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Allergic rhinitis and chronic idiopathic urticaria are common indications of the new generation of H1 antihistamines containing the active ingredient, Fexofenadine. Among those drugs are prominent drugs such as Telgate 180. So what does Telgate 180 do and how is it indicated?
1. What is Telgate 180?
Telgate 180 film-coated tablets have the active ingredient Fexofenadin hydrochloride 180mg and some excipients with enough content of 1 tablet.
Telgate 180 drug circulated in Vietnam with the registration number VD-24549-16 manufactured by USA - NIC Pharmaceutical Company Limited (USA - NIC Pharma) with the packing specification of each box of 2 blisters x 10 tablets or bottles of 50 tablets and 100 tablets.
2. What does Telgate 180 do?
Fexofenadine in Telgate 180 is an anti-allergic drug based on the new generation H1-receptor antagonist mechanism. The antiallergic effects of Fexofenadine are long lasting and do not cause sedation or drowsiness. Fexofenadine is essentially a metabolite of terfenadine, which has the ability to selectively antagonize the peripheral H1-receptors of histamine. Studies have shown that fexofenadine can inhibit bronchoconstriction upon allergen exposure in susceptible guinea pigs, and has shown an inhibitory effect on histamine secretion from peritoneal mast cells in laboratory rats. In addition, animal studies have not demonstrated anticholinergic or alpha1-adrenergic receptor blocking and CNS effects of fexofenadine.
A study performed in rats on the tissue distribution of marked Fexofenadine showed that Telgate 180 does not cross the blood-brain barrier.
3. Uses of Telgate 180
Telgate 180 is indicated primarily for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria. Accordingly, Telgate 180 drug effectively relieves symptoms such as sneezing, itchy nose, runny nose, itchy eyes, red and watery eyes.At the same time, patients who have a background or history of allergy to Fexofenadine or any other ingredient in Telgate 180 should absolutely not take the drug because it falls into contraindications.
4. Dosage and usage of Fexofenadine
Preparations containing the active ingredient Fexofenadine are for oral use only with the following recommended dosages:
Adults and children 12 years of age and older: Recommended dose 60mg/time, 2 times daily or 180mg (1 dose) tablets Telgate 180 ) taken only once a day; The recommended dose for patients with impaired renal function is a single dose of 60 mg every 24 hours; Elderly patients with impaired liver function do not require dose reduction of Fexofenadine; Patients should take Fexofenadine hydrochloride at least 2 hours from the time of taking gastric antacids containing aluminum or magnesium gels.
5. Telgate 180 . side effects
The frequency of Telgate 180 adverse events, including somnolence, did not depend on the dose used or other factors such as gender, age and race.
Common side effects of Telgate 180 include:
Viral infections such as colds and flu (2.5%); Nausea (1.6%); Dysmenorrhea (1.5%); Drowsiness (1.3%); Indigestion (1.3%); Fatigue (1.3%).
6. Some cautions when taking Telgate 180
Caution should be exercised when using Telgate 180 for pregnant patients and nursing mothers. At the same time, the group of children under 6 years old must be especially careful when using Telgate 180 and it is best to use it only when prescribed by a doctor. To avoid adverse interactions, patients need to use Telgate 180 at least 2 hours before taking stomach antacids containing aluminum and magnesium. Store Telgate 180 at a temperature below 25 degrees Celsius, away from moisture or direct sunlight.
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