound Ramipril after being absorbed into the gastrointestinal tract will be hydrolyzed in the liver and produce ACE inhibitor A. This is a potent and long-acting ACE inhibitor. Ramipril increases plasma renin activity and decreases plasma ACEII and aldosterone concentrations. The beneficial hemodynamic effects of ACE inhibitors will help reduce ACEII causing peripheral vasodilation and decrease vascular resistance.
ACE-converting enzyme is similar to kinase II-enzyme that degrades bradykinin. Studies have shown that ACE inhibition by the active ingredient ramipril may have some effect on the kallikrein kinin-prostaglandin system. These effects contribute to the antihypertensive and metabolic activity of ramipril.
Triatec 5 mg after oral administration is rapidly absorbed from the gastrointestinal tract, and peak plasma concentrations of ramipril can be achieved in about 1 hour. Thereafter, plasma concentrations of ramipril may decrease over several phases. The half-life of Triatec 5mg after administration can be 13 to 17 hours with doses of ramipril content of 5 to 10mg. However, with lower ramipril from 1.25 to 2.5 mg, the duration may be longer. The difference in the half-lives at the two different doses is related to the long terminal phase of the ramipril compound concentration-time curve. This last phase is quite dose independent, so the potential for enzyme saturation to bind ramipilate can be seen.
2. Indications and contraindications to the use of Triatec 5 mg
Triatec 5 mg is indicated for stable treatment patients with clinical signs of congestive heart failure within the first few days after acute myocardial infarction. Furthermore, Triatec 5mg is also indicated in the adjuvant treatment of diuretics with or without cardiac glycosides. Triatec 5 mg is effective to help reduce the risk of myocardial infarction, stroke - the cause of cardiovascular death or the need for coronary revascularization procedures in patients aged over 55 years and both. clinical evidence of coronary artery disease, stroke, or peripheral vascular disease.
However, the drug Triatec 5mg is also contraindicated in some cases such as: allergic to the drug's ingredients, or a history of angioedema, or in case the patient has a narrowing of the renal artery that reduces blood flow. bilateral or unilateral in people at risk of hypotension and renal failure. People with low blood pressure or unstable circulation may be at risk of hypotension and kidney failure. Patients with diabetes or moderate to severe renal impairment should not use the drug. Because the drug has the ability to antagonize the angiotensin AIRAS receptor in patients with diabetes.
3. Dosage and how to use Triatec 5mg
Drugs are treated through a doctor's prescription. For the treatment of hypertension, the recommended starting dose is usually 2.5 mg. It is possible to increase the dose of the drug, but it depends on the response of the individual. The dose may be doubled every 2 to 3 weeks after the first dose. For maintenance use, usually in concentrations from 2.5 to 5 mg and the maximum dose can be up to 10 mg / day
For patients with creatinine clearance in the range of 50 to 20 ml / min, the starting dose is usually 1.25mg and the maximum daily dose should not exceed 5mg.
Patients who have not been completely treated for salt and water dehydration, or who have severe hypertension or who have a hypotensive response are classified as at special risk and should be consider reducing the therapeutic dose to 1.25mg/day.
Patients who have been pre-treated with diuretics should consider and discontinue diuretics for at least 2 to 3 days or longer before starting Triatec 5mg. Or you can reduce the dose of diuretics. And these activities will depend on each specific case to appoint the starting dose in these patients is also usually 1.25mg.
In cases of liver failure, the response to treatment may be increased or decreased, so drug therapy should be treated with a maximum daily dose of 2.5mg.
Treat congestive heart failure with the recommended starting dose of 1.25 mg once daily. The dose may be increased according to individual patient response. The maximum daily dose may be 10mg.
Post-infarction treatment may be recommended using a dose of 5mg daily in divided doses of 2.5mg and should be used in the morning and evening. If the patient cannot tolerate this dose, a dose of 1.25 mg should be taken twice daily.
4. Undesirable side effects of Triatec 5mg
Triatec 5mg medicine can cause some unwanted side effects affecting the systems in the body:
Cardiovascular system and nervous system: a drop in blood pressure, especially when stopping the first dose or Increased dose or due to use with diuretics, patients may experience drug shock. Symptoms include angina pectoris, myocardial infarction, heart palpitations, dizziness, taste disturbances, headache, dizziness, vertigo... Kidney and electrolyte balance with signs such as increased urea serum, impaired renal function can lead to acute renal failure, increased serum potassium... Respiratory tract and anaphylactoid reactions, skin reactions with symptoms such as sinusitis, bronchitis, difficulty breathing, nasal congestion, angioedema, exfoliative dermatitis, urticaria... The gastrointestinal tract can cause symptoms such as fatal pancreatitis, increased pancreatic enzymes, small bowel edema, constipation, dry mouth. .. Hematology with symptoms such as leukocytosis, decreased hemoglobin, platelets... Drug interactions Triatec 5mg: The drug is contraindicated in combination with drugs containing aliskiren not used in patients with aliskiren-containing drugs. patients with diabetes or moderate renal impairment. Or angiotensin II receptor antagonists in patients with diabetic nephropathy. In addition, when combined with antihypertensive drugs or drugs capable of causing hypotension, caution should be exercised and interactions that may potentiate hypotension should be expected.
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