This is an automatically translated article.
Tiamesolon 16 is a drug known to reduce inflammation and suppress the body's immune system. Therefore, the drug is widely used in the treatment of diseases of the skin, joints and ears, nose and throat. The following article will provide you with basic information about this product, to help you use the drug appropriately.1. What is Tiamesolon 16?
Tiamesolon 16 contains the main ingredient Methylprednisolone 16mg, a glucocorticoid, a 6-alpha-methyl derivative of prednisolone. This ingredient is known for its anti-inflammatory, anti-allergic and immunosuppressive properties.Glucocorticoids inherently inhibit extravasation and permeability of leukocytes into inflamed tissue. From here they will increase the number of neutrophils as well as decrease the number of lymphocytes and especially eosinophils, monocytes in the peripheral blood.
Not only promote good effects on the function of white blood cells, glucocorticoids also have the ability to affect the inflammatory response by reducing prostaglandin synthesis by activating phospholipase A. From here, it will contribute to an increase in the concentration of a phospholipase A. Membrane phospholipids inhibit prostaglandin synthesis. Finally, glucocorticoids will prevent the appearance of cyclooxygenase in inflammatory cells, making an important contribution to reducing the amount of enzymes to produce prostaglandins.
2. Indications and contraindications
2.1. Point
With the above effect, Tiamesolon 16 is indicated for use in the following cases:People who are experiencing abnormal adrenal cortex function. People who are having problems such as atopic dermatitis, respiratory inflammation, arthritis, helping joints or other blood diseases. Patients with rheumatoid arthritis can also use drugs to effectively treat the disease. People with diseases such as bronchial asthma, hemolytic anemia, agranulocytosis, ulcerative colitis, lupus erythematosus. Support the treatment of cancers such as acute leukemia, lymphoma, breast cancer, prostate cancer. Tiamesolon 16 is effective in patients with primary nephrotic syndrome.
2.2. Contraindications
Anyone who is hypersensitive to any of the ingredients should not use this medicine.3. Dosage and usage
Depending on the use of Tiamesolon 16 for adults or children, the dose will have certain differences.Dosage of Tiamesolon 16 for adults:
Use the drug with a starting dose of 4 - 48mg / day, can be used in a single dose or in divided doses depending on the condition of the disease. In case of multiple sclerosis, it can be used at a dose of 160mg/day x 1 week. Then, reduce the dose to 64mg, once every 2 days x 1 month. Rheumatoid arthritis patients use a starting dose of 4-6mg/day, the acute course of treatment is from 16-32mg/day, then gradually decrease. For patients with severe rheumatic disease, use at a dose of 0.8mg/kg/day divided into small doses, then a single daily dose. Patients with acute asthma use with a dose of 32 - 48mg / day, taken for 5 days. When recovering from an acute attack, the dose of Tiamesolon 4 will be reduced rapidly. For patients with chronic ulcerative colitis, severe exacerbations need to take the drug at a dose of 8-24mg/day. Patients with primary nephrotic syndrome use an initial dose of 0.8 - 1.6 mg/kg for 6 weeks, then reduce the dose for 6 - 8 weeks. Patients with immune-induced hemolytic anemia are used at a dose of 64mg/day for 3 days and must be treated for at least 6-8 weeks. Patients with sarcoid disease used at a dose of 0.8mg/kg/day. When the disease is in remission, it can be maintained at a dose of 8mg/day.
4. Side effects
During the use of Tiamesolon 16, patients may have some allergic reactions such as difficulty breathing, swelling of the face or lips, tongue or mouth, rash.Basically, these side effects will go away as soon as you stop taking the medicine. However, in the event of the following serious problems, you should immediately notify your doctor for assistance:
Have vision problems such as decreased vision. There are signs of body swelling, rapid weight gain, a feeling of shortness of breath. Depression, unusual thoughts or behavior. Bloody or tarry stools, coughing up blood. The patient presented with pain in the upper abdomen and spread to the back, nausea and vomiting, and tachycardia. Hypokalemia leads to confusion, irregular heartbeat, increased urination, muscle weakness, or a feeling of limpness in the legs. Malignant hypertension causes headache, tinnitus, blurred vision, chest pain, dyspnea, convulsions. In addition, patients may also experience some rare side effects such as:
Changes in sleep patterns such as insomnia, not sleeping well. On the skin appears many acne, bruises or discoloration, dry, thin skin. Lesions on the skin take a long time to heal, increased sweating. Nausea, abdominal pain, flatulence, headache, dizziness, feeling lightheaded. Change in shape or accumulation of body fat especially in arms, legs, face, neck, chest, waist.
5. Drug interactions
Tiamesolon 16 has the potential to affect the metabolism of drugs such as ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepine, ketoconazole, rifampicin, so it should be used with caution. Phenytoin, phenobarbital, rifampicin and other hypokalemic diuretics may decrease the effectiveness of Tiamesolon 16. Tiamesolon may cause hyperglycemia, so higher insulin doses are needed during treatment with both types. this drug.6. Use caution
Caution should be exercised when using Tiamesolon 16 in patients with osteoporosis, new vascular connections, and mental disorders. Patients with gastric ulcer, duodenal ulcer, diabetes, hypertension, heart failure should also be monitored when taking Tiamesolon. For long-term users, sudden discontinuation of Tiamesolon can cause acute adrenal insufficiency. When using Tiamesolon in high doses, it can affect the effectiveness of vaccines against certain diseases. Care should be taken when administering Tiamesolon to pregnant and lactating women. Above is some information about the drug Tiamesolon 16. Patients need to pay attention to using the right dose to get the best treatment effect.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
