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Pitavastatin is used to treat primary hyperlipidemia or mixed dyslipidemia and atherosclerotic cardiovascular disease. So what is the use of Pitavastatin 2mg and how to use this medicine?
1. What is Pitavastatin 2mg?
Pitavastatin 2mg drug with the main active ingredient is Pitavastatin which is a lipid-lowering drug, an HMG-CoA reductase inhibitor (statin group). Pitavastatin works to reduce the amount of cholesterol made by the liver. Pitavastatin is often used with a healthy diet to lower cholesterol and "bad" fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. This helps reduce the risk of heart disease, and prevents strokes and heart attacks.
Pitavastatin is indicated in the following cases:
As an aid in reducing total cholesterol, LDL cholesterol, apolipoprotein B (Apo B), triglycerides and to increase HDL-C in patients with primary hyperlipidemia or dyslipidemia mixture. Prevention of primary/secondary atherosclerotic cardiovascular disease. Pitavastatin is contraindicated in the following cases:
People with hypersensitivity to pitavastatin or to any of its ingredients. Patients with active liver disease including unexplained persistent elevations in liver transaminases. People who are using cyclosporin. Pregnant and lactating women.
2. Dosage and usage of Pitavastatin 2mg
You should follow a lipid-lowering diet before starting treatment with Pitavastatin and should maintain this diet for the duration of treatment with the drug.
Pitavastatin is to be taken orally once daily, independent of food.
Dosage of Pitavastatin for adults is as follows:
Prevention of cardiovascular events using a dose of 2 - 4 mg x 1 time / day. Treatment of primary hyperlipidemia or mixed dyslipidemia using an initial dose of 2 mg once daily. The maintenance dose is usually 1–4 mg once daily. For patients with moderate to severe renal impairment (GFR 15–59 mL/min/1.73 m2, not on hemodialysis) the initial dose of Pitavastatin is 1 mg once daily, up to a maximum dose of 2 mg x 1 time/day. For patients with end-stage renal disease on hemodialysis, the starting dose of Pitavastatin is 1 mg once daily, up to a maximum dose of 2 mg once daily. The symptoms of Pitavastatin overdose reported were: Severe abdominal pain, vomiting, diarrhea, pain and muscle weakness. There is no specific treatment for Pitavastatin overdose. Patients should be treated symptomatically and supportive measures taken as required. Due to the high protein binding of Pitavastatin, hemodialysis is not beneficial.
If you forget to take a dose of Pitavastatin, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as usual, do not take a double dose.
3. Pitavastatin side effects
Common side effects of Pitavastatin include:
Abdominal pain Constipation Diarrhea Muscle pain Extremity pain. Side effects of Pitavastatin with unknown frequency include:
Asthenia, fatigue, irritability, dizziness. Hepatitis, jaundice, and liver failure can be fatal. Immune-mediated necrotizing myopathy has been associated with statin use. Increased HbA1c, fasting blood glucose levels. Muscle spasms, myopathy, rhabdomyolysis, hypoesthesia, peripheral neuropathy. Insomnia, depression, cognitive decline. Erectile dysfunction Interstitial lung disease. Hypersensitivity reactions to Pitavastatin include rash, pruritus and urticaria.
4. Pitavastatin interactions with other drugs
Pitavastatin in combination with Cyclosporin will increase the risk of myopathy and rhabdomyolysis. Therefore, there are contraindications to the combination. The use of Pitavastatin with Gemfibrozil increases the risk of myopathy and rhabdomyolysis, and the combination should be avoided. Erythromycin in combination with Pitavastatin increases the risk of myopathy and rhabdomyolysis. If co-administration is required, the dose of pitavastatin should not exceed 1 mg/day. Rifampin in combination with Pitavastatin increases the risk of myopathy and rhabdomyolysis. If co-administration is required, the dose of pitavastatin should not exceed 2 mg/day. Fibrate, colchicine, niacin (dose > 1g/day) in combination with Pitavastatin increase the risk of myopathy and rhabdomyolysis. Therefore, the risks and benefits need to be weighed. The combination of Pitavastatin with Everolimus, sirolimus, tacrolimus should be avoided. Antiviral agents may affect plasma concentrations of Pitavastatin. Pitavastatin is used to treat primary hyperlipidemia or mixed dyslipidemia and atherosclerotic cardiovascular disease. To ensure effective treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, pharmacist for advice.
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