Uses of Tasigna 150mg

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1. What is Tasigna 150mg?

Full name: Tasigna 150mg
Ingredients: Nilotinib (as nilotinib hydrochloride monohydrate) – 150mg
Packing: Box of 7 blisters x 4 tablets
Registration number: VN2-240-14
Drug classification: Prescription drugs
Dosage form: Hard capsules
Manufacturer: Novartis Pharma Stein AG; Schaffhauserstrasse, 4332 Stein Switzerland;

2. Uses of Tasigna 150mg

2.1 Indications Indicated for patients with chronic myelogenous leukemia (CML) in case:
Carries Philadelphia chromosome positive chronic stage. Or in the acute phase in patients who are resistant to or intolerant of a previously used therapy. 2.2 Dosage - How to use Dosage:
Usually use nilotinib 200mg without a doctor's prescription, will not use any other drugs. According to different stages, the dose used will also not be the same. Divided into the following stages:
Chronic stage newly diagnosed
Use 300mg/day divided into 2 times. Each dose is about 12 hours apart. Use as long as it is beneficial to the patient's own health. Chronic and accelerated phase
Resistant to or intolerant to at least prior therapy including imatinib. Use 400mg/day, divided into 2 times. Each time is 12 hours apart. Hematologic toxic reactions, but not leukocyte-related, occurred. Increase the therapeutic dose to Tasigna 400mg 1 time / day, in some cases it has to be increased to 2 times / day. When the symptoms begin to improve, the doctor will advise to reduce the dose to 400mg / day, not necessarily 2 times a day. Pay attention to the dosage used in different phases
How to take:
Tasigna is usually taken every 12 hours. Follow the directions on your medicine label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take this medicine on an empty stomach. Do not bring food. Food can increase the level of nilotinib in your blood and possibly increase harmful side effects. Avoid eating anything for at least 2 hours before and 1 hour after you take Tasigna. Take this medication with a full glass of water. Swallow the capsule whole. If you are unable to swallow the capsule whole, you can open the capsule and sprinkle the medicine in with no more than 1 teaspoon of apple cider vinegar. Swallow immediately without chewing. Do not save the mixture for later use. Nilotinib will be taken long term. You should not stop using this medicine unless your doctor tells you to. This medicine may decrease the blood cells that help your body fight infections. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. 2.3 Overdose, missed dose and management Overdose:
Prescription drugs require a prescription from a doctor or pharmacist. Over-the-counter medicines require a leaflet from the manufacturer. Carefully read and follow the exact dose indicated on the prescription or medication leaflet. When taking an overdose of Tasigna 150mg, it is necessary to stop taking it, immediately notify a doctor or pharmacist when there are abnormal symptoms
Overdose management:
Unusual manifestations of overdose need to notify the doctor or the woman. medical responsibility. In case of an overdose of Tasigna 150mg, there are symptoms that need emergency: Call 911 immediately for guidance and help. Family members should bring medical records, all prescriptions/pots of medicine that have been and are being used so that doctors can quickly diagnose and treat
Missed dose and treatment:
Usually drugs can be taken in about 1-2 hours longer than prescribed in the prescription. Unless there is a strict rule about the time of use, the medicine can be taken a few hours after forgetting. However, if the time is too far from the time you need to drink, you should not take it, which can be dangerous for the body. It is necessary to strictly adhere to or consult a doctor before making a decision.

3. Side effects of Tasigna 150mg

Allergic reactions: rash, urticaria, rash. Gastrointestinal side effects: Nausea, vomiting, abdominal pain, diarrhea, constipation, indigestion or upper abdominal pain. Fatigue, weakness, dry skin, hair loss, itching. Headache, dizziness, chest pain, arrhythmia, shortness of breath. Increased sweating, muscle and joint pain, peripheral edema, bone marrow suppression. Hyperbilirubinemia, ALT and AST elevation, hypophosphataemia... Anxiety, nervousness, nervousness, itchy eyes, conjunctivitis,... If you experience the above undesirable effects, stop using the drug. immediately and notify the doctor for timely assistance.

4. Drug interactions

The drug should not be combined with drugs that are strong inhibitors of CYP3A4 or strong inducers of CYP3A4 enzymes (clarithromycin, Ketoconazole, Ritonavir, Voriconazole, Itraconazole, Telithromycin), antiarrhythmic drugs (Disopyramide, Sotalol, Amiodarone, Quinidine) , procainamide). In particular, you absolutely must not take medicine with grapefruit juice.

5. Notes when using Tasigna 150mg

Contraindications
Hypersensitivity to drug components. Not recommended for children, pregnant and lactating women. Low levels of potassium or magnesium in the blood. Long QT syndrome. Note/Precaution
Caution should be exercised when using Tasigna 200mg for patients with cardiovascular problems, blood pressure, patients with severe liver and kidney failure, a history of pancreatitis or patients with total gastrectomy.
For patients with hypokalemia or hypomagnesaemia, dosage adjustment is required. Use with caution in patients lacking galactose tolerant enzymes.
Safety when using the drug with children under 18 years old has not been guaranteed, so you should be very cautious.
Drivers and machine operators should use caution when using the drug because the drug can cause some side effects on vision.
Caution for use on pregnant women and nursing mothers
Pregnant women and lactating mothers should use caution when using the drug, only use it when prescribed by a doctor and when other measures are taken. Other safety not effective.

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