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Eucosmin is a non-steroidal anti-inflammatory and rheumatic drug. The drug with the main active ingredient is Diacerein, which is indicated for use in the treatment of osteoarthritis and degenerative joint diseases.
1. What is Eucosmin?
Eucosmin contains the active ingredient Diacerein. Eucosmin is made in the form of hard capsules with a strength of 100mg. In addition, the drug also contains some excipients such as Lactose, croscarmellose sodium, talcum powder, magnesium stearate, just enough for 1 tablet.Pharmacodynamics:
Diacerein is an anti-inflammatory drug, but it does not inhibit prostaglandin synthesis so it does not cause irritation in the stomach. Diacerein and Rhein - active metabolites of Diacerein, inhibit the synthesis of interleukin - 1B (this is a key factor in the pathogenesis of osteoarthritis) and reduce the effect of collagenase (the direct causes degradation of the extracellular matrix), in addition inhibits phagocytosis and macrophage migration. Through the inhibitory effect of interleukin - 1B and cytokines, Diacerein has the effect of reducing the process of osteoarthritis. Pharmacokinetics:
Diacerein is absorbed from the gastrointestinal tract after oral administration. Food can reduce the absorption of Diacerein by about 25%; Following oral administration of 50 mg of Diacerein, peak blood concentrations of 3 mg/l were reached after approximately 2.5 hours. Diacerein is highly bound to plasma proteins, mainly to 99% albumin; Diacerein is metabolized in the liver to the active Rhein. The drug is eliminated mainly in the urine about 80%. The half-life of Diacerein is approximately 7-8 hours.
2. Indications and contraindications to the drug Eucosmin
Indications for use of Eucosmin:
Eucosmin is indicated for use in the treatment of osteoarthritis and degenerative joint diseases. Eucosmin is contraindicated in the following cases:
Allergy or hypersensitivity to Diacerein or any other excipients in the drug, other anthraquinone derivatives. Children under 15 years old. Intestinal disorders such as Crohn's disease, colitis. The patient is suffering from intestinal obstruction or semi-obstruction.
3. How to take Eucosmin
Eucosmin is taken orally, taking the drug away from meals. Reference dose of Eucosmin is as follows:
Adults and children over 15 years old: Take Eucosmin at a dose of 1 tablet/day. Overdose of Eucosmin and its management:
Diarrhea is a possible symptom when taking an overdose of Eucosmin; In case the patient overdoses on Eucosmin, symptomatic treatment is the main thing. If diarrhea persists, notify your doctor for appropriate management. Restore electrolyte balance if necessary. Missing a dose of Eucosmin and what to do:
If you miss a dose of Eucosmin, take it as soon as possible. If it is almost time for the next dose of Eucosmin, skip the missed dose and take the next dose as scheduled. Also, do not take a double dose of Eucosmin.
4. Eucosmin side effects
Using Eucosmin often encounters undesirable effects due to the rapid increase in the time of food passing through the intestines such as diarrhea, abdominal pain. These symptoms may appear within the first few days of treatment and are usually relieved with continued treatment. Also taking Eucosmin might make the urine darker yellow.
In case of serious side effects or unusual symptoms, the patient should stop using Eucosmin and go to the nearest medical facility for timely treatment.
5. Notes when using Eucosmin
Use caution when using Eucosmin in patients with renal failure. In the case of patients with creatinine clearance < 30ml/min, the dose of Eucosmin should be reduced; Pregnant women: Do not use Eucosmin in this subject; Lactation: Small amounts of diacerein derivatives may be excreted in human milk. Eucosmin should not be used by women who are breastfeeding; Ability to drive and use machines: The drug does not affect the ability to drive and use machines.
6. Drug interactions
Avoid concomitant use of Eucomasin with drugs containing salts, oxides or hydroxides of aluminum, calcium and magnesium because these drugs reduce the absorption of Diacerein. These drugs can be used at other times, usually more than 2 hours apart after taking Eucosmin; Eucosmin and laxatives should not be used concurrently; Eucosmin has the main active ingredient, Diacerein, which is indicated for use in the treatment of osteoarthritis and degenerative joint diseases. Diarrhea is the most common side effect of Eucosmin and usually improves with continued treatment. You should consult your doctor before using Eucosmin for safe and effective medication.
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