Uses of the drug Verimed

This is an automatically translated article.

1. What is Verimed?

Verimed contains the active ingredient Mebeverine 135mg. Verimed is classified as a non-cholinergic-resistant smooth muscle antispasmodic.
Verimed is prepared in tablet form, packed in each box of 5 blisters x 10 tablets. This is a product of Medochemie., Ltd and is circulated in Vietnam with the registration number: VN-9663-05.

2. Mechanism of action of the drug Verimed

Mebeverine in Verimed is an antispasmodic active ingredient with selective action on gastrointestinal smooth muscle. Compared with Papaverin, Mebeverine has an antispasmodic effect equal to or 3-5 times more potent.
Structurally, Mebeverine is a derivative of Methoxybenzamide, which has been shown to alter the contractility and motility of the small intestine in patients diagnosed with irritable bowel syndrome. Verimed may also show prokinetic and antispasmodic activity in the small intestine. The active ingredient Mebeverine in Verimed is rapidly and completely absorbed in the duodenal mucosa after oral administration. Verimed is rapidly distributed into body tissues and 76% of an unmetabolized dose is bound to plasma proteins (namely albumin).
Mebeverine is not eliminated but it is completely metabolized. In the first step, the Mebeverine in Verimed is hydrolyzed by the action of esterases to veratric acid and mebeverine alcohol. Mebeverine alcohol is further metabolized to mebeverine glucuronide and mebeverine sulphate. Approximately 8 hours after taking Verimed, 95-98% of the dose is excreted in the urine as metabolites.

3. Indications and contraindications of Verimed

Verimed products are indicated as follows:
Verimed's first indication is to treat irritable bowel syndrome; In addition, Verimed is also used to treat a number of conditions such as chronic colon irritation, constipation caused by spasms, inflammation of the lining of the colon, spasmodic colitis with symptoms of abdominal pain, muscle tension. , persistent diarrhea with or without alternating constipation, bloating; Gastrointestinal spasms secondary to physical disease. Contraindications to the use of Verimed:
Patients who are allergic or hypersensitive to Mebeverine or any of the excipients in the drug Verimed; The patient was diagnosed with paralytic ileus.

4. Dosage, how to use Verimed

How to use Verimed:
This product is produced in tablet form for oral administration; The right time to take Verimed is 20 minutes before a meal; Patients should swallow Verimed tablets whole with water, do not chew or crush the tablets. Recommended dosage of Verimed:
Adults, elderly and children over 10 years old: Take 1 tablet of Verimed each time 20 minutes before meals, 3 times a day. The dose of Verimed can be adjusted gradually after the desired therapeutic effect is achieved (usually after several weeks of treatment).

5. Side effects of the drug Verimed

In general, the active ingredient Mebeverine in Verimed is well tolerated. In very rare cases, some patients may experience some allergic reactions related to Verimed, especially symptoms such as erythema, urticaria and angioedema.
Patients being treated with Verimed need to inform their doctor about any unwanted effects encountered.
Instructions on how to handle side effects of the drug Verimed:
The first thing the patient needs to stop using Verimed; With mild side effects, patients usually only need to stop taking the drug and the abnormal symptoms will be relieved; In case of severe hypersensitivity or allergy, appropriate supportive therapy should be instituted, including keeping the airway open, using epinephrine if hypotension occurs, giving the patient oxygen or administering antihistamines and corticosteroids if indicated.

6. Be careful when using Verimed

Verimed should be used with caution in cases of porphyria.
Experts recommend that antispasmodics, such as Verimed, should not be prescribed for the symptomatic treatment of cystic fibrosis.
The effect of Verimed on the ability to drive and use machines has not been studied, so patients need to be cautious about this and make sure they are able to drive or operate complex machinery. complex.
Animal studies have not revealed any teratogenic effects of Verimed. However, there are no adequate and well-controlled studies in humans, so caution should be exercised when using Verimed during pregnancy.
Mebeverine is not excreted in human milk at therapeutic doses, however, due to lack of clinical data, caution should be exercised when prescribing Verimed to breast-feeding patients
Verimed overdose and management:
theoretically, Mebeverine may cause central nervous system stimulation, especially when taken in excess of the recommended dosage; There is currently no specific antidote for Mebeverine, so cases of Verimed overdose are treated with basic measures such as gastric lavage in combination with supportive and symptomatic treatment.

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