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Trianic-night is a drug commonly used in the treatment of colds, flu,... So what is Trianic-night and how is it used?1. What is Trianic-night?
Trianic-night is a drug that combines many ingredients, the drug is made in the form of film-coated tablets with the main ingredients in each tablet being:Paracetamol 500mg; Dextromethorphan hydrobromide 15mg Paracetamol is the active metabolite of Phenacetin, it has antipyretic and analgesic effects. The drug achieves its effect by inhibiting the biosynthesis of prostaglandins. Paracetamol only has the effect of lowering body temperature when there is a fever, and rarely lowers body temperature in normal people. Because it affects the hypothalamus, it causes hypothermia, vasodilation, and increased blood flow to the periphery. Paracetamol has no anti-inflammatory activity.
Dextromethorphan hydrobromide is a cough suppressant that acts on the cough center in the medulla oblongata. This active ingredient is most effective in the treatment of chronic cough without phlegm. Dextromethorphan hydrobromide is commonly used in combination with other agents in the treatment of upper respiratory tract symptoms. This active ingredient has no expectorant effect.
Dextromethorphan is nearly equivalent in potency to codeine. However, compared with codeine, dextromethorphan is less likely to cause gastrointestinal side effects. At therapeutic doses, the antitussive effect of Dextromethorphan lasts for 5-6 hours. The toxicity of this active substance is low, but if used in very high doses can cause central nervous system depression.
2. Indications and contraindications of the drug Trianic-night
Trianic-night is indicated in the following cases:Pain relief and fever reduction in cases of colds, body aches, cough, runny nose, chills. Treatment of flu symptoms such as: Fever, cough, headache, muscle aches, joint pain, runny nose, stuffy nose, seasonal runny nose, watery eyes, itchy eyes, sinusitis, rash , allergic rhinitis. Trianic-night is contraindicated in the following cases:
Children under 12 years of age. People who are hypersensitive to the ingredients of the drug. Pregnant and lactating women. Severe liver failure Severe cardiovascular disease Myocardial infarction Coronary heart disease. Severe hypertension Atrioventricular block Severe arteriosclerosis. Ventricular tachycardia Severe hyperthyroidism Closed angle glaucoma. Cross-sensitivity to pseudoephedrine Persons experiencing acute asthma attacks. Prostate enlargement Urinary retention pyloric stenosis
3. Dosage and how to use Trianic-night
Trianic-night is used by mouth. Dosage of Trianic-night drug should be according to the doctor's prescription, the reference dose is as follows:Adults and children over 12: Use 1 tablet/time, 2 times a day. Attention when using Trianic-night:
Do not use more than 2 tablets/day. Do not use Trianic-night for many days in a row, unless directed by a doctor. Trianic-night should not be used for more than 48 hours in children 12 to 17 years old, unless directed by a doctor.
4. Trianic-night side effects
4.1. Paracetamol side effects
Common side effects of Paracetamol include:Skin rash and other allergic reactions occasionally occur. Usually erythema or urticaria, these symptoms may be more severe and are accompanied by fever and mucosal lesions. Rare side effects of Paracetamol include:
Nausea, vomiting Anemia Hematopoietic disorders such as pancytopenia, neutropenia, leukopenia. Renal disease, nephrotoxicity with prolonged abuse. Rare side effects of paracetamol: Other hypersensitivity reactions.
4.2. Dextromethorphan hydrobromide side effects
Common side effects include:Fatigue Dizziness Tachycardia Nausea Flushing. Uncommon side effects include: Urticaria.
Rare side effects include:
Skin rash. Gastrointestinal disorders Mild drowsiness. When the drug is used in too high a dose, it can cause odd behaviors due to poisoning, central nervous system depression and respiratory depression. If in the process of using Trianic-night you notice any unusual signs, immediately notify your doctor or go to the nearest medical facility for timely support.
5. Interaction of Trianic-night with other drugs
Interaction of Trianic-night drug related to Paracetamol component:Using Trianic-night drug with Metoclopramide, Domperidone will increase the absorption rate of Paracetamol. Using Trianic-night with Cholestyramine reduces the absorption of Paracetamol. Using Trianic-night with anticoagulants will increase the effect of anticoagulants if paracetamol is used for a long time because of the increased risk of bleeding. Interactions of Trianic-night drugs related to Dextromethorphan HBr:
Drinking alcohol while using Trianic-night will increase the sedative effect of the drug. Using Trianic-night with MAOIs, antidepressants, SSRIs increases the risk of Serotonin syndrome leading to changes in mental status, tremors, tremors, myoclonic tremor, and increased blood pressure. pressure, hyperreflexia, restlessness, sweating. Using Trianic-night with CYP2D6 inhibitors such as Quinidine, Fluoxetin, Methadone, Paroxetin, ... will increase the concentration of Dextromethorphan and increase the side effects of the drug (such as causing insomnia, stimulation of the drug). movement, diarrhea, confusion, tremor, respiratory failure) and development of Serotonin syndrome. Using Trianic-night with Quinidine will increase the concentration of Dextromethorphan in the blood plasma by 20-fold, thereby increasing the side effects of central nervous system disorders of the drug.
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