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Xacimax is a prescription drug used in the treatment of a number of medical conditions such as respiratory tract infections, meningitis and bacteremia,... Follow the article below to know what Xacimax is. And how to use?
1. What is Xacimax?
Xacimax is a combination antibiotic drug, made in the form of tablets. The main ingredients in each Xacimax tablet include:
Amoxicillin (as Amoxicillin trihydrate) 500 mg; Cloxacillin (as Cloxacillin sodium) 250mg. In which:
Amoxicillin is an aminopenicillin group antibiotic, stable in acid environment, with a broader spectrum of activity than benzylpenicillin group antibiotics, especially against gram-negative bacilli. Similar to other penicillins, amoxicillin has a bactericidal effect, due to its ability to inhibit the biosynthesis of mucopeptides of the bacterial cell wall.
Amoxicillin is active against most strains of gram-negative and gram-positive bacteria such as: Streptococcus, non-penicillinase-producing staphylococci, E.coli, H. influenzae, Diplococcus pneumoniae, N.gonorrhaee, and proteus mirabilis.
Amoxicillin is inactive against penicillinase-producing strains, especially methicillin-resistant staphylococcus aureus, all strains of Pseudomonas, most strains of Klebsiella and Enterobacter. Meanwhile, Cloxacillin is an antibiotic belonging to the penicillinase-resistant group of penicillins. Cloxacillin is also a bactericidal antibiotic, thanks to its ability to inhibit bacterial cell wall synthesis like Benzylpenicillin, but with the added resistance of Staphylococcus penicillinase.
Therefore, Cloxacillin is active against penicillinase-producing or non-penicillinase-producing Staphylococcus bacteria with only minimal inhibitory concentrations of about 0.25 - 0.5 mcg/ml.
The combination of these two antibiotics increases the bactericidal effect of Xacimax.
2. Indications and contraindications of Xacimax
Xacimax is indicated in the following cases:
Infections of the respiratory tract and ENT. Genitourinary tract infections. Skin and soft tissue infections. Endocarditis and bacterial meningitis. Bone marrow infection. Brain abscess. Sepsis. Xacimax is contraindicated in the following cases:
People who are sensitive to penicillin and cephalosporin antibiotics. Severe kidney failure. Notes and precautions when using Xacimax
It is necessary to periodically check liver function, when using Xacimax for long-term treatment. Serious hypersensitivity reactions to Xacimax may occur in patients with a history of allergy to penicillin or other allergens. Therefore, it is necessary to ask carefully for a history of allergy to penicillin, cephalosporin and other allergens. If an allergic reaction such as erythema, Quincke's edema, anaphylaxis, Stevens-Johnson syndrome occurs while using Xacimax, it is necessary to stop using the drug and immediately receive emergency treatment with adrenaline, injectable corticosteroid therapy. IV, ventilation, oxygen, including intubation. The patient was never treated with penicillin or cephalosporin antibiotics again. Pregnant women: Only use Xacimax when absolutely necessary. Lactation: Xacimax is excreted in breast milk, so caution should be exercised when using the drug during lactation.
3. Dosage and how to use Xacimax
Xacimax is used orally. Patients should take the drug about 30 minutes before meals or 2 hours after meals.
The dose of Xacimax drug should be according to the doctor's prescription. Reference dose for adults and children from 20kg and over: Use 1 tablet/time, every 8 hours.
Overdose of Xacimax can cause symptoms of nausea, vomiting, epigastric pain, diarrhea, rash. To treat an overdose of Xacimax, it is necessary to use activated charcoal or induce vomiting in the patient. In some cases, if necessary, gastric lavage can be applied.
4. Xacimax drug side effects
Common side effects of Xacimax include:
Outbreak, usually appearing slowly, after about 7 days of treatment. Less common side effects of Xacimax include:
Nausea, vomiting; Diarrhea; Erythema, maculopapular rash and urticaria. Stevens-Johnson syndrome. Rare side effects of Xacimax include:
Excitement, restlessness; Worried; Insomnia ; Confusion; Behavior change; Dizzy; Anemia ; Thrombocytopenia, thrombocytopenic purpura; Eosinophilia; Leukopenia and agranulocytosis. If you experience any side effects of Xacimax medicine, inform your doctor immediately or go to the nearest medical facility for timely treatment.
5. Interaction of Xacimax with other drugs
Using Xacimax with Nifedipine may increase the absorption of Amoxicillin. Therefore, the combination should be avoided. The risk of rash and rash with Xacimax is increased when used concurrently with allopurinol. Xacimax should not be used together with thrombolytics because of the increased risk of major bleeding. Xacimax reduces the effectiveness of oral contraceptives and anticoagulants. Above is all information about Xacimax drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Xacimax medicine at home because there may be unwanted side effects.
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