Uses of Supevastin 10mg

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Supevastin 10mg is a medicine containing the active ingredient Simvastatin with the effect of bringing the patient's blood lipids to normal. The following article will provide you with some information about this drug.

1. What is Supevastin 10mg?

Supevastin 10mg is a drug containing the main ingredient Simvastatin, a lipid-lowering drug that selectively inhibits cholesterol absorption and inhibits endogenous cholesterol synthesis.
Plasma cholesterol is generated from intestinal absorption and endogenous synthesis. After oral administration of Simvastatin, the drug is hydrolyzed in the liver to β-hydroxyacid in the corresponding active form and has a strong effect on the inhibition of HMG-CoA reductase (3 hydroxy-3 methylglutaryl CoA reductase). This yeast acts as a catalyst to convert HMG-CoA to mevalonate. This is the first step to rate-limiting cholesterol biosynthesis.
Simvastatin has been shown to reduce LDL-C levels at normal and elevated levels. LDL-C is formed from very low molecular weight (VLDL) proteins and is catabolized primarily by the high-affinity LDL receptor. Simvastatin lowers VLDL cholesterol (VLDL-C) levels by stimulating LDL receptors leading to decreased production and increased catabolism of LDL-C. In addition, Apolipoprotein B was also significantly reduced during treatment with simvastatin. In addition, simvastatin may moderately increase HDL-C with a decrease in plasma TG. The result of these changes is a decrease in the HDL-C total cholesterol ratio and the LDL-C/HDL-C ratio.

2. Indications of Supevastin 10mg

Supevastin 10mg is indicated in cases of primary hypercholesterolemia and as adjunctive therapy with diet to reduce the elevation of components such as total cholesterol (C-total), apolipoprotein B (Apo B), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary hypercholesterolemia or mixed hyperlipidemia.

3. Instructions for using Supevastin 10mg

Supevastin is intended for use in adults only. During the period before and while taking the drug, the patient should follow a cholesterol diet. Dosage is usually patient-specific through baseline LDL-C levels, treatment goals, and patient response.
The drug is taken orally and is taken only once in the evening, with or without food.
The starting dose should be used from 1 tablet (10/10mg)/day to 10/80mg/day, then can be adjusted according to the individual patient. It is necessary to adhere to a gap of at least 4 weeks to adjust and increase to a maximum of 10/80mg/day. The dose of 10/80 mg should only be used in patients at risk of cardiovascular complications.

4. Contraindications to the use of Supevastin 10mg

The use of the drug is contraindicated in the following cases:
Patients with a history of hypersensitivity to any component of the drug. Patients with active liver disease or those with unexplained persistent elevation of plasma transaminases. Women who are pregnant and breastfeeding. Use with drugs that are strong inhibitors of CYP3A4 such as itraconazole, posaconazole, ketoconazole, HIV protease inhibitors, boceprevir, clarithromycin, telaprevir, erythromycin, telithromycin and nefazodone. People with myopathy secondary to taking other lipid-lowering drugs.

5. Interaction between Supevastin and other drugs

Caution should be exercised when Supevastin is co-administered with the following drugs:
The risk of myopathy or rhabdomyolysis is increased with concomitant use of amiodarone. In the case of patients taking amlodipine, the dose should not exceed 10/20 mg/day. In addition, myopathy/rhabdomyolysis may be increased when used in combination with verapamil, amlodipine, diltiazem. Musculoskeletal disorders may be slightly increased with concomitant use of fusidic acid. Myopathy and rhabdomyolysis may occur when colchicine is used in combination in patients with renal impairment. Therefore, close clinical monitoring is required in patients receiving the combination. Reference source: thuocbietduoc.com.

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