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Carlozik belongs to the group of antibiotics, antivirals and antifungals and has the main ingredient Azithromycin, which is commonly used to treat lower respiratory tract infections, skin, soft tissue infections or sexually transmitted diseases. So how does the drug Carlozik work?
1. What is the effect of the drug Carlozik?
Carlozik drug has the main ingredient Azithromycin, which is a semi-synthetic antibiotic of the Macrolide family, Azalide subgroup that has a strong bactericidal effect by binding to the Ribosome of pathogenic bacteria, preventing their protein synthesis. Azithromycin has a broad spectrum of antibacterial activity, peak plasma concentrations are reached 2-3 hours after dosing. Azithromycin has good effect on gram-positive bacteria such as Streptococcus, Pneumococcus, Staphylococcus aureus. Some other bacterial strains are also very sensitive to azithromycin such as: Corynebacterium diphtheriae, Clostridium perfringens, Peptostreptococcus and Propionibacterium acnes.
In addition, Azithromycin also has good effects on gram-negative bacteria such as: Haemophilus influenzae, Parainfluenzae and ducreyi, Moraxella catarrhalis, Acinetobacter, Yersinia, Legionella pneumophila, Bordetella pertussis, and parapertussis; Neisseria gonorrhoeae or Campylobacter. In general, Azithromycin is slightly less active against gram-positive bacteria than erythromycin but stronger in some gram-negative bacteria such as Haemophilus. In terms of pharmacokinetics, Azithromycin is rapidly absorbed and oral bioavailability is about 40%. In particular, the drug achieves higher concentrations in cells than in plasma. Therefore, it is good to treat intracellular bacteria. Food reduces drug absorption, oral bioavailability about 40%. The drug is distributed throughout the body, mainly into tissues such as lungs, tonsils, prostate gland, granulocytes and macrophages, ... many times higher in blood. However, the concentration of the drug in the central nervous system is very low. The drug is eliminated mainly in the urine within 72 hours as unchanged drug.
Carlozik is usually indicated in the following cases:
Lower respiratory tract infections: Acute bronchitis and pneumonia; Upper respiratory tract infections: Sinusitis, pharyngitis and tonsillitis, otitis media, pharyngitis; Skin and soft tissue infections; Patients with sexually transmitted infections in both men and women caused by Chlamydia trachomatis or Neisseria gonorrhoeae. The drug Carlozik is contraindicated in patients with hypersensitivity to Azithromycin or the Macrolide group.
2. Dosage of the drug Carlozik
Carlozik is usually taken once a day, 1 hour before a meal or 2 hours after a meal. Depending on the subjects and treatment goals, the dosage of Carlozik will be different, specifically as follows:
Children: 10mg/kg in the first day. Then 5mg/kg/day from day 2 to day 5 or 10mg/kg/day x 3 days. Adults: The first day take a dose of 500mg, the next 4 days take a single dose of 250mg/day
3. Side effects of the drug Carlozik
Azithromycin is a well-tolerated drug, in some patients when using the drug Carlozik may experience side effects such as:
Nausea, vomiting, abdominal pain, vomiting, abdominal distension and diarrhea; Occasionally there is a transient decrease in neutrophils.
4. Precautions when using the drug Carlozik:
Some general notes when using Carlozik include:
When using Carlozik, it is necessary to adjust the dose in patients with renal failure with ClCr < 40 mL/min; Use caution when administering Carlozik to patients with hepatic impairment; Do not take Carlozik with ergot substances; Take Carlozik at least 1 hour before or 2 hours after taking an antacid; Use caution when using Carlozik together with Cyclosporin or Digoxin. Above is all information about the drug Carlozik, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Carlozik is a prescription drug, patients absolutely cannot buy and treat at home because they may experience unwanted side effects.
