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Tiamcefo is a 3rd generation Cephalosporin antibiotic with a broad spectrum of activity, including many gram-positive and gram-negative bacteria. Tiamcefo is used in the treatment of blood infections, burns caused by sensitive bacteria, subcutaneous abscesses, toxic boils, pneumonia, otitis media.... For more information about Tiamcefo, please visit the website. Readers refer to the article below.
1. What is Tiamcefo?
Tiamcefo is an antibiotic belonging to the 3rd generation Cephalosporin group, containing the main ingredient Cefotiam hydrochloride 1.14g (equivalent to Cefotiam lg) with a concentration of 1g per vial for injection/infusion.
Cefotiam is a bactericidal antibiotic and exhibits bactericidal activity at minimal inhibitory concentrations. The drug has a broad antibacterial spectrum, including both gram-negative and gram-positive bacteria.
The drug is known to be highly active against Haemophilus influenzae, Escherichia coli, Klebsiella sp. and Proteus mirabilis. In addition, the drug is also active against other bacterial strains such as Enterobacter sp., indole-positive Citrobacter Proteus vulgaris, Proteus rettgeri and Proteus morganii.
Tiamcefo has a maximum concentration in the blood 30 - 45 minutes after being administered intravenously. The serum half-life after intravenous administration is 70 minutes.
Elimination: The drug is recovered almost completely unchanged in the urine within 24 hours of administration, largely excreted by the tubules and about 50% by glomerular filtration.
2. What is the use of Tiamcefo?
Tiamcefo is used in the treatment of the following cases:
Blood infections; Subcutaneous abscesses, poisonous boils, boils, nail boils; Infection of a burn or surgical site; Osteomyelitis, arthritis ; Tonsillitis, bronchitis, bronchiectasis accompanied by infection, pneumonia; Lung infection, purulent pleurisy ; Cholangitis, cholecystitis; Peritonitis; Prostatitis, cystitis , urethritis, nephritis - pyelonephritis; Meningitis ; Pelvic inflammatory disease pathology; Intrauterine infection, parametritis, adnexitis, Batholin gland inflammation; Otitis media and sinusitis.
3. Dosage, how to use Tiamcefo
How to use:
Tiamcefo is prepared in powder form for injection / intravenous infusion. How to prepare intravenous solution: Dilute 1g Tiamcefo in 20ml of solvent (eg, distilled water for injection, isotonic sodium chloride solution, glucose injection). Note: Do not use distilled water in the injection phase for drip infusion. Method of drip infusion: Put 5ml of solvent in the vial to dissolve the preparation, continue to dilute with the above solvent for drip infusion. Commonly used solvents are glucose solutions, electrolytes, amino acids and infusions lasting from 30 minutes to 2 hours. For children, the dose is appropriate and prepared as for adults, the infusion lasts from 30 minutes to 1 hour. Dosage:
The drug is used under the doctor's prescription or you can refer to the manufacturer's recommended dose below:
Adults: 0.5 to 2g intravenous Cefotiam hydrochloride (active) per day , divided into 2-4 times/day. Children: intravenous dose of 40-80mg Cefotiam hydrochloride (active)/kg body weight, divided into 3-4 times daily. Patients with renal impairment do not require dose adjustment if the creatinine clearance is equal to or greater than 1 liter/hour (16.6 ml/min). In the case of creatinine clearance less than 1 liter/hour, the dose should be 75% of the adult dose, spaced every 6 or 8 hours. Note: The dose may be adjusted according to the patient's age and symptoms. In adults, the dose of Cefotiam hydrochloride (potency) can be increased to 4 g (potency)/day to treat sepsis. In children this may be increased to 160 mg (active)/kg/day for severe or persistent infections, such as bacteremia and meningitis.
4. Contraindications of Tiamcefo
Absolutely do not use Tiamcefo for patients with a history of allergy to Cephalosporin and Penicillin antibiotics.
5. Undesirable effects when using Tiamcefo
While using Tiamcefo, the following undesirable effects may occur:
Shock: You should stop using the drug and immediately contact the nearest medical facility if the following symptoms appear: fatigue , unusual taste, wheezing, dizziness, ringing in the ears or sweating. Hypersensitivity: You may have symptoms of rash, urticaria, erythema, itching, fever, joint pain when using the drug, notify your doctor immediately for timely help. Skin abnormalities: Stevens-Johnson syndrome or toxic necrosis of the skin may occur, the patient must be monitored carefully. Hematology: Rarely anemia, decreased red blood cells/platelets/granulocytes, eosinophilia. If these unusual symptoms occur, discontinue the drug and initiate appropriate therapy. Liver: Rarely elevated liver enzymes ALT, AST or ALP. Jaundice, increased LDH or gamma GTP... may also occur. Renal: Because severe renal dysfunction may occur, routine testing should be performed and medication discontinued if abnormalities occur. Gastrointestinal system: Severe inflammation of the small intestine with bloody stools such as pseudomembranous colitis may occur. If abdominal pain and diarrhea are frequent, the drug should be discontinued and appropriate therapy instituted. Rarely nausea, loss of appetite. Respiratory system: Because pneumonia, PIE syndrome with fever, cough, shortness of breath, abnormalities in chest X-ray, eosinophilia can occur but rarely, it is necessary to notify the doctor immediately for treatment. timely. Central Nervous System: Overdosage may cause convulsions in patients with renal impairment. Oral mucositis, candidiasis may occur. Vitamin deficiency: Rarely vitamin K deficiency (hypoprothrobinemia, bleeding); vitamin B deficiency (glossitis, stomatitis, anorexia, neuritis).
6. Precautions when using Tiamcefo
Inform the doctor about the history of allergies, medications and other medical conditions. Cefotiam should not be used in patients with a history of hypersensitivity to this drug or to an antibiotic of the Cephem class. The drug is indicated after identifying susceptible strains to avoid antibiotic resistance; The drug should be used for the minimum amount of time needed. You need to be tested for drug reactions on the skin before the injection / intravenous infusion of Tiamcefo. During the period of treatment with this drug, it is advisable to periodically check the function of the liver, kidneys and blood. You should use caution when using the drug if there is a history of hypersensitivity to penicillin antibiotics; personal or family history of predisposition to allergic symptoms such as bronchial asthma, exanthema, urticaria, poor digestion, parenteral nutrition, elderly, debilitated, dysfunctional severe renal function. This medication is for intravenous use only. When administered intravenously in large doses, the drug can cause vasculitis and thrombophlebitis. To prevent the above reactions, care should be taken when choosing the site and method of injection, preparing the solution, and the injection rate should be as slow as possible. Use the medicine immediately after mixing. Use within 8 hours of reconstitution (even if refrigerated). The safety of the drug in neonates and premature infants has not been established, so Tiamcefo should not be used in this population. This medicine may cause false positive in some urine tests, so inform your doctor if you are using this medicine. You need to have your kidney function monitored if taking concomitantly with similar drugs (other antibiotics of the Cephem class) and diuretics such as furosemide, as this combination may increase the risk of kidney disease. There are documented reports of this condition). The drug has not been fully tested for safety in pregnant women, so you should only use Tiamcefo when clearly needed. The drug should be stored in a dry place, protected from light, at a temperature below 30°C. Above is information about uses, dosage and precautions when using Tiamcefo. If the patient has any further questions about the drug, they can directly contact the doctor or pharmacist for timely answers.
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