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Tendirazol medicine contains the main active ingredient Rabeprazol Na in the form of enteric-soluble microcapsules Rabeprazol sodium pellets 8.5% with a content of 20mg. The drug belongs to the group of drugs that inhibit gastric acid secretion, proton pump inhibitors.1. What is Tendirazol?
Tendirazol medicine contains the main active ingredient Rabeprazol Na in the form of enteric-soluble microcapsules Rabeprazol sodium pellets 8.5% with a content of 20mg. The drug belongs to the group of drugs that inhibit gastric acid secretion, proton pump inhibitors.Tendirazol is made in the form of hard capsules, suitable for direct oral use.
1.1. Pharmacodynamics of the drug Tendirazol Selective proton pump inhibitor; Active ingredient Rabeprazole irreversibly binds to H+/K+ ATPase (prepared from the porcine gastric mucosa) which is an enzyme system present on the cell surface of the gastric parietal cells, thus the active ingredient Rabeprazole inhibits terminal transport with hydrogen ions into the stomach. The reason is that the enzyme system H + / K + ATPase is considered as the acid (proton) pump of the gastric mucosa, so active ingredients Rabeprazole are called proton pump inhibitors. Rabeprazole inhibits gastric acid secretion primarily and when provoked by any irritant.
Thanks to that, the active ingredient Rabeprazole is used in the treatment of peptic ulcer disease and the treatment of pathological hypersecretion of digestive juices (such as Zollinger - Ellison syndrome, multiple endocrine neoplasia, hypertrophy) system cells).
1.2. Pharmacokinetics of Tendirazol Mean bioavailability is about 52%. Metabolism: Tendirazol is metabolised mainly in the liver. Elimination: Tendirazol is eliminated by the kidneys. The mean half-life is about 60-90 minutes. 1.3. Effect of drugs Tendirazol Suppressors of gastric acid secretion: In experiments, the active ingredient Rabeprazole Na inhibited gastric acid secretion stimulated by dibutyl cyclic AMP in the gastric glands of rabbits was isolated. Rabeprazole Na causes strong inhibition of gastric acid secretion stimulated by histamine or Pentagastrin in dogs with chronic gastric fistula. At the same time, the active ingredient also stimulates gastric acid secretion under normal or histamine-stimulated conditions in rats. Reversal of the anti-secretory activity of Rabeprazole Na was faster and the elevation of blood gastrin levels was lower with Rabeprazole Na compared with other Proton pump inhibitors. Anti-ulcer activity: In laboratory experiments with rats, Rabeprazol Na demonstrated potent anti-ulcer activity against a variety of ulcers and ameliorated experimental gastric mucosal lesions (infection-induced stress). cold, stress caused by immersion in water, pyloric ligation, use of cysteine or ethanol - HCI.
2. What disease is Tendirazol used to treat?
Tendirazol is used in the treatment of diseases as follows:Treatment of peptic ulcers; Treatment of gastroesophageal reflux disease (GERD); Treatment of Zollinger-Ellison syndrome.
3. Usage and dosage of Tendirazol
3.1. How to use Tendirazol: Tendirazol is taken orally. Subjects using Tendirazol: Tendirazol can be used for adults.3.2. Dosage of the drug Tendirazol Dosage for treatment of gastroesophageal reflux disease (GERD): use 20mg x 1 time / day for a period of 4 to 8 weeks, can be used for an additional 8 weeks as needed. Dosage for duodenal ulcer treatment: Use 20mg x 1 time / day for 4 weeks. Dosage for treatment of Zollinger - Ellison syndrome: Initial dose is 60mg/time/day, adjust dose according to response. It should be noted: The above drug dosage is for reference only, patients need to take the drug exactly as directed by the doctor or pharmacist to ensure its effectiveness and avoid unwanted side effects.
3.3. In case of forgetting/overdose In case of missed dose: You need to take the initiative to take that dose as soon as you remember. However, when it is too close to your next dose, skip the missed dose and do not take a second dose to make up for the dose you may have missed before. In case of overdose and treatment: If an overdose occurs, it is necessary to notify the treating doctor immediately or if you see any abnormal symptoms, you need to go to the hospital for timely treatment.
4. Undesirable effects of the drug Tendirazol
During the use of the drug, you may experience some side effects of Tendirazol specifically such as weakness, fever, allergic reactions, chills, fatigue, chest pain below the sternum, stiff neck pain, sensitivity. photosensitivity, digestive disorders, dry mouth, belching, rectal bleeding, black stools, anorexia, gallstones, gingivitis, cholecystitis, increased appetite, colitis, esophagitis, glossitis, pancreatitis.You need to actively notify the treating doctor of unwanted side effects when using it for timely and proper handling.
5. Tendirazol drug interactions
Use caution when taking Tendirazol with the following drugs:Digoxin: Digoxin blood levels may increase. Mechanism and risk factors: Digoxin absorption will increase due to increased pH. Phenytoin: It has been reported that a homologous compound (Omeprazole), specifically Tendirazol, prolongs the metabolism and excretion of the active substance Phenytoin. Antacid: Contains Aluminum Hydroxide Gel or Magnesium Hydroxide: It has been reported that the mean serum AUC concentration decreased by 8% after concomitant administration of Rabeprazole - Antacid and 6%. The way to use is to use drugs containing the active ingredient Rabeprazole 1 hour after taking Antacid compared to using the active ingredient Rabeprazole alone.
6. Some notes when using Tendirazol
6.1. Contraindications of the drug Tendirazol Do not use Tendirazol drugs for people with hypersensitivity or sensitivity to the components of the drug or Benzimidazole derivatives.6.2. Note when using Tendirazol In the process of using Tendirazol, patients should note:
It is necessary to exclude the possibility of malignancy when gastric ulcer is suspected. People with liver failure. The person using the drug is a child. Use for pregnant or lactating women: Do not use Tendirazol for pregnant and lactating women. Use for groups of people driving and operating machines: Use Tendirazol with caution when driving and operating machinery. Above is all information about Tendirazol, patients need to carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not buy Tendirazol on your own to treat the disease at home, because there may be unwanted side effects on health.
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