Uses of the drug Diasante

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1. What is Dimoxiti?

What is the drug Diasante? Diasanté medicine has the main active ingredient is Diacerein with a concentration of 50mg and other excipients in sufficient quantities. This is a pain reliever, antipyretic, non-Steroid anti-inflammatory drug and treatment of bone and joint diseases.
Dimoxiti drug is prepared in the form of white yellow hard capsules, suitable for direct oral use. Packing is a box of 3 pills and each blister contains 10 capsules.
1.1. Pharmacodynamics of the main active ingredient Diacerein According to the results of several in-vitro and in-vivo studies, active ingredients Diacerein and Rhein, its active metabolite, inhibit the production and activity of Diacerein. Interleukin-1. Interleukin-1 is a proinflammatory and pro-catabolic agent, both in the superficial and deep layers of cartilage, in the synovial membrane and in the synovial fluid. At the same time, Interleukin-1 stimulates the production of transforming growth factor (TGF-β) and components of specific extracellular matrix such as proteoglycan, aggrecan, hyaluronic acid and collagen type II. In addition, these substances also have the ability to inhibit the phagocytosis process and the migration of macrophages. In studies in several animal models of osteoarthritis, the active ingredient Diacerein reduced cartilage degeneration compared with the untreated group. Clinical studies have shown significant pain relief and significant improvement in joint function compared with placebo after 1 month of treatment with drugs containing Diacerein. Other studies have also shown that the beneficial effects of Diacerein treatment persist for at least 2 months after treatment with this active ingredient has been discontinued. 1.2. Pharmacokinetics of the active substance Diacerein After oral administration, the active substance Diacerein passes through the liver and is completely deacetylated to rhein. The half-life of rhein averages about 4.5 hours. Approximately 30% of the drug is excreted in the urine from the body. About 80% of rhein is excreted in the urine as sulpho-glucuro conjugates and about 20% as unchanged rhein. After repeated dosing (50 mg twice daily), the active ingredient Diacerein showed a slight potential for accumulation. In subjects with severe renal impairment with creatinine clearance less than 30 ml/min, the AUC and half-life were doubled and urinary excretion was halved.

2. What diseases does Dimoxiti treat?

What disease does Diasante treat? Diasanté drug is used in the treatment of signs and symptoms of osteoarthritis diseases.

3. Usage and dosage of the drug Diasanté

Usage and dosage of the drug Diasanté is as follows:
Diasanté is made in the form of hard capsules, suitable for direct oral use. For adults: Take 2 tablets daily, divided into 2 times, with meals. For patients with renal impairment: Reduce by half the dose for patients with renal impairment with creatinine clearance less than 30 ml/min. It should be noted: the dosage of the drug as the information provided above is for reference only, the patient needs to take the drug according to the instructions of the prescribing and consulting doctor. The reason is that each person will have a different condition and response to medication.

4. Undesirable effects of the drug Dimoxiti

During the use of Diasanté, patients may experience some of the following side effects:
Common undesirable effects when treated with Diasanté are a rapid increase in the time for food to pass through the intestines and abdominal pain. These signs and symptoms may appear during the first few days of treatment, and in most cases, these signs and symptoms will resolve spontaneously with continued treatment. Using Diasanté can make the urine darker yellow. You need to actively inform the treating doctor about the unwanted effects encountered when using Diasanté so that the treating doctor can change and adjust the dosage if necessary.

5. Some notes when using Dimoxiti

In the process of using Diasanté, you need to pay attention to the following points:
5.1. Contraindications of the drug Diasanté Contraindications of the drug Diasanté with the following cases:
People with a history of sensitivity or hypersensitivity to the main active substance or components of the drug. Persons with a history of hypersensitivity to Anthraquinone derivatives. 5.2. Precautions for Dimoxiti Diasanté should not be prescribed to children under 15 years of age. The reason is that there are currently no clinical studies on subjects using the drug in this age group. Diasanté should not be used concurrently with drugs with a laxative effect. Interactions with other drugs, other forms of interaction: The concomitant use of Diasanté should be avoided with drugs containing salts, oxides or hydroxides of aluminum, calcium and magnesium. This is because these drugs reduce the absorption of the active ingredient Diacerein. You can use these substances at a different time, namely more than 2 hours after taking Diasanté. Use in pregnancy and lactation: Diasanté should not be used by pregnant women. In addition, Diasanté should not be prescribed to women who are breastfeeding. This is because it has now been reported that small amounts of diacerein derivatives pass into breast milk. Effects of drugs on driving and operating machines: Currently, there are no specific reports on the harmful effects of Diacerein or Diasanté drugs on the ability to concentrate when driving or operating machines. machinery and equipment. Store the drug Diasanté in a dry place, away from direct light, standard temperature. In addition, you need to keep the medicine out of the reach of children and household pets.
Above is all information about the drug Diasanté, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Diasanté drugs to treat diseases at home, because there may be unwanted side effects on health.
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