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Flamotax 1 antibiotic with the main ingredient is Cefotaxime indicated in diseases caused by Gram-negative or Gram-positive bacteria such as blood infections, bone and joint infections, pericarditis, meningitis,...1. What is Flamotax 1?
Flamotax 1 has the main ingredient Cefotaxime - a 3rd generation Cephalosporin antibiotic. Cefotaxime has a broad antibacterial spectrum, has a predominant effect on Gram-negative bacteria and is stronger than the 1st and 2nd generation Cephalosporins. For Gram-positive bacteria, Cefotaxime is less effective than 1st generation Cephalosporins.
Bacteria that are usually sensitive to Flamotax 1: Shigella, Salmonella, Enterobacter, Haemophilus influenzae, E.coli, P. mirabilis,.. Currently, the rate of drug resistance of Cefotaxime has been demonstrated in bacterial strains: Staphylococcus, Enterococcus, Xanthomonas hydrophila, Listeria, methicillin-resistant, Pseudomonas cepacia,...
Flamotax 1 is rapidly absorbed after injection, after injection. Since it is widely distributed in body tissues and fluids, about 40% of the drug is bound to plasma proteins. The drug can cross the meninges, to treat bacterial meningitis. The drug is present in the placenta and breast milk after injection.
Flamotax 1 is metabolized mainly in the liver into active substances for use by the body. After injection, most of the drug is excreted in the urine as unchanged drug.
2. Indications of the drug Flamotax 1
Flamotax 1 is indicated for the treatment of the following infectious diseases:
Sepsis; Bacterial infections of bones and joints; Streptococcus endocarditis; Meningitis , brain abscess; Skin infections, soft tissue infections; Gastrointestinal - urinary tract infections; gonorrhea, typhoid; Obstetric and gynecological infections; Lower respiratory tract infections; Prophylaxis of post-operative infections.
3. Contraindications of the drug Flamotax 1
Flamotax 1 should not be used in the following cases.
Allergy to Cefotaxime ingredients, Cephalosporin antibiotics or any of its ingredients; Pregnant and lactating women should not use Flamotax 1 because the drug crosses the placenta and breast milk.
4. Some notes when using Flamotax injection 1
Patients with a history of allergy to penicillin should use caution because of the risk of allergic reactions. The drug is potentially nephrotoxic, and renal function should be checked before and during administration.
5. Interactions with other drugs
Unwanted interactions may occur when using Flamotax 1 with the following drugs:
Colistin increases the risk of kidney damage when used with Flamotax 1. Patients injected with Flamotax 1 may develop focal seizures brain or brain diseases when combined with penicillin. Cyclosporin increases the nephrotoxic potential of Flamotax 1. Probenecid increases the plasma concentration of Flamotax 1 and prolongs the therapeutic effect of the drug. Do not mix the drug with alkaline solution. To prevent cross-reactivity, do not mix antibiotics in the same infusion.
6. Dosage and how to use Flamotax 1
Usage:
The drug is produced in the form of powder for injection. Use distilled water or a suitable solvent for reconstitution, intramuscularly or intravenously. Dosage in adults:
Uncomplicated infections: Intramuscular or intravenous 1g/time. After 12 hours, repeat injection. Severe infections, meningitis: Intravenous or intramuscular injection 2g/time. After 6-8 hours, repeat injection. Uncomplicated gonorrhea: Single intravenous dose of 1g/time. Prophylaxis of infection after surgery: 1g intravenously 30 minutes before surgery. Dosage in children:
Children from 2 months to <12 years: 50-150 mg/kg/day intravenously or intramuscularly x 3-4 times/day. Newborns > 7 days old: 75 - 150 mg/kg/day intravenously x 3 times/day. Premature infants or neonates < 7 days old: 50 mg/kg/day intravenously x 2 times/day. Patients with renal impairment glomerular filtration rate <10mL: dose equal to 1/2 of the usual dose.
7. Flamotax 1 . side effects
Common side effects:
Diarrhea ; At the injection site bruising, thrombophlebitis; Intramuscular injection can cause pain and inflammatory reaction at the injection site; Uncommon:
Decrease in white blood cell lines; Coombs test false positive; Superinfection caused by drug-resistant bacteria; Rare:
Anaphylaxis ; Hemolytic anemia, thrombocytopenia; Increased blood Bilirubin; Pseudomembranous colitis; Thus, Flamotax 1 is a broad-spectrum antibiotic with diverse bactericidal effects. This is an injectable drug that must be used in medical facilities under the direction of a doctor.
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