Uses of Tinizole

This is an automatically translated article.

Tinizol is indicated in the treatment of anaerobic infections of the gastrointestinal tract, gynecology or soft tissue... However, in some cases, when using the drug, it may experience unwanted side effects such as nausea, diarrhea This article will provide more information about the uses and uses of Tinizol.

1. Pharmacokinetics and pharmacodynamics of Tinizol

Tinizol medicine has the ingredient tinidazol 500mg which belongs to the group of drugs that treat parasites or infections or are antiviral or antifungal. An imidazole derivative is similar to the active ingredient metronidazole.
Tinizol drug has effect on protozoa and obligate anaerobic bacteria such as: Clostridium spp, bacteroides spp,... Mechanism of action of Tinidazol compounds with anaerobic bacteria and protozoa. The drug will penetrate the cells of the organism and then destroy the DNA strand or inhibit the synthesis of DNA in the body. Tinidazol has both preventive and efficacious effects in the treatment of infections of the biliary tract or gastrointestinal tract. In addition, Tinidazole is also effective in the treatment of abscesses and treatment of anaerobic infections such as necrotizing fasciitis or gas gangrene. Mixed infections commonly encountered in practice should be treated in combination with Tinidazole and other antibiotics appropriately to eliminate the suspected aerobic bacteria.
During surgery to prevent infection, Tinidazol can be used in combination with gentamicin or cephalosporin before or during surgery. Note that this combination dose should not be used after surgery. Because drugs used in the case of prophylactic use, if prolonged, may not increase the effectiveness of prevention, but also increase the risk of potential infections that can even cause drug resistance.
In case of suspected anaerobic infection, Tinidazol can be used in combination with gentamicin or ampicillin or vancomycin. But in case of suspected gram-negative infection with other anaerobic bacteria, the combination of Tinidazole with 1st or 2nd generation cephalosporins should be used.
If the case is suspected of bacterial infection in mixed anaerobic infections and aerobic, the combination of Tinidazole with a 3rd generation cephalosporin, penicillin and a beta-lactamase inhibitor, monobactam, or gentamicin is recommended. If anaerobic bacteria resistant to the components of Tinidazole are suspected, alternative drugs such as clindamycin or imipenem can be used or a combination of penicillins and beta-lactamase inhibitors can be used.
Ingredients Tinidazol is mostly absorbed after taking into the body. And the maximum concentration of the drug in plasma reached about 40 micrograms / ml after two hours of using a single dose with a concentration of 2 mg. This concentration can be lowered to 10mg/ml after 24 hours and 2.5mg/ml after 48 hours. Using a maintenance dose of 1g per day can maintain concentrations above 8mg/ml. With equivalent concentrations, administered intravenously, Tinidazole also gives serum concentrations similar to oral doses. Tinidazole is widely distributed and is capable of reaching high concentrations in bile, milk, cerebrospinal fluid, saliva or other body tissues. And this concentration is similar to plasma concentration. However, the ingredient Tinidazol is known to readily cross the placenta. Tinizol, either unmetabolized or metabolised, may be excreted in the urine and to a small extent in the faeces.

2. Dosage and how to use Tinizol

2.1. Uses of Tinizol Tinizol is indicated for use in combination with other antibiotics to help prevent infections after surgery caused by anaerobic bacteria, especially infections related to colon surgery. or gastroenterology or gynecology. Tinizol is also effective in the treatment of infections caused by anaerobic bacteria such as: intra-abdominal infections with peritonitis, abscesses or gynecological infections with endometritis or endometritis. endometrial or fallopian tube abscess, sepsis, postoperative wound infection or skin and soft tissue infection or upper and lower respiratory tract infections with pneumonia, purulent pleurisy, pressure lung car. or nonspecific vaginitis or acute gingivitis...
2.2. Dosage For prophylaxis of post-operative infections, Tinizol is used orally in a single dose. Time to take is usually 12 hours before surgery. Treatment of anaerobic infections uses an oral dose for adults on the first day of 2 grams and then 1 gram / time for the next day. or 500mg/2 times a day. This therapeutic dose usually lasts for 5 to 6 days. But the duration of treatment may depend on the results of the clinical examination, especially when thoroughly treating infections in some air sites, the treatment time can last up to 7 days or more. Treatment of non-specific vaginitis will be used indicated for adults with a single dose of 2 grams, and taken once. Treatment for two consecutive days with a total dose of 4 grams can bring about faster healing. Treatment of acute gingivitis with a single dose of 2 grams for adults and a single use Treatment of urinary tract trichomoniasis: Adults use a single oral dose of 2 grams and can be treated with similar doses. this self for your mate. For children using a single dose with a concentration of 50-70mg/kg body weight, this therapeutic dose can be used as a booster dose if necessary. Treatment of giardiasis: Adults use a single oral dose of 2 grams. For children using a single dose with a concentration of 50-70mg/kg body weight, this therapeutic dose can be used as a booster dose if necessary. Treatment of hepatic amoebic infections: Adults use a total dose varying from 4.5 grams to 12 grams depending on bacterial dynamics. In case of liver amoeba infection, it can be combined with purulent withdrawal treated with tinidazole. The initial dose used is 1.5 to 2 grams each time, every day, and this dose is used for 3 days. If treatment for 3 days is not effective, treatment should be continued for up to 6 days. For children, use a dose of 50 to 60 mg/kg body weight and use it for 5 consecutive days. The dose used above is for reference only, so if you are using the drug, you should carefully read the instructions and use it according to the instructions of the treating doctor.
In case of overdose, reactions related to neurological abnormalities or disulfiram-like reactions may occur. Therefore, it is necessary to treat symptoms and support for cases of overdose of Tinizol. Although, most cases of overdose are reactive, they usually resolve on their own, and are not life-threatening. However, using the drug needs to follow the instructions and follow the doctor's instructions to be effective in the treatment of the disease.
If the patient forgets a dose, the missed dose can be used as soon as possible. However, if a dose is missed with the next dose, skip the missed dose and continue with the next dose. Patients should be careful not to double the dose.

3. Side effects when using Tinizol

When using Tinizol, there may be some unwanted side effects including:
Common side effects related to circulation with thrombophlebitis or pain at the injection site or gastrointestinal with other conditions. nausea, loss of appetite, stomach upset, or reactions that change your taste buds immediately. Uncommon side effects may be related to systemic symptoms such as dizziness, headache, vomiting, diarrhea, etc. Rare side effects may include systemic allergy, fever, leukopenia. pharyngitis, stomatitis, rash, arthralgia or peripheral neuropathy. When patients experience symptoms of unwanted side effects caused by the drug, they should stop using the drug and notify the doctor. For emergency cases, it is necessary to take the patient to medical facilities near the place of residence for timely treatment.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.