Uses of Synaflox 750

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Synaflox 750mg is an parenteral antibiotic used to treat infections caused by susceptible bacteria in the respiratory tract, urinary tract, genital tract or soft tissue skin. Before using Synaflox 750, patients need to understand the use, strictly follow the indications and instructions of the doctor.

1. Uses of Synaflox 750mg

The main ingredient of Synaflox is Cefuroxime in the form of Cefuroxime sodium 750mg, an antibiotic belonging to the 2nd generation Cephalosporin group with bactericidal effect thanks to its ability to inhibit cell wall formation. The drug has strong activity against gram-positive bacteria, and antibacterial activity on gram-negative bacteria has increased, but it is still inferior to the 3rd generation.
The antibacterial spectrum of Cefuroxime includes pneumococcus, staphylococci, streptococcus groups, belonging to the group of streptococcus. group of gram-positive bacteria and gram-negative strains such as E.coli, Salmonella, Shigella, Haemophilus influenzae. Therefore, Cefuroxime is used in cases of lung infections, urinary tract infections, obstetric and gynecological infections, and infections of the skin and soft tissues.

2. Indications and contraindications of Synaflox 750mg

Synaflox 750mg is indicated in infectious diseases caused by susceptible strains of bacteria:
Respiratory tract infections, ENT infections such as: Community-acquired pneumonia, acute and chronic otitis media, sinusitis, bronchitis laryngitis, pharyngitis, tonsillitis. Urinary tract infections such as cystitis, urethritis, pyelonephritis. Gonorrhea infection, urethritis or gonorrhea cervicitis. Skin and soft tissue infections such as impetigo, boils, pustules. Contraindications of the drug Synaflox 750mg: The drug Synaflox 750mg should not be used with patients:
There is a history of hypersensitivity to drugs of the Cephalosporin group of drugs. People who are allergic to penicillin. People with hereditary disorders of porphyrin metabolism. Children under 3 months old

3. Dosage and how to use Synaflox 750mg

How to use: Synaflox drug is used by intramuscular or intravenous injection. Patients are directly manipulated and supervised by medical staff during treatment. After the injection, the patient needs to follow bed rest and monitor the reaction. If there are any abnormal signs, the patient or family member should immediately notify the medical staff for treatment.
Dosage:
Adults: Usual dose: 750mg every 8 hours, intramuscularly or intravenously. Severe infections: 750mg - 1.5g every 8 hours, intravenously. The total dose used is from 3 to 6g/day. The average duration of treatment is 7-14 days. For patients with renal impairment, adjust the dose according to the glomerular filtration rate (ClCr) ClCr from 10 to 20 mL/min: 750 mg every 12 hours intravenously. ClCr < 10 mL/min: 750 mg every 24 hours, intramuscularly or intravenously. Children 3 months and older: Usual dose: 50-100mg/kg/day. In severe infections, the dose may be increased to 100 mg/kg/day. In case of bone and joint infections: 150mg/kg/day. In case of meningitis: 200-240mg/kg/day.

4. Synaflox 750mg . side effects

Before prescribing Synaflox 750, physicians weigh the benefits against the risks of side effects for each patient. However, some patients may experience unwanted side effects.
Usually, the side effects of Cefuroxime are mild and manifest for a short time. Some common symptoms such as: Diarrhea, nausea, vomiting, abdominal pain, digestive disorders. As with other broad-spectrum antibiotics, long-term use of Cefuroxime can cause pseudomembranous colitis. In addition, headache, vaginitis, and anemia have also been reported.
About the side effects that cause disturbances on the test are often noted symptoms of eosinophilia, increased liver enzymes such as ALT (SGPT) and AST (SGOT) are reversible. In addition, Cefuroxime also causes a positive Coombs reaction which may interfere with blood cross-sectional tests.
Patients who experience the above symptoms while using Synaflox should notify their doctor.

5. Synaflox 750mg . drug interactions

Synaflox may interact if used concurrently with the following drugs:
H2 blockers or antacids. Strong diuretics such as Furosemide, Hydrochlorthiazide, Spironolactone,... Aminoglycoside antibiotics. Probenecid.

6. Treatment of overdose Synaflox 750mg

Cefuroxime overdose usually causes only diarrhea, vomiting, nausea. However, convulsions, neuromuscular excitability, or renal failure may occur. In the management of Synaflox overdose, it is important to provide supportive and symptomatic treatment such as respiratory protection, ventilatory support if necessary, and fluid resuscitation if shock occurs. In case of convulsions, the drug should be discontinued and an anticonvulsant drug such as Diazepam should be used. Hemodialysis may be used to help reduce the amount of medication absorbed into the bloodstream.

7. Notes when using Synaflox 750mg

Caution should be exercised in patients sensitive to penicillin because of the potential for cross-reactivity. Pay special attention to people with a history of anaphylaxis to penicillins. Long-term use of Cefuroxime may promote the growth of non-susceptible strains of bacteria and microorganisms such as Candida, Clostridium difficile or Enterococci. Pseudomembranous colitis should be considered if high-dose or long-term use of Synaflox, especially in the presence of persistent diarrhea. Caution should be exercised when administering Synaflox 750mg to patients with renal impairment. Renal function should be checked and dose adjusted according to creatinine clearance during use. Currently, there are no adequate clinical studies and reports on the effects of Cefuroxime on the fetus or nursing infant. However, with any drug, if you want to use it for pregnant or breastfeeding women, you must be very careful. Because Synaflox 750 may cause dizziness affecting the ability to use machines or drive. Above is the complete information about the drug Synaflox 750mg. Synaflox is a prescription medication and should only be used in a healthcare setting under the supervision of a nurse. Patients need to strictly follow the instructions and note the side effects to notify the doctor in necessary cases.