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Tienam 1g belongs to the group of beta-lactam antibiotics combined with two active ingredients, imipenem and cilastatin, commonly used as an intravenous infusion to treat infections caused by bacteria sensitive to the drug such as respiratory infections. lower, gynecological infections, sepsis.
1. What is Tienam 1g?
What is Tienam 1g drug? Tienam drug 1g has the main ingredients including antibiotics imipenem and cilastatin with the following main uses:Imipenem is a broad-spectrum beta-lactam antibiotic with rapid bactericidal action due to interactions with some penicillin-binding proteins on outer membrane of bacteria. Thereby inhibiting bacterial cell wall synthesis by the same mechanism as other beta-lactam antibiotics. Cilastatin: is a chemical compound that inhibits the human enzyme dehydropeptidase, as it is the enzyme found in the kidney responsible for the degradation of the antibiotic imipenem. Therefore, when combined, cilastatin is responsible for protecting imipenem from dehydropeptidase and prolonging its antibacterial effect. Tienam is usually indicated in the following cases:
Intra-abdominal infections Lower respiratory tract infections Gynecological infections Genitourinary tract infections Skin and soft tissue infections Sepsis endocarditis However, the drug Tienam is also contraindicated in patients who are allergic to imipenem or cilastatin or to any of its ingredients.
2. Dosage of the drug Tienam
Tienam is usually used as an intramuscular injection, not for intravenous use. Dosage of Tienam is calculated according to the amount of imipenem contained in the specific compound as follows:
Skin infections caused by sensitive bacteria, intravenous infusion, adults: 1-2 g/day (divided into 3-4 times) ) Infections caused by susceptible bacteria, adults: 50 mg/kg/day (maximum dose 4 g/day Children over 3 months old: 60 mg/kg/day (maximum dose 2 g/day) divided Do 4 times Children weighing over 40 kg receive the same dose as adults Preoperative prophylactic antibiotics in adults: IV infusion 1000mg at the start of anesthesia and 1000mg 3 hours later. Patients with renal failure take the dose Not more than 2 g/day Patients with renal impairment have a creatinine clearance < 15 ml/min, therefore the antibiotic Tienam should not be used, unless the patient is on hemodialysis within 48 hours.
3. Tienam drug side effects
In some patients when using Tienam, side effects may occur such as:
Phlebitis, vein stiffness Nausea, vomiting, diarrhea Pain at injection site, erythema at injection site Fever, dizziness face, drowsiness, rash, hives, itching Lower blood pressure, convulsions, tachycardia Oral thrush
4. Be careful when using Tienam
Some general notes when using Tienam include:
Serious hypersensitivity reactions can sometimes occur, even lead to death when using Tienam. Therefore, if you have symptoms of an allergic reaction, you should stop taking the medicine immediately. The use of the antibiotic Tienam may increase the risk of convulsions, seizures, and other central nervous system adverse reactions. If focal tremors or myoclonic seizures develop, the patient should be evaluated for neurologic examination, instituted anticonvulsant therapy if not already instituted, discontinued, and the dose reevaluated. Tienam's interaction with valproic acid may increase the risk of convulsions, thereby reducing valproic concentrations below therapeutic doses. Use of Tienam can cause mild diarrhea to fatal colitis. Use Tienam with caution in patients with a history of gastrointestinal disorders Using Tienam may cause partial cross-allergies with other beta-lactam antibiotics Caution when using Tienam in women Pregnancy, lactation and children < 3 months of age Tienam 1g belongs to the group of beta-lactam antibiotics combined with two active ingredients, imipenem and cilastatin, commonly used as an intravenous infusion to treat infections. Infections caused by drug-sensitive bacteria such as lower respiratory tract infections, gynecological infections, sepsis. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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